Mapping the Endogenous Ketogenic System Across Ages, Sex and Diets

Autor: Eap, Brenda, Nomura, Mitsunori, Panda, Oishika, Garcia, Thelma, Newman, John

Publikováno v: Innovation in Aging

Understanding how our cells maintain energy homeostasis has long been a focus of aging biology. A decline in energy metabolism is central to many age-related diseases such as Alzheimer’s disease, heart failure, frailty, and delirium. Intervening on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10c38fd7ba8f888d0deb33b55d44888
https://doi.org/10.1093/geroni/igab046.3506

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.

Autor: Madhavan SS; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Roa Diaz S; Buck Institute for Research on Aging, Novato, CA 94945, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Peralta S; Buck Institute for Research on Aging, Novato, CA 94945, USA., Nomura M; Buck Institute for Research on Aging, Novato, CA 94945, USA., King CD; Buck Institute for Research on Aging, Novato, CA 94945, USA., Ceyhan KE; Buck Institute for Research on Aging, Novato, CA 94945, USA., Lin A; Buck Institute for Research on Aging, Novato, CA 94945, USA., Bhaumik D; Buck Institute for Research on Aging, Novato, CA 94945, USA., Foulger AC; Buck Institute for Research on Aging, Novato, CA 94945, USA., Shah S; Buck Institute for Research on Aging, Novato, CA 94945, USA., Blade T; Buck Institute for Research on Aging, Novato, CA 94945, USA., Gray W; Buck Institute for Research on Aging, Novato, CA 94945, USA., Chamoli M; Buck Institute for Research on Aging, Novato, CA 94945, USA., Eap B; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Panda O; Buck Institute for Research on Aging, Novato, CA 94945, USA., Diaz D; Buck Institute for Research on Aging, Novato, CA 94945, USA., Garcia TY; Buck Institute for Research on Aging, Novato, CA 94945, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA., Stubbs BJ; Buck Institute for Research on Aging, Novato, CA 94945, USA., Ulrich SM; Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA., Lithgow GJ; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Schilling B; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Chaudhuri AR; Buck Institute for Research on Aging, Novato, CA 94945, USA., Newman JC; Buck Institute for Research on Aging, Novato, CA 94945, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94118, USA. Electronic address: jnewman@buckinstitute.org.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.