Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Autor: Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, DM, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Team, 23Andme Research, Psychiatry, Hunt All-In, Choquet, H, Docherty, AR, Faul, JD, Foerster, JR, Fritsche, LG, Gabrielsen, ME, Gordon, SD, Haessler, J, Hottenga, J-J, Huang, H, Jang, S-K, Jansen, PR, Ling, Y, Mägi, R, Matoba, N, McMahon, G, Mulas, A, Orrù, V, Palviainen, T, Pandit, A, Reginsson, GW, Skogholt, AH, Smith, JA, Taylor, AE, Turman, C, Willemsen, G, Young, H, Young, KA, Zajac, GJM, Zhao, W, Zhou, W, Bjornsdottir, G, Boardman, JD, Boehnke, M, Boomsma, DI, Chen, C, Cucca, F, Davies, GE, Eaton, CB, Ehringer, MA, Esko, T, Fiorillo, E, Gillespie, NA, Gudbjartsson, DF, Haller, T, Harris, KM, Heath, AC, Hewitt, JK, Hickie, IB, Hokanson, JE, Hopfer, CJ, Hunter, DJ, Iacono, WG, Johnson, EO, Kamatani, Y, Kardia, SLR, Keller, MC, Kellis, M, Kooperberg, C, Kraft, P, Krauter, KS, Laakso, M, Lind, PA, Loukola, A, Lutz, SM, Madden, PAF, Martin, NG, McGue, M, McQueen, MB, Medland, SE, Metspalu, A, Mohlke, KL, Nielsen, JB, Okada, Y, Peters, U, Polderman, TJC, Posthuma, D, Reiner, AP, Rice, JP, Rimm, E, Rose, RJ, Runarsdottir, V, Stallings, MC, Stančáková, A, Stefansson, H, Thai, KK, Tindle, HA, Tyrfingsson, T, Wall, TL, Weir, DR, Weisner, C, Whitfield, JB, Winsvold, BS, Yin, J, Zuccolo, L, Bierut, LJ, Hveem, K, Lee, JJ, Munafò, MR, Saccone, NL, Willer, CJ, Cornelis, MC, David, SP, Hinds, DA, Jorgenson, E, Kaprio, J, Stitzel, JA, Stefansson, K, Thorgeirsson, TE, Abecasis, G, Liu, DJ, Vrieze, S

Publikováno v: Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, D M, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Hromatka, B S, Huber, K E, Kleinman, A, Litterman, N K, McIntyre, M H, Mountain, J L, Northover, C A M, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Wilson, C H, Pitts, S J, Mitchell, A, Skogholt, A H, Winsvold, B S, Sivertsen, B R, Stordal, E, Morken, G, Kallestad, H V, Heuch, I, Zwart, J-A, Fjukstad, K K, Pedersen, L M, Gabrielsen, M E, Jansen, P R, Posthuma, D, 23andMe Research team, Jorgenson, E, Stitzel, J A, Liu, D J & Vrieze, S 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
Nature Genetics
the 23 and Me Research Team 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
Nature Genetics, 51(2), 237-244. Nature Publishing Group
Liu, M, Hottenga, J J, Jansen, P R, Willemsen, G, Boomsma, D I, Davies, G E, Polderman, T J C, Posthuma, D, Vrieze, S, 23Andme Research Team & HUNT All-In Psychiatry 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
PMC
Nature genetics
Nature genetics, 51(2), 237-244. Nature Publishing Group

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6,7,8,9,10,11. In sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f01e166190b1f57e8157a42854d232
https://research.vumc.nl/en/publications/d6127763-905e-44ae-88b1-ab80a1e7e269

Trans-ethnic meta-analysis of white blood cell phenotypes

Autor: Keller, Margaux F, Reiner, Alexander P, Okada, Yukinori, van Rooij, Frank J. A, Johnson, Andrew D, Chen, Ming Huei, Smith, Albert V, Morris, Andrew P, Tanaka, Toshiko, Ferrucci, Luigi, Zonderman, Alan B, Lettre, Guillaume, Harris, Tamara, Garcia, Melissa, Bandinelli, Stefania, Qayyum, Rehan, Yanek, Lisa R, Becker, Diane M, Becker, Lewis C, Kooperberg, Charles, Keating, Brendan, Reis, Jared, Tang, Hua, Boerwinkle, Eric, Kamatani, Yoichiro, Matsuda, Koichi, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki, Liu, Simin, Dehghan, Abbas, Felix, Janine F, Hofman, Albert, Uitterlinden, André G, van Duijn, Cornelia M, Franco, Oscar H, Longo, Dan L, Singleton, Andrew B, Psaty, Bruce M, Evans, Michelle K, Cupples, L. Adrienne, Rotter, Jerome I, O'Donnell, Christopher J, Takahashi, Atsushi, Wilson, James G, Ganesh, Santhi K, Nalls, Mike A, Arepalli, S, Bandinelli, S, Biffi, A, Bis, Jc, Boerwinkle, E, Chakravarti, A, Chen, Mh, Chong, S, Coresh, J, Couper, Dj, Cupples, L, Dehghan, A, Do'Ring, A, Eiriksdottir, G, Felix, Jf, Ferrucci, L, Folsom, Ar, Fox, Cs, Frayling, Tm, Ganesh, Sk, Garcia, M, Garner, Sf, Gasparini, Paolo, Gieger, C, Glazer, Nl, Gouskova, Na, Greinacher, A, Gudnason, V, Harris, Tb, Hernandez, Dg, Hofman, A, Illig, T, Kamatani, Y, Kamatani, N, Kubo, M, Kuhnel, B, Lagou, V, Lettre, G, Levi, D, Lin, J, Liu, Y, Longo, Dl, Lumley, T, Mangino, M, Matsuda, K, Meisinger, C, Melzer, D, Menzel, S, Moore, M, Nakamura, Y, Nalls, Ma, Nauck, M, O'Donnell, Cj, Okada, Y, Oostra, Ba, Ouwehand, Wh, Patel, Kv, Pirastu, Nicola, Pistis, Giorgio, Prokisch, H, Prokopenko, I, Psaty, Bm, Reiner, Ap, Rendon, A, Sambrook, J, Singleton, Ab, Smith, Av, Soranzo, N, Spector, Td, Stephens, J, Stumvoll, M, Takahashi, A, Tanaka, T, Taylor, K, Teumer, A, Thein, Sl, To'Njes, A, Toniolo, D, Tsunoda, T, Uitterlinden, Ag, van Duijn CM, van Rooij FJ, Vo'Lker, U, Vo'Lzke, H, Wichmann, H., Wiggins, Kl, Wilson, Jg, Witteman, Jc, Wood, Ar, Yamamoto, K, Yang, Q, Zakai, Na, Austin, Ma, Becker, Dm, Britton, A, Chen, Z, Couper, D, Curb, J, Dean, E, Eaton, Cb, Evans, Mk, Fornage, M, Grant, Sf, Hernandez, D, Kamatini, N, Keating, Bj, Lacroix, A, Lange, La, Liu, S, Lohman, K, Mathias, R, Meng, Y, Mohler ER 3rd, Musani, S, Palmer, Cd, Papanicolaou, Gj, Snively, Bm, Tang, H, Taylor HA Jr, Thomson, C, Yanek, Lr, Yang, L, Ziv, E, Zonderman, Ab, Higasa, K, Hirota, T, Hosono, N, Kumasaka, N, Ohmiya, H, Tamari, M, Yamaguchi Kabata, Y, Yamamoto, K.

Publikováno v: Human Molecular Genetics, 23(25), 6944-6960. Oxford University Press

White blood cell (WBC) count is a common clinical measure used as a predictor of certain aspects of human health, including immunity and infection status. WBC count is also a complex trait that varies among individuals and ancestry groups. Difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce521bb0755e92c469a4e92e282e4155
https://pubmed.ncbi.nlm.nih.gov/25096241

Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative

Autor: Donneyong, MM, Hornung, CA, Taylor, KC, Baumgartner, RN, Myers, JA, Eaton, CB, Gorodeski, EZ, Klein, L, Martin, LW, Shikany, JM, Song, Y, Li, W, Manson, JAE

Publikováno v: Circulation. Heart failure, vol 8, iss 1
Donneyong, MM; Hornung, CA; Taylor, KC; Baumgartner, RN; Myers, JA; Eaton, CB; et al.(2015). Risk of heart failure among postmenopausal women a secondary analysis of the randomized trial of Vitamin D plus calcium of the women's health initiative. Circulation: Heart Failure, 8(1), 49-56. doi: 10.1161/CIRCHEARTFAILURE.114.001738. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2hg718mc

BackgroundVitamin D supplementation may be an inexpensive intervention to reduce heart failure (HF) incidence. However, there are insufficient data to support this hypothesis. This study evaluates whether vitamin D plus calcium (CaD) supplementation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::75fddf73e85c803c71a08f54906f8fca
https://escholarship.org/uc/item/2hg718mc

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Autor: Wu, Y, Waite, LL, Jackson, Anne U., Sheu, WHH, Buyske, Steven, Absher, D, Arnett, DK, Boerwinkle, E, Bonnycastle, LL, Carty, CL, Cheng, I, Cochran, B, Croteau-Chonka, DC, Dumitrescu, L, Eaton, CB, Franceschini, N, Guo, XQ, Henderson, BE, Hindorff, LA, Kim, E, Kinnunen, L, Komulainen, P, Lee, WJ, Le Marchand, L, Lin, Y, Lindstrom, J, Holmen, Oddgeir, Mitchell, SL, Narisu, N, Robinson, JG, Schumacher, F, Stancaakovaa, A, Sundvall, J, Sung, YJ, Swift, AJ, Wang, WC, Wilkens, L, Wilsgaard, Tom, Young, AM, Adair, LS, Ballantyne, CM, Buzkova, P, Chakravarti, A, Collins, FS, Duggan, D, Feranil, AB, Ho, LT, Hung, YJ, Hunt, SC, Hveem, Kristian, Juang, JMJ, Kesaniemi, AY, Kuusisto, J, Laakso, M, Lakka, TA, Lee, IT, Leppert, MF, Matise, TC, Moilanen, L, Njølstad, Inger, Peters, U, Quertermous, T, Rauramaa, R, Rotter, JI, Saramies, J, Tuomilehto, J, Uusitupa, M, Wang, TD, Boehnke, M, Haiman, CA, Chen, YDI, Kooperberg, C, Assimes, TL, Crawford, DC, Hsiung, CA, North, KE, Mohlke, Karen L.

Publikováno v: PLoS Genetics (2013), vol. 9(3): e1003379.

Externí odkaz: https://hdl.handle.net/10037/6053

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