Výsledky vyhledávání - "Ean G. Phillips"

Akademický článek

Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice

Autor: Kirk P. Conrad, Ean G. Phillips, Jessica Jiron, Julie Bailes, Biswadeep Dhar, YanPeng Diao, Jose Ignacio Aguirre, Joshua F. Yarrow

Publikováno v: Physiological Reports, Vol 7, Iss 11, Pp n/a-n/a (2019)

Abstract Bone fractures are associated with considerable morbidity and increased mortality. A major limitation to healing is lack of bone blood flow, which is impaired by physical disruption of intraskeletal and/or periosteal vasculature by the fract

Externí odkaz: https://doaj.org/article/1aa3b06f0b1143b5ac11a2828307059e

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Akademický článek

Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury.

Autor: Ean G Phillips, Luke A Beggs, Fan Ye, Christine F Conover, Darren T Beck, Dana M Otzel, Payal Ghosh, Anna C F Bassit, Stephen E Borst, Joshua F Yarrow

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194440 (2018)

Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, t

Externí odkaz: https://doaj.org/article/1b9b5703cd45433a8670c7492f56764a

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Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats

Autor: Philip J. Scarpace, J. Ignacio Aguirre, Nihal Tümer, Cong Chen, Dana M. Otzel, Hale Z. Toklu, Yasemin Sakarya, Thomas J. Wronski, Joshua F. Yarrow, Ean G. Phillips, Alex Balaez

Publikováno v: Bone. 85:99-106

Dietary-induced obesity (DIO) resulting from high-fat (HF) or high-sugar diets produces a host of deleterious metabolic consequences including adverse bone development. We compared the effects of feeding standard rodent chow (Control), a 30% moderate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365798b6425a259a9cf614bf3be9b345
https://doi.org/10.1016/j.bone.2016.02.004

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Longitudinal Examination of Bone Loss in Male Rats After Moderate–Severe Contusion Spinal Cord Injury

Publikováno v: Calcif Tissue Int

To elucidate mechanisms of bone loss after spinal cord injury (SCI), we evaluated the time-course of cancellous and cortical bone microarchitectural deterioration via microcomputed tomography, measured histomorphometric and circulating bone turnover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f93d77d8d0cc0d3b2c526dee1ded38
https://europepmc.org/articles/PMC8349506/

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Zoledronate treatment duration is linked to bisphosphonate-related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis

Autor: E.J. Castillo, J.M. Jiron, Catherine Van Poznak, Jorge L Mendieta Calle, Ronnie Israel, Jonathan G. Messer, Joshua F. Yarrow, Ean G. Phillips, Lakshmyya Kesavalu, J. Ignacio Aguirre, Donald B. Kimmel

Publikováno v: Oral Diseases

Objectives To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07c4c3d38fee064757484cb270465ef
https://pubmed.ncbi.nlm.nih.gov/30712276

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Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury

Autor: Anna C F Bassit, Fan Ye, Dana M. Otzel, Luke A. Beggs, Payal Ghosh, Stephen E. Borst, Darren T. Beck, Joshua F. Yarrow, Ean G. Phillips, Christine F. Conover

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194440 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb720ddbe8c121c6b967b0625ef63b0
http://europepmc.org/articles/PMC5868788

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Sclerostin Inhibition Prevents Spinal Cord Injury-Induced Cancellous Bone Loss

Autor: Darren T. Beck, Alyssa A. Williams, Joshua F. Yarrow, Ean G. Phillips, Payal Ghosh, Julie R Miller, JIgnacio Aguirre, Stephen E. Borst, Christine F. Conover, Thomas J. Wronski, Alexander Balaez, Nigel Zheng, Fan Ye, Prodip Bose, Luke A. Beggs

Publikováno v: Journal of Bone and Mineral Research. 30:681-689

Spinal cord injury (SCI) results in rapid and extensive sublesional bone loss. Sclerostin, an osteocyte-derived glycoprotein that negatively regulates intraskeletal Wnt signaling, is elevated after SCI and may represent a mechanism underlying this ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e0c157e6555798495d464bff2a7821b
https://doi.org/10.1002/jbmr.2396

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Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model

Autor: Hannah Prock, Cong Chen, J.M. Jiron, Jonathan Alerte, Stephen E. Borst, Taylor E. Bassett, Joshua F. Yarrow, Ean G. Phillips, Andrea Vasconez, Fan Ye, Tyler Teurlings, Micah Flores, J. Ignacio Aguirre, Christine F. Conover

Publikováno v: J Neurotrauma

We have reported that testosterone-enanthate (TE) prevents the musculoskeletal decline occurring acutely after spinal cord injury (SCI), but results in a near doubling of prostate mass. Our purpose was to test the hypothesis that administration of TE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabd9c2432793dda8e6ddf937965891e
https://europepmc.org/articles/PMC8387979/

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