Safety, Tolerability, and Pharmacokinetics of Single Doses of Exidavnemab (BAN0805), an Anti-α-Synuclein Antibody, in Healthy Western, Caucasian, Japanese, and Han Chinese Adults.

Autor: Boström E; BioArctic AB, Stockholm, Sweden., Bachhav SS; AbbVie Inc., North Chicago, IL, USA., Xiong H; AbbVie Inc., North Chicago, IL, USA., Zadikoff C; AbbVie Inc., North Chicago, IL, USA., Li Q; AbbVie Inc., North Chicago, IL, USA., Cohen E; AbbVie Inc., North Chicago, IL, USA., Dreher I; AbbVie Inc., North Chicago, IL, USA., Torrång A; SDS Life Science AB, Stockholm, Sweden., Osswald G; BioArctic AB, Stockholm, Sweden., Moge M; BioArctic AB, Stockholm, Sweden., Appelkvist P; BioArctic AB, Stockholm, Sweden., Fälting J; BioArctic AB, Stockholm, Sweden., Odergren T; BioArctic AB, Stockholm, Sweden.

Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2024 Nov; Vol. 64 (11), pp. 1432-1442. Date of Electronic Publication: 2024 Aug 06.

Customizing carrier screening in the Chinese population: Insights from a 334-gene panel.

Autor: Liu S; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Huang S; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Zhang VW; AmCare Genomics Lab, Guangzhou, China., Cao L; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Liu H; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Wei X; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Luo Y; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Li Y; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Zhou L; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Li F; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.; Department of Reproductive Andrology/Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, China., Zhu Q; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China., Liu H; Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.

Publikováno v: Prenatal diagnosis [Prenat Diagn] 2024 Oct; Vol. 44 (11), pp. 1335-1343. Date of Electronic Publication: 2024 Jul 18.

Mutational signatures in 175 Chinese gastric cancer patients.

Autor: Liu F; Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, 200092, P. R. China.; Department of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, P. R. China., Hu N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Jiang K; Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing, 100044, P. R. China., Liu H; Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Wang M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Hu Y; Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Zhang T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Wu HH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Yang H; Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Weng H; Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, 200092, P. R. China.; Department of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, P. R. China., Dong P; Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, 200092, P. R. China.; Department of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, P. R. China., Giffen C; Information Management Services, Inc, Silver Spring, Bethesda, MD, 20904, USA., Zhu B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Lee MP; Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Abnet CC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Taylor PR; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA., Liu Y; Department of Oncology, Fudan University Pudong Medical Center, Shanghai, P. R. China. superliuyun@fudan.edu.cn., Liu Y; Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, 200092, P. R. China. liuyingbin@xinhuamed.com.cn.; Department of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, P. R. China. liuyingbin@xinhuamed.com.cn., Goldstein AM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA. goldstea@mail.nih.gov.

Publikováno v: BMC cancer [BMC Cancer] 2024 Sep 30; Vol. 24 (1), pp. 1208. Date of Electronic Publication: 2024 Sep 30.

Estimating carrier rates and prevalence of porphyria-associated gene variants in the Chinese population based on genetic databases.

Autor: Wang Y; Department of Basic Medicine, Hebei Medical University, 361 Zhongshan East Road, Chang'an District, Shijiazhuang, 050011, Hebei Province, China., Li N; Department of Public Health, Hebei Medical University, 361 Zhongshan East Road, Chang'an District, Shijiazhuang, 050011, Hebei Province, China., Zhang S; Hebei Key Laboratory of Rare Diseases, Shijiazhuang, 050000, Hebei, China. zsyinsjz@hebmu.edu.cn.; Porphyria Multi Disciplinary Team of the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. zsyinsjz@hebmu.edu.cn.

Publikováno v: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Sep 12; Vol. 19 (1), pp. 337. Date of Electronic Publication: 2024 Sep 12.

Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.

Autor: Ge YJ; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Chen SD; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Wu BS; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Zhang YR; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Wang J; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China., He XY; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Liu WS; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Chen YL; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Ou YN; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Shen XN; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Huang YY; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Gan YH; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Yang L; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Ma LZ; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Ma YH; Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China., Chen KL; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Chen SF; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Cui M; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Tan L; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China., Dong Q; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Zhao QH; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China., Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China., Jia JP; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China., Yu JT; Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Sep; Vol. 20 (9), pp. 6243-6256. Date of Electronic Publication: 2024 Jul 18.