Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Earl R. Stadtman"'
Publikováno v:
Proceedings of the National Academy of Sciences. 104:66-71
To investigate the effect of RNA oxidation on normal cellular functions, we studied the translation of nonoxidized and oxidized luciferase mRNA in both rabbit reticulocyte lysate and human HEK293 cells. When HEK293 cells transfected with nonoxidized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db127a4f9555afba0a18d2aacfa4518e
https://doi.org/10.1073/pnas.0609737104
https://doi.org/10.1073/pnas.0609737104
Autor:
Earl R. Stadtman
Publikováno v:
EcoSal Plus. 1(1)
Detailed studies of the glutamine synthetase (GS) in Escherichia coli and other bacteria have shown that the activity of this enzyme is regulated by at least five different mechanisms: (i) cumulative feedback inhibition by multiple end products of gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca618ba4d1e857ca164b0f4998bef11
https://pubmed.ncbi.nlm.nih.gov/26443348
https://pubmed.ncbi.nlm.nih.gov/26443348
Autor:
Moon B. Yim, Koji Uchida, Sue Goo Rhee, Earl R. Stadtman, Kanghwa Kim, Ho Zoon Chae, Luis Eduardo Soares Netto
Publikováno v:
Annals of the New York Academy of Sciences. 738:86-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be702a529b0404c9c960179044bed8e
https://doi.org/10.1111/j.1749-6632.1994.tb21793.x
https://doi.org/10.1111/j.1749-6632.1994.tb21793.x
Publikováno v:
Proceedings of the National Academy of Sciences. 103:1727-1731
Cell death plays a pivotal role in the body to maintain homeostasis during aging. Studies have shown that damaged cells, which must be removed from the body, accumulate during aging. Decay of the capacity and/or control of cell death during aging is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bb24d0736007847295cd8270a8bdd7
https://doi.org/10.1073/pnas.0510346103
https://doi.org/10.1073/pnas.0510346103
Autor:
Earl R. Stadtman
Publikováno v:
Annals of the New York Academy of Sciences. 928:22-38
Although different theories have been proposed to explain the aging process, it is generally agreed that there is a correlation between aging and the accumulation of oxidatively damaged proteins, lipids, and nucleic acids. Oxidatively modified protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a9f8ac4519465a88aa3462058fc709
https://doi.org/10.1111/j.1749-6632.2001.tb05632.x
https://doi.org/10.1111/j.1749-6632.2001.tb05632.x
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2322-2327
The activation of caspase-12 is involved in endoplasmic reticulum-mediated apoptosis. To investigate how caspase-12 is transcriptionally and translationally regulated, we isolated and sequenced the 5′-flanking region of mouse caspase-12 gene by a P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1a4529eeb75c4bd5f30fe4aa86b355
https://doi.org/10.1073/pnas.0409874102
https://doi.org/10.1073/pnas.0409874102
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1703:135-140
It is well established that many amino acid residues of proteins are susceptible to oxidation by various forms of reactive oxygen species (ROS), and that oxidatively modified proteins accumulate during aging, oxidative stress, and in a number of age-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d374cfa9baa3829bb174c37195a6f73
https://doi.org/10.1016/j.bbapap.2004.08.010
https://doi.org/10.1016/j.bbapap.2004.08.010
Autor:
Earl R. Stadtman
Publikováno v:
Archives of Biochemistry and Biophysics. 423:2-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435866f748e78bf2fbc822cdd2e8f560
https://doi.org/10.1016/j.abb.2003.10.001
https://doi.org/10.1016/j.abb.2003.10.001
Publikováno v:
Neuropathology and Applied Neurobiology. 30:161-168
The biological function of cellular prion protein PrPc has not been established, despite in vitro studies suggesting antioxidant activity or link to signal transduction pathways. In this study, mice were exposed to hyperoxia to establish whether oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cf6d66faf2e16e3dcfcd0f88a294ca
https://doi.org/10.1111/j.1365-2990.2003.00523.x
https://doi.org/10.1111/j.1365-2990.2003.00523.x
Autor:
Earl R. Stadtman, Rodney L. Levine
Publikováno v:
Amino Acids. 25:207-218
We summarize here results of studies designed to elucidate basic mechanisms of reactive oxygen (ROS)-mediated oxidation of proteins and free amino acids. These studies have shown that oxidation of proteins can lead to hydroxylation of aromatic groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f749b91b141b3291e39e8a27ead333
https://doi.org/10.1007/s00726-003-0011-2
https://doi.org/10.1007/s00726-003-0011-2