Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

Autor: Matico R; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Grauwen K; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Chauhan D; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Yu X; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Abdiaj I; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Adhikary S; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Adriaensen I; Janssen Research & Development, LLC, In Vivo Sciences (IVS), Turnhoutseweg 30, 2340, Beerse, Belgium., Aranzazu GM; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Alcázar J; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Bassi M; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Brisse E; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Cañellas S; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Chaudhuri S; Janssen Research & Development, LLC, Preclinical Sciences and Translational Safety (PSTS), Spring House, PA, 19044, USA., Delgado F; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Diéguez-Vázquez A; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Du Jardin M; Janssen Research & Development, LLC, Discovery Pharmaceutics, Turnhoutseweg 30, 2340, Beerse, Belgium., Eastham V; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Finley M; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Jacobs T; Janssen Research & Development, LLC, Preclinical Sciences and Translational Safety (PSTS), Turnhoutseweg 30, 2340, Beerse, Belgium., Keustermans K; Charles River Laboratories, Turnhoutseweg 30, 2340, Beerse, Belgium., Kuhn R; Janssen Interventional Oncology, Spring House, PA, 19044, USA., Llaveria J; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Leenaerts J; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Linares ML; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Martín ML; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Martín-Pérez R; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Martínez C; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Miller R; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Muñoz FM; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Muratore ME; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Nooyens A; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Perez-Benito L; Janssen Research & Development, LLC, Therapeutic Discovery, Turnhoutseweg 30, 2340, Beerse, Belgium., Perrier M; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Pietrak B; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Serré J; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Sharma S; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Somers M; Janssen Research & Development, LLC, Drug Metabolism and Phamacokinetcs (DMPK), Turnhoutseweg 30, 2340, Beerse, Belgium., Suarez J; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Tresadern G; Janssen Research & Development, LLC, Therapeutic Discovery, Turnhoutseweg 30, 2340, Beerse, Belgium., Trabanco AA; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Van den Bulck D; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Van Gool M; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Van Hauwermeiren F; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Varghese T; Janssen Research & Development, LLC, Discovery Technologies and Molecular Pharmacology (DTMP), Spring House, PA, 19044, USA., Vega JA; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), C. Río Jarama, 75, 45007, Toledo, Spain., Youssef SA; Janssen Research & Development, LLC, Preclinical Sciences and Translational Safety (PSTS), Turnhoutseweg 30, 2340, Beerse, Belgium., Edwards MJ; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium., Oehlrich D; Janssen Research & Development, LLC, Global Discovery Chemistry (GDC), Turnhoutseweg 30, 2340, Beerse, Belgium., Van Opdenbosch N; Janssen Interventional Oncology, Turnhoutseweg 30, 2340, Beerse, Belgium. nvanopde@its.jnj.com.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.

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Autor: ABRAHAM, KENNETH S.¹, WHITE, G. EDWARD¹

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