Výsledky vyhledávání - "Earl R. Shelton"

Comparison of Recombinant Human PDE4 Isoforms

Autor: Natalie Saldou, Ling Xia, Anita Huber, Earl R. Shelton, Robert Stephen Wilhelm, Kurt Jarnagin, Cheng Su, Ondine Harris Callan, Robert Alvarez, Rena Obernolte, Bin Li, Preston A. Baecker

Publikováno v: Cellular Signalling. 10:427-440

Four cyclic-nucleotide phosphodiesterase (PDE) genes belonging to the PDE4 family (PDE4A, 4B, 4C and 4D) have been identified. All four isogenes, including several deletions and alterations of the amino, carboxyl and central catalytic domains, were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54ad9fe07b33f0b68d86157d29bfeb79
https://doi.org/10.1016/s0898-6568(97)00169-1

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Characterization of the Rolipram-Sensitive, Cyclic AMP-Specific Phosphodiesterases: Identification and Differential Expression of Immunologically Distinct Forms in the Rat Brain

Autor: M. Conti, Martin Hess, Saveria Iona, Fabio Naro, Margherita Cuomo, Earl R. Shelton, Tamara Bushnik, Claudio Sette

Publikováno v: Scopus-Elsevier

To determine the properties of the cAMP-specific, rolipram-sensitive phosphodiesterases (cAMP-PDEs) that are expressed in different organs, monoclonal and polyclonal antibodies were raised against different epitopes present in the cAMP-PDE sequences.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3b685c0e5c722752bb2f1f5f805398
https://doi.org/10.1124/mol.53.1.23

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Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain

Autor: James G. Beeson, Hardy W. Chan, Earl R. Shelton, Fred H. Gage

Publikováno v: The Journal of Comparative Neurology. 342:69-77

Alzheimer's disease (AD) is characterized by the extensive deposition of the 42-amino-acid beta-amyloid or A4 protein in neuritic plaques and neurofibrillary tangles within the brain. This protein is liberated from the much larger amyloid protein pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e6efe23aeb45788790cf2a66ee7ed1
https://doi.org/10.1002/cne.903420108

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Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease

Autor: Barry D. Greenberg, Mitsuru Kawai, Hardy W. Chan, Sandra L. Siedlak, Earl R. Shelton, Patrick Cras, Manuel E. Velasco, Rajesh N. Kalaria, George Perry

Publikováno v: Brain Research. 623:142-146

In cerebral amyloid angiopathy, the amyloid-beta (A beta) deposits lie primarily in the tunica media suggesting that smooth muscle cells play an important role in A beta deposition. To define this role, we conducted an immunocytochemical study of bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b34e9f29b5cd93613a17822d0ce1c58
https://doi.org/10.1016/0006-8993(93)90021-e

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The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

Autor: Chinh Bach, Mary Mulkins, Patti Zuppan, Rena Obernolte, Sunil Bhakta, Earl R. Shelton, Robert A Alvarez, Kurt Jarnagin

Publikováno v: Gene. 129:239-247

Five protein families are needed to encompass the diversity of cyclic-AMP (cAMP) phosphodiesterases (PDE). Family IV PDEs (PDE IV) specifically hydrolyze cAMP with a low Km, and are selectively inhibited by rolipram (Rp) and related drugs. Cloned cDN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4be861af94237c5fe72eac7f2b8603
https://doi.org/10.1016/0378-1119(93)90274-7

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Accumulation of the β amyloid precursor protein at sites of ischemic injury in rat brain

Autor: W. D. Lust, E. A. Palatinsky, Rajesh N. Kalaria, Hardy W. Chan, George Perry, Earl R. Shelton, D. H. Pennington, S. U. Bhatti

Publikováno v: NeuroReport. 4:211-214

We used various antibodies to the beta amyloid precursor protein (APP) of Alzheimer's disease to study changes in the cellular distribution of APP in experimental ischemic brain injury. In contrast to sham operated controls, rats with repeated revers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2feb1cdaef37e6e62affb9571406d04
https://doi.org/10.1097/00001756-199302000-00025

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Amyloid Precursor Protein (APP) in the Striatum in Alzheimerʼs Disease: An Immunohistochemical Study

Autor: Elizabeth R. Unger, Marla Gearing, Hardy W. Chan, Reginald W. Wilson, Earl R. Shelton, Suzanne S. Mirra, Colin L. Masters, Konrad Beyreuther

Publikováno v: Journal of Neuropathology and Experimental Neurology. 52:22-30

Increasing recognition of diffuse plaques has raised questions about the differences between diffuse and neuritic plaques, particularly in regard to the role of amyloid precursor protein (APP) processing in their formation. To address this issue, cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5082c9fe32348aa15b548e01e71a51f1
https://doi.org/10.1097/00005072-199301000-00004

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Purification and physical characterization of cloned human cAMP phosphodiesterases PDE-4D and -4C

Autor: Zhengyu Yuan, Natalie Saldou, Rena Obernolte, Preston A. Baecker, James Ratzliff, Bin Li, Earl R. Shelton, Eric Osen, Kurt Jarnagin

Publikováno v: Cell biochemistry and biophysics. 28(2-3)

Individual isozymes of family four cyclic-nucleotide phosphodiesterases (PDE-4s) were characterized and compared in order to advance our understanding of how PDE-4s regulate cAMP levels in cells. Full-length and shorter clones containing various func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcd67b84a8f4ceca488b47ae0d6ab38
https://pubmed.ncbi.nlm.nih.gov/9515166

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Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

Autor: Kurt Jarnagin, Rena Obernolte, James Ratzliff, Patti Zuppan, Earl R. Shelton, Donald V. Daniels, Preston A. Baecker

Publikováno v: Biochimica et biophysica acta. 1353(3)

Four closely related cyclic-nucleotide specific phosphodiesterase (PDE4) genes have been identified in both humans and rats: PDE4A, 4B, 4C and 4D. We have now cloned cDNAs for multiple splice variants of human PDE4C. Two splice variants, PDE4C-791 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da7a6373e7ce0afd06887705a6f196
https://pubmed.ncbi.nlm.nih.gov/9349724

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