Výsledky vyhledávání - "Earl T. Wallick"

Mutational analysis of Glu-327 of Na+-K+-ATPase reveals stimulation of86Rb+uptake by external K+

Autor: Jerry B. Lingrel, Elizabeth A. Jewell-Motz, Lauren A. Millette, Carl L. Johnson, Katherine Tepperman, Earl T. Wallick

Publikováno v: American Journal of Physiology-Cell Physiology. 273:C2065-C2079

A competition assay of86Rb+uptake in HeLa cells transfected with ouabain-resistant Na+-K+-ATPase mutants revealed a stimulation of86Rb+uptake at low external concentrations (1 mM) of competitor (K+). Of the models that were tested, those that require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04c98d3d7c2cb99075b1762074cda31
https://doi.org/10.1152/ajpcell.1997.273.6.c2065

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Different distribution of the α2 Na+, K+-ATPase isoform between rat atria and ventricles

Autor: Earl T. Wallick, Shin-Woong Lee, Jeung-Soo Lee

Publikováno v: Archives of Pharmacal Research. 19:381-385

Rat ventricles respond with a biphasic positive inotropic effect to ouabain, low-dose and high-dose effects but rat atria with only a monophasic high dose effect. In an effect to understand the difference in response to ouabain of two tissues between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43577e14a79732446f9ae7b794974df4
https://doi.org/10.1007/bf02976382

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Altered cardiac Na+,K+-ATPase activity in prehypertensive spontaneously hypertensive rat

Autor: Earl T. Wallick, Jeung Soo Lee, Shin Woong Lee

Publikováno v: Archives of Pharmacal Research. 16:305-311

Na+,K+-ATPase activity, Na+-dependent phosphorylation, and [3H]ouabain binding in sarcolemma prepared from 4 week old spontaneously hypertensive rat(SHR) ventricles were compared to the same parameters in sarcolemma from age matched normotensive Wist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af3bc46acfe536d39fcae495e6beda3a
https://doi.org/10.1007/bf02977521

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Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions

Autor: Earl T. Wallick, Jerry B. Lingrel, Patrick J. Schultheis

Publikováno v: Journal of Biological Chemistry. 268:22686-22694

Cardiac glycosides inhibit the Na,K-ATPase by binding to the catalytic alpha subunit of the enzyme. Site-directed mutagenesis of the H1-H2 domain has demonstrated the importance of this region in determining cardiac glycoside affinity. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a8bc4c51bf66752745ce4e438e99e48
https://doi.org/10.1016/s0021-9258(18)41582-7

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Amino acid residues of the Na,K-ATPase involved in ouabain sensitivity do not bind the sugar moiety of cardiac glycosides

Autor: Earl T. Wallick, William J. O'Brien, Jerry B. Lingrel

Publikováno v: Journal of Biological Chemistry. 268:7707-7712

The identification of amino acid substitutions in the alpha subunit of the Na,K-ATPase that alter cardiac glycoside sensitivity provides a unique opportunity to examine the role these residues play in binding to the structural domains of these drugs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad26c40733c360b8213a5060466ae537
https://doi.org/10.1016/s0021-9258(18)53014-3

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Purification of the Alpha and Beta Subunits of (Na,K)-ATPase by Continuous Elution Electrophoresis

Autor: Terence L. Kirley, M. J. Treuheit, A. Ataei, Earl T. Wallick

Publikováno v: Preparative Biochemistry. 23:375-387

Covalent structural information on membrane proteins is not easily acquired since it is difficult to obtain pure membrane proteins in sufficient quantities. We have therefore examined the Bio-Rad 491 prep cell continuous elution electrophoresis appar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7ddb2ad3b67f714895e788c63223b4
https://doi.org/10.1080/10826069308544563

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Purification of the glycosylated beta subunit of (Na,K)-ATPase by lectin affinity chromatography

Autor: Earl T. Wallick, A. Ataei, Terence L. Kirley, M. J. Treuheit

Publikováno v: Chromatographia. 33:521-524

Wheat germ agglutinin (WGA) affinity chromatography was examined as a method for the purification of the glycosylated beta subunit from SDS solubilized (Na,K)-ATPase. This lectin, WGA, bound quantitatively all of the beta subunit from SDS solubilized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f941b44c7a11d96cea2b32f4f0be8609
https://doi.org/10.1007/bf02262242

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Isolation and Purification of the Extracellular and Intracellular Portions of the Beta Subunit of (Na+, K+)-Atpase

Autor: Earl T. Wallick, Ali Ataei

Publikováno v: Preparative Biochemistry. 22:123-133

The beta subunit of lamb kidney (Na+,K+)-ATPase was isolated by size exclusion high performance liquid chromatography. Treatment of the beta subunit with formic acid yielded two peptide fragments which were purified via reversed phase high performanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed519d769654c3caa3144669ca30bcc
https://doi.org/10.1080/10826069208021363

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Sodium Pump Function

Autor: Lauren A. Millette, Earl T. Wallick, David M. Balshaw

Publisher Summary This chapter discusses the functions of the sodium pump in relation to the development of biological membranes. As biological complexity increased, more elaborate transport activities evolved to improve the control of the organism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2154c8f6bfa944885cd57320422733a6
https://doi.org/10.1016/b978-0-08-057455-4.50030-x

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