An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins

Autor: Lisbeth Nielsen Fink, Nina Buch-Månson, Knud J. Jensen, Narendra Kumar Mishra, Niels Vrang, Søren L. Pedersen, Karin Mannerstedt, Keld Fosgerau, Thomas Brimert, Philip J. Pedersen, Priska Le-Huu, Charlotte Madsen, Ebbe Engholm, Björn Borgström, Morten Lundh

Publikováno v: Chemistry – A European Journal. 27:3166-3176

A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1652c966395346e739b27aaa9084a02
https://doi.org/10.1002/chem.202004878

Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity

Autor: Damiano Lironi, Simon Boje Hansen, Maria Vinther, Feng Feng, Giles E. D. Oldroyd, Zoltan Bozsoki, Christian Kofoed, Sébastien Fort, John T. Sullivan, Manoj Kamble, Ebbe Engholm, Knud J. Jensen, Noor de Jong, Kira Gysel, Clive W. Ronson, Christina Krönauer, Mikkel B. Thygesen, Mickaël Blaise, Simona Radutoiu, Kasper R. Andersen, Jens Stougaard

Publikováno v: Science
Science, American Association for the Advancement of Science, 2020, 369 (6504), pp.663-670. ⟨10.1126/science.abb3377⟩
Bozsoki, Z, Gysel, K, Hansen, S B, Lironi, D, Krönauer, C, Feng, F, de Jong, N, Vinther, M, Kamble, M, Thygesen, M B, Engholm, E, Kofoed, C, Fort, S, Sullivan, J T, Ronson, C W, Jensen, K J, Blaise, M, Oldroyd, G, Stougaard, J, Andersen, K R & Radutoiu, S 2020, ' Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity ', Science (New York, N.Y.), vol. 369, no. 6504, pp. 663-670 . https://doi.org/10.1126/science.abb3377
Bozsoki, Z, Gysel, K, Hansen, S B, Lironi, D, Krönauer, C, Feng, F, De Jong, N, Vinther, M, Kamble, M, Thygesen, M B, Engholm, E, Kofoed, C, Fort, S, Sullivan, J T, Ronson, C W, Jensen, K J, Blaise, M, Oldroyd, G, Stougaard, J, Andersen, K R & Radutoiu, S 2020, ' Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity ', Science, vol. 369, no. 6504, pp. 663-670 . https://doi.org/10.1126/science.abb3377

Switching perception of friend and foe Lysine motif receptors in plants perceive glycans that signal the presence of pathogenic or symbiotic nitrogen-fixing microbes. Bozsoki et al. now define the portions of these receptors that create the discrimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d91d42ec086089ec66bf2e10b93c314
https://hal.archives-ouvertes.fr/hal-02917628/document

Characterization of avian influenza virus attachment patterns to human and pig tissues

Autor: Per, Eriksson, Cecilia, Lindskog, Ebbe, Engholm, Ola, Blixt, Jonas, Waldenström, Vincent, Munster, Åke, Lundkvist, Björn, Olsen, Elsa, Jourdain, Patrik, Ellström

Publikováno v: Eriksson, P, Lindskog, C, Engholm, E, Blixt, K O, Waldenstrom, J, Munster, V, Lundkvist, Å, Olsen, B, Jourdain, E & Ellström, P 2018, ' Characterization of avian influenza virus attachment patterns to human and pig tissues ', Scientific Reports, vol. 8, 12215 . https://doi.org/10.1038/s41598-018-29578-1
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-29578-1⟩
Scientific Reports 1 (8), . (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs). Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in their new hosts. Viral adaptions to mammalian hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e48828976381241cb506c579a227977
https://curis.ku.dk/ws/files/201601214/Characterization_of_avian_influenza_virus_attachment_patterns_to_human_and_pig_tissues.pdf

Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins

Autor: Thomas Lund Koch, Iris Bea L. Ramiro, Paula Flórez Salcedo, Ebbe Engholm, Knud Jørgen Jensen, Kevin Chase, Baldomero M. Olivera, Walden Emil Bjørn-Yoshimoto, Helena Safavi-Hemami

Publikováno v: Koch, T L, Ramiro, I B L, Flórez Salcedo, P, Engholm, E, Jensen, K J, Chase, K, Olivera, B M, Bjørn-Yoshimoto, W E, Safavi-hemami, H & True, J (ed.) 2022, ' Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins ', Molecular Biology and Evolution, vol. 39, no. 4, msac075 . https://doi.org/10.1093/molbev/msac075
Molecular Biology and Evolution

Somatostatin and its related peptides (SSRPs) form an important family of hormones with diverse physiological roles. The ubiquitous presence of SSRPs in vertebrates and several invertebrate deuterostomes suggests an ancient origin of the SSRP signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a257ea161f8724b00765ca5e5f89adef