Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Eberhard Jüngling"'
Autor:
Eberhard Jüngling, Andreas Lückhoff, Inka Heiner, Maike Warnstedt, Jörg Eisfeld, Natalia Radukina
Publikováno v:
Biochemical Journal. 398:225-232
TRPM2 (transient receptor potential melastatin 2) is a Ca2+-permeable cation channel gated by ADPR (ADP-ribose) from the cytosolic side. To test whether endogenous concentrations of intracellular ADPR are sufficient for TRPM2 gating in neutrophil gra
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 369:570-575
Cinnarizine is pharmaceutically used in conditions with vestibular vertigo such as Meniere's disease. It is thought to act on extra-vestibular targets. We hypothesized that cinnarizine, as a blocker of L-type Ca2+ channels, may directly target vestib
Autor:
Eberhard Jüngling, Rocco Hüneke, Rolf Rossaint, Jens Fassl, Andreas Lückhoff, Christian R. Halaszovich
Publikováno v:
Anesthesiology. 99:90-96
Background Anesthetics may cause cardiac side effects by their action on L-type Ca2+ channels. Direct effects on the channels have not yet been discriminated from an interference with the beta-adrenergic channel regulation. The authors therefore stud
Publikováno v:
Journal of Biological Chemistry. 277:23150-23156
LTRPC2 is a cation channel recently reported to be activated by adenosine diphosphate-ribose (ADP-ribose) and NAD. Since ADP-ribose can be formed from NAD and NAD is elevated during oxidative stress, we studied whole cell currents and increases in th
Publikováno v:
Journal of Biological Chemistry. 275:37423-37428
The lanthanide ions La(3+) and Gd(3+) block Ca(2+)-permeable cation channels and have been used as important tools to characterize channels of the transient receptor potential (TRP) family. However, widely different concentrations of La(3+) and Gd(3+
Autor:
Richard R. McKay, Eberhard Jüngling, Andreas Lückhoff, Jean-Philippe Lievremont, Gary S. Bird, Christof Zitt, Caroline L. Szymeczek-Seay, James W. Putney
Publikováno v:
Biochemical Journal. 351:735-746
Mammalian homologues of the Drosophila transient receptor potential (TRP) protein have been proposed to function as ion channels, and in some cases as store-operated or capacitative calcium entry channels. However, for each of the mammalian TRP prote
Autor:
Stephanie Grosskortenhaus, Dierk Vorwerk, Wolfgang Kromen, Rolf W. Günther, Helmut Kammerrmeier, Eberhard Jüngling, Armin Dick
Publikováno v:
CardioVascular and Interventional Radiology. 22:389-393
To quantify horseradish peroxidase (HRP) delivery into the arterial wall, as a model of local drug delivery, and to compare two different percutaneous delivery balloons.Perforated and hydrophilic hydrogel-coated balloon catheters were used to deliver
Autor:
M. Timmerman, C. Löken, Helmut Kammermeier, Eberhard Jüngling, Yvan Fischer, M. Mertens, I. Ionescu A.Aretz
Publikováno v:
Analytical Biochemistry. 239:41-46
In principle, luminometry allows very sensitive metabolite measurements as shown with standards in aqueous solutions (e.g., buffers). However, components of complex biological samples may largely interfere with luminometric reactions. We now describe
Autor:
H. Rose, C Carpéné, J Kamp, Yvan Fischer, Julia Thomas, Helmut Kammermeier, Eberhard Jüngling
Publikováno v:
Biochemical Journal. 311:575-583
This study deals with the effect of 5-hydroxytryptamine (5-HT; serotonin) on glucose transport in isolated rat cardiac myocytes. In these cells, 5-HT (10-300 microns), as well as tryptamine, 5-methoxytryptamine and dopamine, elicited a 3-5 fold incre
Autor:
Thomas Hennecke, H. Rose, Yvan Fischer, Martina Conventz, Helmut Kammermeier, Eberhard Jüngling
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1215:321-326
In studies on uptake of fatty acids (FA) into organs, the unbound (or free) fatty acid fraction is commonly calculated from the concentration bound to albumin and from published binding constants. However, there is some dispute on the methods used fo