Výsledky vyhledávání - "Eberhardt Schleyer"

Proliferative activity of leukaemic blasts and cytosine arabinoside pharmacodynamics are associated with cytogenetically defined prognostic subgroups in acute myeloid leukaemia

Autor: Jan Braess, Michael Fiegl, Claudia Schoch, Wolfgang Kern, Torsten Haferlach, Wolfgang Hiddemann, Stefanie Voss, G. Jahns-Streubel, Eberhardt Schleyer, Detlef Haase

Publikováno v: British Journal of Haematology. 113:975-982

The biological mechanisms responsible for the association of specific karyotypes with prognosis in acute myeloid leukaemia (AML) remain largely unclear. A prospective study was performed to evaluate how far cytogenetically defined prognostic subgroup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c87d2c6c7d83f5a80968858b0ff3af52
https://doi.org/10.1046/j.1365-2141.2001.02866.x

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The pharmacodynamic basis for the increased antileukaemic efficacy of cytosine arabinoside-based treatment regimens in acute myeloid leukaemia with a high proliferative activity

Autor: S. Keye, G. Jahns-Streubel, Jan Braess, Eberhardt Schleyer, S. Voss, Claudia Schoch, Wolfgang Kern, Torsten Haferlach, Wolfgang Hiddemann

Publikováno v: British Journal of Haematology. 110:170-179

The current study was initiated to explore the mechanisms underlying the previously demonstrated association between the proliferative activity of leukaemic blasts and the response to cytosine arabinoside (AraC)-based therapy in de novo acute myeloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a12a83eb75fe16368d791d0ba807c80
https://doi.org/10.1046/j.1365-2141.2000.02151.x

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Successful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: no effect of ribonucleotide reductase inhibitors fludarabine and gemcitabine

Autor: Wolfgang Kern, Michael Unterhalt, Wolfgang Hiddemann, Susan Keye, Jan Braess, Eberhardt Schleyer, G. Jahns-Streubel, Christine Wegendt

Publikováno v: British Journal of Haematology. 109:388-395

High-dose cytosine arabinoside (AraC)-containing regimens have shown the highest antileukaemic efficacy of all currently used regimens in the treatment of acute myeloid leukaemia (AML). This study aimed at increasing the antileukaemic potential of hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1878459d4dd75031e35d4e576cea3a62
https://doi.org/10.1046/j.1365-2141.2000.02056.x

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Leukaemic blasts differ from normal bone marrow mononuclear cells and CD34+ haemopoietic stem cells in their metabolism of cytosine arabinoside

Autor: Wolfgang Kern, C. Wegendt, Michaela Feuring-Buske, Jan Braess, Joachim Riggert, Eberhardt Schleyer, Wolfgang Hiddemann

Publikováno v: British Journal of Haematology. 105:388-393

Different metabolites of cytosine arabinoside (AraC) contribute to its cytotoxicity including incorporation of AraCTP into DNA, the incorporation of AraUMP into RNA, inhibition of polymerase alpha and beta (AraCMP/CTP), an impairment of repair mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff1d2cd30463f2310b6ddc2da2bb253
https://doi.org/10.1111/j.1365-2141.1999.01338.x

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