Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Eastman Brian Walter"'
Autor:
Marakovits Joseph T, David R. Newell, Stephen E. Webber, Zdenek Hostomsky, Roger J. Griffin, Karen A. Maegley, Anne Ekker, Skalitzky Donald James, Bernard T. Golding, Robert Almassy, A. Hilary Calvert, Xiao-Hong Yu, Jianke Li, Eastman Brian Walter, Nicola J. Curtin
Publikováno v:
Journal of Medicinal Chemistry. 46:210-213
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines. In vitro
Autor:
Karen A. Maegley, Zdenek Hostomsky, Stephen E. Webber, Skalitzky Donald James, Bernard T. Golding, Alex William White, Xiao-Hong Yu, Jianke Li, Suzanne Kyle, Roger J. Griffin, Eastman Brian Walter, Nicola J. Curtin
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(10)
The synthesis and biological evaluation of a new series of amine-substituted 2-arylbenzimidazole-4-carboxamide inhibitors of the DNA-repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is reported. The introduction of an amine substituent at the 2-a
Autor:
Hiep T. Luu, Rose Ann Ferre, Fausto Maldonado, Peter S. Dragovich, Amy K. Patick, Skalitzky Donald James, Shella A. Fuhrman, Ye Hua, David A. Matthews, Shao Song Chu, Fora Chan, Edward L. Brown, Leora S. Zalman, Theodore O. Johnson, Eastman Brian Walter, Siegfried Reich, Michelle Yang, Stephen T. Worland, James W. Meador, Thomas F. Hendrickson
Publikováno v:
Journal of medicinal chemistry. 45(10)
Utilizing the tools of parallel synthesis and structure-based design, a new class of Michael acceptor-containing, irreversible inhibitors of human rhinovirus 3C protease (HRV 3CP) was discovered. These inhibitors are shown to inhibit HRV-14 3CP with