Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eamonn Rooney"'
Autor:
Nicolas Muzet, Matthew Holderfield, Kanika Sharma, Eamonn Rooney, Bertrand Vivet, Renaud Morales, Christophe Marcireau, Ming Yi, Laurent Debussche, Frederic Lacroix, Walter Englaro, Julia Frappier, Dwight V. Nissley, Emilie Schell, Lick Pui Lai, Frank McCormick, Viviane Brel, Nicolas Basse, Nadia Le-Henanf
Publikováno v:
SLAS Discov
SLAS discovery : advancing life sciences R & D, vol 26, iss 7
SLAS discovery : advancing life sciences R & D, vol 26, iss 7
Oncogenic forms of KRAS proteins are known to be drivers of pancreatic, colorectal, and lung cancers. The goal of this study is to identify chemical leads that inhibit oncogenic KRAS signaling. We first developed an isogenic panel of mouse embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf6c04fdb321a2d5f4df9c3ee736f2e
https://doi.org/10.1177/24725552211008853
https://doi.org/10.1177/24725552211008853
Autor:
Nicolas Muzet, Matthew Holderfield, Julia Frappier, Renaud Morales, Christophe Marcireau, Eamonn Rooney, Frank McCormick, Dwight V. Nissley, Nadia Le-Henanf, Laurent Debussche, Frederic Lacroix, Walter Englaro, Kanika Sharma, Vivet Bertrand, Viviane Brel, Emilie Schell, Lick Pui Lai
Publikováno v:
Cancer Research. 80:6425-6425
The normal RAS signaling pathway provides a primary switch whereby cell proliferation is controlled through activation of RAS proteins and downstream signaling. Oncogenic mutants of RAS genes often drive hyper-activation of cell proliferation and sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2b11d389b807566430fb6d5c2409a2
https://doi.org/10.1158/1538-7445.am2020-6425
https://doi.org/10.1158/1538-7445.am2020-6425
Autor:
Yi Li, Gejing Deng, Vinod Patel, Dmitri Wiederschain, Ming Yin, Chaomei Shi, Olivier Bedel, Magali Mathieu, Stefan Gross, Aurelie Vassort, Qiang Gao, Frank Le-Strat, Alexey Rak, Bailin Zhang, Junqing Shen, Timothy He, Ying Zhang, Eamonn Rooney, Francisco Adrian, Patricia Gee, Walter Englaro, Hong Cheng, Dietmar Hoffmann, Jean-Pierre Marquette, Larry R. McLean, Jessica McManus, Stuart Licht
Publikováno v:
Journal of Biological Chemistry. 290:762-774
Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric acid, which is proposed to act as an oncogenic metabolite by induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d93999eda17ac20dda53c51b960379
https://doi.org/10.1074/jbc.m114.608497
https://doi.org/10.1074/jbc.m114.608497
Autor:
Jacopo Meldolesi, Eamonn Rooney
Publikováno v:
Journal of Biological Chemistry. 271:29304-29311
Velocity and isopycnic gradient centrifugation were employed to fractionate post-nuclear supernatants rapidly prepared from PC12 cells in order to characterize areas of the endoplasmic reticulum involved in various aspects of intracellular Ca2+ homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032b7314f3badbe2d2234e4885e5cd3f
https://doi.org/10.1074/jbc.271.46.29304
https://doi.org/10.1074/jbc.271.46.29304
Abstract 4746: Selective inhibition of mutant IDH1 via small molecule binding to the dimer interface
Autor:
Ming Yin, Bailin Zhang, Tim He, Stuart Licht, Chaomei Shi, Giang Gao, Dietmar Hoffmann, Hong Cheng, Francisco Adrian, Walter Englaro, Magali Mathieu, Aurelie Vassort, Vinod F. Patel, Stefan Gross, Olivier Bedel, Patricia Gee, Eamonn Rooney, Alexey Rak, Junqing Shen, Dmitri Wiederschain, Yi Li, Jessica McManus, Gejing Deng
Publikováno v:
Cancer Research. 74:4746-4746
Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitric acid to α-ketoglutaric acid (αKG). Point mutations in IDH1 and IDH2 confer a neomorphic enzymatic activity: the reduction of αKG to D-2-hydroxyglutaric acid (2HG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf3621572dabb6a287a156073b7d13d
https://doi.org/10.1158/1538-7445.am2014-4746
https://doi.org/10.1158/1538-7445.am2014-4746