Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Eamonn J Dickson"'
Autor:
Maria Casas, Eamonn J Dickson
Publikováno v:
Neuroscience Insights, Vol 19 (2024)
Cholesterol and calcium play crucial roles as integral structural components and functional signaling entities within the central nervous system. Disruption in cholesterol homeostasis has been linked to Alzheimer’s, Parkinson’s, and Huntington’
Externí odkaz:
https://doaj.org/article/a2dc2c627bc448d19b6d9cd85ffe5cab
Autor:
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simó, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferr
Externí odkaz:
https://doaj.org/article/8e457916b01b415d80b45482e83ca4c6
Autor:
Jonathan D. Horvath, Maria Casas, Candice Kutchukian, Sara Creus Sánchez, Melissa R. Pergande, Stephanie M. Cologna, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113244- (2023)
Summary: Anomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD). Despite its strong link to disease, the precise molecular mec
Externí odkaz:
https://doaj.org/article/ff98fe59a9e9430e909a2ae22edbc46d
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2636-2648.e4 (2019)
Summary: There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the disruption of neuronal homeostasis offer opportunities to unde
Externí odkaz:
https://doaj.org/article/af842f081e254fb1b217713f5615b7a0
Autor:
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ca V 1.2 channels are critical players in cardiac excitation–contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of blood pressure, angiotensin II. Signaling t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15406236833b154135392f21c867579e
https://doi.org/10.1073/pnas.2221242120
https://doi.org/10.1073/pnas.2221242120
Autor:
Eamonn J. Dickson
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031215469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c4d24e409d05cc86329c4c151a050e
https://doi.org/10.1007/978-3-031-21547-6_7
https://doi.org/10.1007/978-3-031-21547-6_7
Publikováno v:
Biophysical Journal. 122:165a-166a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e27d4a0618518f6a45d614fa2bb771
https://doi.org/10.1016/j.bpj.2022.11.1045
https://doi.org/10.1016/j.bpj.2022.11.1045
BackgroundProgressive cardiac hypo-responsivity to β-adrenergic receptor (βAR)-stimulation occurs with aging, diminishing capacity to manage acute stress, and rendering the heart more vulnerable to systemic stressors including hypertension and diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c05d43452071b1043335ce37f73fbbc
https://doi.org/10.1101/2022.08.23.504979
https://doi.org/10.1101/2022.08.23.504979
Autor:
Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille
Publikováno v:
The Journal of general physiology. 154(6)
Phosphoinositide membrane lipids are ubiquitous low-abundance signaling molecules. They direct many physiological processes that involve ion channels, membrane identification, fusion of membrane vesicles, and vesicular endocytosis. Pools of these lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b95fafeb516458aaaf5e2e006e57b82
https://pubmed.ncbi.nlm.nih.gov/35583815
https://pubmed.ncbi.nlm.nih.gov/35583815