Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties

Autor: Jacob Marthinsen Seefeldt, Casper Homilius, Jakob Hansen, Thomas Ravn Lassen, Nichlas Riise Jespersen, Rebekka Vibjerg Jensen, Ebbe Boedtkjer, Hans Erik Bøtker, Roni Nielsen

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)

Background The heart can metabolize the microbiota‐derived short‐chain fatty acid butyrate. Butyrate may have beneficial effects in heart failure, but the underlying mechanisms are unknown. We tested the hypothesis that butyrate elevates cardiac

Externí odkaz: https://doaj.org/article/09db12daf5764ce2b19de97f30c6eb03

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Autor: Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-27 (2023)

Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal

Externí odkaz: https://doaj.org/article/43eb9c61abb047289a64eb505c8ecf73

Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension

Autor: Roni Nielsen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Kristoffer Berg‐Hansen, Jacob Seefeldt, Casper Homilius, Ebbe Boedtkjer, Mads Jønsson Andersen, Henrik Wiggers, Niels Møller, Hans Erik Bøtker, Søren Mellemkjær

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 10 (2023)

Background Pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) are debilitating diseases with a high mortality. Despite emerging treatments, pulmonary vascular resistance frequently remains elevated. However

Externí odkaz: https://doaj.org/article/b887476f157846f885d0464c1fbb0322

PTPRG is an ischemia risk locus essential for HCO3–-dependent regulation of endothelial function and tissue perfusion

Autor: Kristoffer B Hansen, Christian Staehr, Palle D Rohde, Casper Homilius, Sukhan Kim, Mette Nyegaard, Vladimir V Matchkov, Ebbe Boedtkjer

Publikováno v: eLife, Vol 9 (2020)

Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort

Externí odkaz: https://doaj.org/article/553f7c2622b94fb89302d19517c3baa4

Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival

Autor: Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer

Publikováno v: Sloth, R A, Axelsen, T V, Espejo, M S, Toft, N J, Voss, N C S, Burton, M, Thomassen, M, Vahl, P & Boedtkjer, E 2022, ' Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival ', British Journal of Cancer, vol. 127, no. 7, pp. 1226-1238 . https://doi.org/10.1038/s41416-022-01911-6

Background: While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63847aec630ad694e2b288b99859f8e
https://doi.org/10.1038/s41416-022-01911-6