Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Easter G. Frazier"'
1
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
Autor: Xiao-Ming Guan, Douglas J. MacNeil, Myrna E. Trumbauer, Dawn E. Novi, Howard Y. Chen, Drew T. Weingarth, Yue Feng, Hong Yu, Airu Chen, Easter G. Frazier, Donald J. Marsh, Ramon E. Camacho, Shobhna Gopal-Truter, Lauren P. Shearman, Lex H.T. Van der Ploeg, Su Qian, Zhu Shen
Publikováno v: Molecular and Cellular Biology. 22:5027-5035
Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents. AgRP is believed to exert its effects through the blockade of signaling by alp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0152c7c06258272c0f0e426c1391cc9
https://doi.org/10.1128/mcb.22.14.5027-5035.2002
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3
[Untitled]
Autor: Donald J. Marsh, D. E. Macintyre, Xiao-Ming Guan, Michael J. Forrest, Easter G. Frazier, Airu S. Chen, Theodore N. Mellin, Ramon E. Camacho, Hong Yu, Jill K. Fisher, Van der Ploeg Lh, Joe Metzger, Alison M. Strack, Myrna E. Trumbauer, Howard Y. Chen, Shobhna Gopal-Truter
Publikováno v: Transgenic Research. 9:145-154
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::586a7faedae2998056546759a33e76a8
https://doi.org/10.1023/a:1008983615045
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4
Increases in Circulating Insulin-Like Growth Factor I Levels by the Oral Growth Hormone Secretagogue MK-0677 in the Beagle Are Dependent upon Pituitary Mediation1
Autor: Gert W. Niebauer, Tom Jacks, Easter G. Frazier, Roy G. Smith, P Cunningham, Klaus D. Schleim, D. Zhang, Howard Y. Chen, G. J. Hickey, William P. Feeney
Publikováno v: Endocrinology. 140:1552-1558
It has been well established that the spiroindoline sulfonamide MK-0677 stimulates GH secretion from the pituitary both in vitro and in vivo. MK-0677 has also been shown to increase serum insulin-like growth factor I (IGF-I) and cortisol levels in vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0917e17544ee5437db8a8a6e9936688
https://doi.org/10.1210/endo.140.4.6667
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5
Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles
Autor: Roy G. Smith, Easter G. Frazier, D Krupa, Ravi P. Nargund, Klaus D. Schleim, Tom Jacks, William P. Feeney, Arthur A. Patchett, Howard Y. Chen, G. J. Hickey
Publikováno v: Journal of Endocrinology. 152:183-192
We have reported that MK-0677 is a novel, orally active GH secretagogue that stimulates an immediate and longlasting increase in serum GH levels in dogs. Significant elevations in IGF-I levels were associated with the increased GH secretion. Cortisol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436fed3caa175d664b360942d14ed181
https://doi.org/10.1677/joe.0.1520183
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6
Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585
Autor: Easter G. Frazier, William P. Feeney, Terry D. Faidley, Susan Nicolich, Drisko J, L McGuire, P Cunningham, B Friscino, Howard Y. Chen, G. J. Hickey, C. Chang, P Laroque, Roy G. Smith, L L Anderson, D Krupa, Eric L. Rickes
Publikováno v: Journal of Endocrinology. 148:371-380
To investigate the effect of hypophyseal transection (HST) on GH secretagogue activity of the non-peptidyl GH secretagogue L-692,585 in the conscious pig, male castrated swine were randomly assigned to either a hypophyseal stalk transection group (HS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dee64d2e6c00f8693a1afca1e807425
https://doi.org/10.1677/joe.0.1480371
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7
Nematocidal activity of MK-801 analogs and related drugs
Autor: James M. Schaeffer, Easter G. Frazier, Dennis J. Underwood, Alan R. Bergstrom
Publikováno v: Biochemical Pharmacology. 48:411-418
A series of dibenzo[a,d]cycloalkenimines were evaluated for their affinity to the (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) binding site in Caenorhabditis elegans membranes and their nematocidal activity. The (+)-MK-80
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::679f9a1f054e3599dc41edf40667bf79
https://doi.org/10.1016/0006-2952(94)90114-7
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8
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
Autor: Zhixiong Ye, Scott D. Feighner, Andrew D. Howard, Myrna E. Trumbauer, Xiao-Ming Guan, Drew T. Weingarth, Easter G. Frazier, Ravi P. Nargund, Zhu Shen, Douglas J. MacNeil, Su Qian, Howard Y. Chen, J. R. Adams, L. H. T. Van Der Ploeg, Airu S. Chen, Roy G. Smith, Donald J. Marsh
Publikováno v: Endocrinology. 145(6)
Ghrelin, a stomach-derived orexigenic hormone, has stimulated great interest as a potential target for obesity control. Pharmacological evidence indicates that ghrelin's effects on food intake are mediated by neuropeptide Y (NPY) and agouti-related p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc31379a30b7511def83b1f3df7b7b9
https://pubmed.ncbi.nlm.nih.gov/15140838
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9
Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
Autor: Xiao-Ming Guan, Easter G. Frazier, Myrna E. Trumbauer, Hong Yu, L. H. T. Van Der Ploeg, Howard Y. Chen
Publikováno v: Neuroreport. 9(15)
Alterations of hypothalamic neuropeptide Y(NPY) and melanocortinergic functions in diet-induced obese (DIO) C57BL/6J mice were investigated by in situ hybridization. Compared with controls, the DIO mice displayed a profound induction (approximately 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c5d4d8561d0c8451bd274c625a483c
https://pubmed.ncbi.nlm.nih.gov/9855291
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10
A rapid, quantitative functional assay for measuring leptin
Autor: Manal A Morsy, Lex H.T Van der Ploeg, Michael R. Tota, Doris F. Cully, Charles Rosenblum, Easter G. Frazier, Jeffrey P Varnerin, Aurawan Vongs
Publikováno v: Molecular and cellular endocrinology. 143(1-2)
At present, leptin is quantitated using immuno-assays that measure leptin mass. Leptin biological activity is determined using protocols that measure feed consumption and weight reduction. These in vivo protocols are semi-quantitative and require lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0dd4470179b3023fd0586c4348a750
https://pubmed.ncbi.nlm.nih.gov/9806356
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