Výsledky vyhledávání - "Ebba U. Kurz"

Sodium salicylate is a novel catalytic inhibitor of human DNA topoisomerase II alpha

Autor: Ebba U Kurz, Jason T. Bau

Publikováno v: Biochemical Pharmacology. 81:345-354

We have previously reported that pretreatment of human lymphoblastoid cells with the hydroxyl radical scavenger, N-acetyl cysteine, attenuates doxorubicin-induced DNA damage signalling through the ATM protein kinase. We sought to extend these studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa081fccab0920b2402e472b8f39fe87
https://doi.org/10.1016/j.bcp.2010.10.009

Zobrazit plný text záznamu

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

Autor: Franz J. Zemp, Rajappa S. Kenchappa, Peter A. Forsyth, Brienne A. McKenzie, Aru Narendran, Ebba U Kurz, Xueqing Lun, Grant McFadden, Alexandra Pisklakova

Brain tumor-initiating cells (BTICs) are stem-like cells hypothesized to form a disease reservoir that mediates tumor recurrence in high-grade gliomas. Oncolytic virotherapy uses replication-competent viruses to target and kill malignant cells and ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f090a556dc4fed6132bd78ec7d64b0d
https://europepmc.org/articles/PMC4490869/

Zobrazit plný text záznamu

Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species

Autor: Pauline Douglas, Ebba U Kurz, Susan P. Lees-Miller

Publikováno v: Journal of Biological Chemistry. 279:53272-53281

The requirement for the serine/threonine protein kinase ATM in coordinating the cellular response to DNA damage induced by ionizing radiation has been studied extensively. Many of the anti-tumor chemotherapeutics in clinical use today cause DNA doubl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29df817ff7bef2c63d5f37db64cc0d8
https://doi.org/10.1074/jbc.m406879200

Zobrazit plný text záznamu

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

Autor: Susan P. Lees-Miller, Ebba U Kurz

Publikováno v: DNA Repair. 3:889-900

Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257f0a86e79ff926ddf6ce41d2b1525b
https://doi.org/10.1016/j.dnarep.2004.03.029

Zobrazit plný text záznamu

The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX

Autor: Aaron A. Goodarzi, Yuichiro Higashimoto, Ebba U Kurz, Ettore Appella, Carl W. Anderson, Susan P. Lees-Miller, Shin'ichi Saito, Martin F. Lavin, Ruiqiong Ye

Publikováno v: DNA Repair. 3:235-244

The ataxia-telangiectasia mutated (ATM) protein kinase is activated in response to ionizing radiation (IR) and activates downstream DNA-damage signaling pathways. Although the role of ATM in the cellular response to ionizing radiation has been well c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d333b7ef652707d5ac74eebf27dea2f
https://doi.org/10.1016/j.dnarep.2003.10.014

Zobrazit plný text záznamu

Structural determinants of the catalytic inhibition of human topoisomerase IIα by salicylate analogs and salicylate-based drugs

Autor: Ebba U Kurz, Jason T. Bau

Publikováno v: Biochemical pharmacology. 89(4)

We previously identified salicylate as a novel catalytic inhibitor of human DNA topoisomerase II (topo II; EC 5.99.1.3) that preferentially targets the alpha isoform by interfering with topo II-mediated DNA cleavage. Many pharmaceuticals and compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59617d655070cb8e0321e034d6fc4d13
https://pubmed.ncbi.nlm.nih.gov/24695359

Zobrazit plný text záznamu

Catalytic inhibition of human DNA topoisomerase IIα by hypericin, a naphthodianthrone from St. John’s wort (Hypericum perforatum)44Abbreviations: SJW, St. John’s wort; topo II, topoisomerase IIα; CAT, chloramphenicol acetyltransferase; and XRE, xenobiotic response element

Autor: Katherine A. Peebles, Ebba U. Kurz, B.J Schneider, Ronda K. Baker, David J. Kroll

Publikováno v: Biochemical Pharmacology. 62:1059-1070

St. John’s wort ( Hypericum perforatum ) is the most widely used herbal medicine for the treatment of depression. However, concerns have arisen about the potential of its interaction with other drugs due to the induction of cytochrome P450 isozymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62478f4e7b24121090eb618d2f539bea
https://doi.org/10.1016/s0006-2952(01)00759-6

Zobrazit plný text záznamu

Identification of DNA–Protein Interactions in the 5′ Flanking and 5′ Untranslated Regions of the Human Multidrug Resistance Protein (MRP1) Gene: Evaluation of a Putative Antioxidant Response Element/AP-1 Binding Site

Autor: Roger G. Deeley, Susan P.C. Cole, Ebba U. Kurz

Publikováno v: Biochemical and Biophysical Research Communications. 285:981-990

Overexpression of the multidrug resistance protein, MRP1, confers resistance to multiple natural product-type chemotherapeutics. MRP1 amplification is observed in some multidrug-resistant cell lines, while in others, increased transcription occurs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d149b657f32f8fe14a0cea5a7a4d1b5f
https://doi.org/10.1006/bbrc.2001.5262

Zobrazit plný text záznamu

Modulation of Human DNA Topoisomerase IIα Function by Interaction with 14-3-3ε

Autor: Michael Clark, Frank Gieseler, Ebba U. Kurz, David J. Kroll, Kelly B. Leader

Publikováno v: Journal of Biological Chemistry. 275:13948-13954

Human DNA topoisomerase IIalpha (topo II), a ubiquitous nuclear enzyme, is essential for normal and neoplastic cellular proliferation and survival. Several common anticancer drugs exert their cytotoxic effects through interaction with topo II. In exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63c3ddfcd14643716c0eedfde89fc062
https://doi.org/10.1074/jbc.275.18.13948

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání