Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Eberhard Hildt"'
Autor:
Marta Ferreira-Gomes, Yidan Chen, Pawel Durek, Hector Rincon-Arevalo, Frederik Heinrich, Laura Bauer, Franziska Szelinski, Gabriela Maria Guerra, Ana-Luisa Stefanski, Antonia Niedobitek, Annika Wiedemann, Marina Bondareva, Jacob Ritter, Katrin Lehmann, Sebastian Hardt, Christian Hipfl, Sascha Hein, Eberhard Hildt, Mareen Matz, Henrik E. Mei, Qingyu Cheng, Van Duc Dang, Mario Witkowski, Andreia C. Lino, Andrey Kruglov, Fritz Melchers, Carsten Perka, Eva V. Schrezenmeier, Andreas Hutloff, Andreas Radbruch, Thomas Dörner, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we de
Externí odkaz:
https://doaj.org/article/6afb3ecd327947ce81ffe2bed6522ae5
Autor:
Mirco Glitscher, Inga Mareike Spannaus, Fabiane Behr, Robin Oliver Murra, Kathrin Woytinek, Daniela Bender, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 4, Pp 589-605 (2024)
Background: A peculiar feature of the hepatitis E virus (HEV) is its reliance on the exosomal route for viral release. Genomic replication is mediated via the viral polyprotein pORF1, yet little is known about its subcellular localization. Methods: S
Externí odkaz:
https://doaj.org/article/d7e61af89377460ca741b230e6b20336
Autor:
Daniela Bender, Alexandra Koulouri, Xingjian Wen, Mirco Glitscher, Anja Schollmeier, Liliana Fernandes da Costa, Robin Oliver Murra, Gert Paul Carra, Vanessa Haberger, Gerrit J K Praefcke, Eberhard Hildt
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011976 (2024)
Viral infections trigger the expression of interferons (IFNs) and interferon stimulated genes (ISGs), which are crucial to modulate an antiviral response. The human guanylate binding protein 1 (GBP1) is an ISG and exhibits antiviral activity against
Externí odkaz:
https://doaj.org/article/12db4dd436b9413394872c091c0e886f
Autor:
Sascha Hein, Catarina Sabino, Nuka Ivalu Benz, Esra Görgülü, Thorsten Jürgen Maier, Doris Oberle, Eberhard Hildt
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Escape mutations in the spike protein of SARS-CoV-2 are a major reason for Omicron breakthrough infections. After basal vaccination only very low titers of Omicron neutralizing antibodies are present. However, booster vaccinations induce hig
Externí odkaz:
https://doaj.org/article/1f945376c32045e59dc30ba04e28f1fc
Autor:
Qingyan Wu, Mirco Glitscher, Susanne Tonnemacher, Anja Schollmeier, Jan Raupach, Tobias Zahn, Regina Eberle, Jacomine Krijnse-Locker, Michael Basic, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 237-259 (2023)
Background & Aims: Hepatitis B virus (HBV) was identified as an enveloped DNA virus with a diameter of 42 nm. Multivesicular bodies play a central role in HBV egress and exosome biogenesis. In light of this, it was studied whether intact virions wrap
Externí odkaz:
https://doaj.org/article/cdea57c472a2429dbc1ff347218eb19c
Publikováno v:
Viruses, Vol 15, Iss 8, p 1687 (2023)
Hepatitis D virus (HDV) is a defective RNA virus with a negative-strand RNA genome encompassing less than 1700 nucleotides. The HDV genome encodes only for one protein, the hepatitis delta antigen (HDAg), which exists in two forms acting as nucleopro
Externí odkaz:
https://doaj.org/article/c22cf97a554d41bfa6bb1233abd48a1a
Autor:
Daniela Bender, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 797-798 (2023)
Externí odkaz:
https://doaj.org/article/2184213963ef45cfabdb1c2a8ff49214
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4964 (2023)
The hepatitis B virus (HBV) counts as a major global health problem, as it presents a significant causative factor for liver-related morbidity and mortality. The development of hepatocellular carcinomas (HCC) as a characteristic of a persistent, chro
Externí odkaz:
https://doaj.org/article/e30a55009b9540b19a24031d685ff900
Autor:
Mirco Glitscher, David Heiler Martín, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Background and aims: The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular cho
Externí odkaz:
https://doaj.org/article/2c82aa411d1e43f98ee6cfc17d95c727
Autor:
Mirco Glitscher, Eberhard Hildt
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually all viruses. These seem to have developed manifold strategies to modulate the cholesterol metabolism to the side of lipid uptake and de novo synthesis. I
Externí odkaz:
https://doaj.org/article/95639d6952f842458c3da267067c6107