Zobrazeno 1 - 10
of 8 431
pro vyhledávání: '"Early phase"'
Autor:
Victoria C Patterson, Philip G Tibbo, Sherry H Stewart, Joel Town, Candice E Crocker, Zenovia Ursuliak, Siranda Lee, Jason Morrison, Sabina Abidi, Kara Dempster, Maria Alexiadis, Neal Henderson, Alissa Pencer
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Several adversity-focused treatment trials have reported improvements to adversity sequelae (e.g., PTSD symptoms) and decreases in psychotic symptoms among individuals with psychotic disorders. Yet, no trials have examined the imp
Externí odkaz:
https://doaj.org/article/80e7c324064649e5830d10233d50737b
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 3, Pp 178-189 (2024)
Clinical trials, the empirical discipline of medical experimentation conducted on human subjects, have engendered a paradigm shift in medical research. The need for new clinical studies is paramount in the Middle East and North Africa (MENA) region,
Externí odkaz:
https://doaj.org/article/1d16e63ed8df4b75bbf6ea29a70a804b
Autor:
Christina Yap, Olalekan Lee Aiyegbusi, Emily Alger, Ethan Basch, Jill Bell, Vishal Bhatnagar, David Cella, Philip Collis, Amylou C. Dueck, Alexandra Gilbert, Ari Gnanasakthy, Alastair Greystoke, Aaron R. Hansen, Paul Kamudoni, Olga Kholmanskikh, Bellinda L. King-Kallimanis, Harlan Krumholz, Anna Minchom, Daniel O'Connor, Joan Petrie, Claire Piccinin, Khadija Rerhou Rantell, Saaeha Rauz, Ameeta Retzer, Steven Rizk, Lynne Wagner, Maxime Sasseville, Lesley K. Seymour, Harald A. Weber, Roger Wilson, Melanie Calvert, John Devin Peipert
Publikováno v:
EClinicalMedicine, Vol 76, Iss , Pp 102838- (2024)
Summary: Early phase clinical trials provide an initial evaluation of therapies’ risks and benefits to patients, including safety and tolerability, which typically relies on reporting outcomes by investigator and laboratory assessments. Use of pati
Externí odkaz:
https://doaj.org/article/67c77703c1de4dd99159ee45db094c8f
Autor:
Lena Feber, Stefan Leucht, Irene Bighelli, Josef Priller, Wulf-Peter Hansen, Nurul Husna Salahuddin, Mathias Harrer, Georgia Salanti
Publikováno v:
F1000Research, Vol 13 (2024)
Introduction Treating the early phase of schizophrenia is crucial for preventing further episodes and improving quality of life, functioning, and social inclusion. Pharmacotherapies are first-line treatments, but have limitations. There is consensus
Externí odkaz:
https://doaj.org/article/65b25af18b1542418e3677806bcf2b2e
Autor:
Jonathan Avery, Jennifer A.H. Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim, Lynda G. Balneaves
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influence patients’ decisio
Externí odkaz:
https://doaj.org/article/3e8a476a081b415184e9c3bbf3303e3f
Autor:
Nils Graber, Nina Canova, Denise Bryant‐Lukosius, Glenn Robert, Blanca Navarro‐Rodrigo, Lionel Trueb, George Coukos, Manuela Eicher, Tourane Corbière, Sara Colomer‐Lahiguera
Publikováno v:
Health Expectations, Vol 27, Iss 4, Pp n/a-n/a (2024)
Abstract Background Experience‐Based Co‐Design (EBCD) is a multi‐stage participatory action research process which was developed originally to increase patient involvement in service improvement initiatives. This viewpoint article serves as a r
Externí odkaz:
https://doaj.org/article/e5a2fa5990d74831bfb54e5f43fc3ac0
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
AimTo study Swedish pediatric oncologists’ practical and emotional experiences of referring, including and/or treating children in early-phase clinical trials.MethodsA nationwide study was conducted using a mixed-method approach. Structured intervi
Externí odkaz:
https://doaj.org/article/2f925433b0df4a9895d41e1946a97d77
Autor:
Lena Feber, Stefan Leucht, Irene Bighelli, Josef Priller, Wulf-Peter Hansen, Nurul Husna Salahuddin, Mathias Harrer, Georgia Salanti
Publikováno v:
F1000Research, Vol 13 (2024)
Introduction Treating the early phase of schizophrenia is crucial for preventing further episodes and improving quality of life, functioning, and social inclusion. Pharmacotherapies are first-line treatments, but have limitations. There is consensus
Externí odkaz:
https://doaj.org/article/a9253c39ee244b5fa17247effdf2b439
Autor:
Gabriel Revon-Rivière, Pauline Tibout, Jennifer Cabral, Aiman Siddiqi, Ashley Doka, Denise Mills, Karen Fung, Sandra Judd, Daniel A. Morgenstern, Sarah Cohen-Gogo
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100154- (2024)
In the context of hard-to-cure disease, pediatric oncologists may have to explore novel therapy options and explain their rationale, risks and constraints to patients and caregivers. The New Agents and Innovative Therapy (NAIT) program at Hospital fo
Externí odkaz:
https://doaj.org/article/1da122d14678415fbb7d3571cef5b7ce
Autor:
William W. T. Aye, Megan R. Stark, Kyla‐Louise Horne, Leslie Livingston, Sophie Grenfell, Daniel J. Myall, Toni L. Pitcher, Mustafa M. Almuqbel, Ross J. Keenan, Wassilios G. Meissner, John C. Dalrymple‐Alford, Tim J. Anderson, Campbell Le Heron, Tracy R. Melzer
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Recent work suggests that amyloid beta (Aβ) positron emission tomography (PET) tracer uptake shortly after injection (“early phase”) reflects brain metabolism and perfusion. We assessed this modality in a predominantly amyl
Externí odkaz:
https://doaj.org/article/f8cb6f52b3de4f4cb07cad6fb58b2990