Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Earlene M. Schmitt"'
Autor:
Kiran D. Patel, Wesley L. Cai, Thomas F. Westbrook, Francesc López-Giráldez, Earlene M. Schmitt, Anna Arnal-Estapé, Don X. Nguyen, Alexandra E. Albert, Siddhartha Tyagi, Minghui Zhao, Laura E. Stevens
Publikováno v:
Oncogene
Lineage selective transcription factors (TFs) are important regulators of tumorigenesis, but their biological functions are often context dependent with undefined epigenetic mechanisms of action. In this study, we uncover a conditional role for the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b441cf75afebff8688f9ad36c21e30
https://doi.org/10.1038/s41388-020-1246-z
https://doi.org/10.1038/s41388-020-1246-z
Autor:
Earlene M. Schmitt, Fabio Stossi, Matthew J. Ellis, Ivana Petrovic, James G. Christensen, Chad A. Shaw, Chad J. Creighton, Sufeng Mao, Hsiang Ching Chung, Jin-Peng Sun, Siddhartha Tyagi, Doug W. Chan, Amritha Nair, Julien Dubrulle, C. Kent Osborne, Rocio Dominguez-Vidana, Sarah J. Kurley, Charles Y. Lin, Rachel Schiff, Xiao Yu, Carolina Gutierrez, Mothaffar F. Rimawi, Kenneth L. Scott, Panagiotis Katsonis, Alexander Renwick, Tingting Sun, Lacey E. Dobrolecki, David M. Henke, Michael T. Lewis, Thomas F. Westbrook, Jeffrey W. Tyner, David J. Shields, Susan G. Hilsenbeck, Bing Zhang, Hui Li, Mayra Orellana, Olivier Lichtarge
Publikováno v:
Nature Medicine. 24:505-511
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer diagnosed in more than 200,000 women each year1 and is recalcitrant to targeted therapies(2,3). Although TNBCs harbor multiple hyperactive receptor tyrosine kinases (RTKs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bb0d9290c87517c4b828d60b229721
https://doi.org/10.1038/nm.4507
https://doi.org/10.1038/nm.4507
Autor:
Guang Hu, Natalya N. Pavlova, C. Kent Osborne, Don X. Nguyen, Chunshui Zhou, Ronald J. Bernardi, Chad J. Creighton, Stephen J. Elledge, Thomas F. Westbrook, Maria F. Botero, Chad A. Shaw, David A. Wheeler, Steven P. Gygi, Earlene M. Schmitt, Jian Huang, Jessica D. Kessler, Mohamed Bentires-Alj, Richard A. Gibbs, Rachel Schiff, Mitchell Rao, Kristen L. Meerbrey, Tingting Sun, Mamie Z. Li, Noah Dephoure, Donna M. Muzny, Nicola Aceto, Susan G. Hilsenbeck, I. Migliaccio
Publikováno v:
Cell. 144:703-718
SummaryAmong breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33866c6168bc93ce6717e565ae858bc0
https://doi.org/10.1016/j.cell.2011.02.003
https://doi.org/10.1016/j.cell.2011.02.003
Autor:
Tf. Westbrook, I. Migliaccio, CK Osborne, Maria F. Botero, Richard A. Gibbs, Earlene M. Schmitt, Stephen J. Elledge, SG Hilsenbeck, Ronald J. Bernardi, Jessica D. Kessler, Tingting Sun, Ca Shaw, D Wheeler, Don X. Nguyen, Rachel Schiff, Natalya N. Pavlova, Chad J. Creighton, Kristen L. Meerbrey
Publikováno v:
Cancer Research. 70:S6-10
Breast cancer is a collection of diseases with distinct clinical behaviors and underlying genetic causes. Triple-negative breast cancer (TNBC) is a common subtype of breast cancer that confers a particularly poor prognosis and is refractory to curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3d15147f489c3d3d6e9fd6c783e6c9
https://doi.org/10.1158/0008-5472.sabcs10-s6-10
https://doi.org/10.1158/0008-5472.sabcs10-s6-10
Autor:
Roderick T. Bronson, Earlene M. Schmitt, Karlyne M. Reilly, Tyler Jacks, M E McLaughlin, Shih Ts, Karen Cichowski, Santiago S
Publikováno v:
Science. 286:2172-2176
Neurofibromatosis type 1 (NF1) is a prevalent familial cancer syndrome resulting from germ line mutations in theNF1tumor suppressor gene. Hallmark features of the disease are the development of benign peripheral nerve sheath tumors (neurofibromas), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93aa87acc02305d652936fb0ea31b04f
https://doi.org/10.1126/science.286.5447.2172
https://doi.org/10.1126/science.286.5447.2172
Autor:
C. Ryan Miller, Thomas F. Westbrook, Julia L. Sun, Alexey Eroshkin, Anne F. Buckley, Hendrik Witt, Tracy Ann Read, Andrey Korshunov, Roger E. McLendon, Yanxin Pei, Michael D. Taylor, Phillip G. Febbo, Alok K. Tewari, Robert J. Wechsler-Reya, Colin E. Moore, Paul A. Northcott, Earlene M. Schmitt, Jun Wang, Stefan M. Pfister, Yoon Jae Cho
SummaryMedulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f501a5d8f677195a74bd67c351dac5f
https://europepmc.org/articles/PMC3285431/
https://europepmc.org/articles/PMC3285431/
Autor:
Daniel M. Albert, Earlene M. Schmitt, Roderick T. Bronson, Bart O. Williams, Lee Remington, Tyler Jacks, Robert A. Weinberg
Publikováno v:
Scopus-Elsevier
Homozygosity for a mutation in the Rb tumor suppressor gene causes mid-gestation embryonic lethality in the mouse. Using a two-step targeting protocol, we have constructed Rb homozygous mutant mouse embryonic stem cells and used them to create chimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f59d68896c6fce1b1a3242cc2459184
https://doi.org/10.1002/j.1460-2075.1994.tb06745.x
https://doi.org/10.1002/j.1460-2075.1994.tb06745.x
Autor:
Tingting Sun, Mamie Z. Li, Earlene M. Schmitt, Zachary C. Hartman, Peng Yu, Nicole L. Solimini, Bing Yu, Rachel Schiff, Stephen J. Elledge, Rocio Dominguez-Vidana, Tiffany Y.T. Hsu, Ido Golding, Ji Luo, Jessica D. Kessler, Anthony C. Liang, Chad A. Shaw, Michael R. Schlabach, Kristen L. Meerbrey, Kristopher T. Kahle, Thomas F. Westbrook, C. Kent Osborne, Susan G. Hilsenbeck, Ronald J. Bernardi, Samuel O. Skinner, Mitchell Rao, Chad J. Creighton, Qikai Xu
Publikováno v:
Science (New York, N.Y.). 335(6066)
Taking the Myc Despite nearly 30 years of research into the mechanisms by which Myc oncogene dysregulation contributes to tumorigenesis, there are still no effective therapies that inhibit Myc activity. Kessler et al. (p. 348 , published online 8 Dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c63d9b47513a219f0054ce3cdffbc
https://pubmed.ncbi.nlm.nih.gov/22267799
https://pubmed.ncbi.nlm.nih.gov/22267799
Autor:
Stephen J. Elledge, Xiaoyong Fu, Thomas F. Westbrook, Thomas A. Cooper, Anna E. Burrows, Earlene M. Schmitt, Justin E. Fang, Jason I. Herschkowitz, Alberto Ciccia, Ronald J. Bernardi, Guang Hu, Kevin Roarty, Jessica D. Kessler, Christopher S. Bland, Rachel Schiff, Jeffrey M. Rosen, Kristen L. Meerbrey, Tingting Sun, Mamie Z. Li
The discovery of RNAi has revolutionized loss-of-function genetic studies in mammalian systems. However, significant challenges still remain to fully exploit RNAi for mammalian genetics. For instance, genetic screens and in vivo studies could be broa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14485ec16efa63599e91cc37d4c08faa
https://europepmc.org/articles/PMC3048138/
https://europepmc.org/articles/PMC3048138/
Autor:
Robert A. Weinberg, Earlene M. Schmitt, Amin Fazeli, Margaret A. Goodell, Tyler Jacks, Roderick T. Bronson
Publikováno v:
Nature. 359:295-300
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predispos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72d2b6fa23256e9d4ae1601005d78f27
https://doi.org/10.1038/359295a0
https://doi.org/10.1038/359295a0