Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eamonn Bradley"'
Autor:
Xin Rui Lim, Eamonn Bradley, Gerard P. Sergeant, Keith D. Thornbury, Caoimhin S. Griffin, Mark A. Hollywood
Publikováno v:
British Journal of Pharmacology. 179:1082-1101
Background and purpose Corpus cavernosum smooth muscle (CCSM) exhibits phasic contractions that are coordinated by ion channels. Mouse models are commonly used to study erectile dysfunction, but there are few published electrophysiological studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c744ffc76fa2755e13c81dc5cac8eac0
https://doi.org/10.1111/bph.15728
https://doi.org/10.1111/bph.15728
Autor:
Ruth M, Matthews, Eamonn, Bradley, Caoimhin S, Griffin, Xin Rui, Lim, Nicolas D, Mullins, Mark A, Hollywood, Fionnuala T, Lundy, Lorcan P, McGarvey, Gerard P, Sergeant, Keith D, Thornbury
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Isolated smooth muscle cells (SMCs) from mouse bronchus were studied using the whole cell patch-clamp technique at ∼21°C. Stepping from -100 mV to -20 mV evoked inward currents of mean amplitude -275 pA. These inactivated (tau = 1.1 ms) and were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d42f60eb3033a516e07fc0bc79596a71
https://pubmed.ncbi.nlm.nih.gov/35876287
https://pubmed.ncbi.nlm.nih.gov/35876287
Autor:
Xin Rui, Lim, Eamonn, Bradley, Caoimhin S, Griffin, Mark A, Hollywood, Gerard P, Sergeant, Keith D, Thornbury
Publikováno v:
British journal of pharmacologyREFERENCES. 179(5)
Corpus cavernosum smooth muscle (CCSM) exhibits phasic contractions that are coordinated by ion channels. Mouse models are commonly used to study erectile dysfunction, but there are few published electrophysiological studies of mouse CCSM. We describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe2a964f5f6aaf1ea9f90a014f323e24
https://pubmed.ncbi.nlm.nih.gov/34767251
https://pubmed.ncbi.nlm.nih.gov/34767251
Autor:
Roddy J. Large, Nicholas D. Mullins, Viktoriia Volodymyrivna Bihun, Mark A. Hollywood, Gerard P. Sergeant, Keith D. Thornbury, Eamonn Bradley
Publikováno v:
American Journal of Physiology-Cell Physiology. 315:C818-C829
Airway smooth muscle expresses abundant BKCachannels, but their role in regulating contractions remains controversial. This study examines the effects of two potent BKCachannel openers on agonist-induced phasic contractions in rabbit and mouse bronch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054664c5f7a640dc5d4ab60449cff5a5
https://doi.org/10.1152/ajpcell.00068.2018
https://doi.org/10.1152/ajpcell.00068.2018
Autor:
Domingo Triguero, Eamonn Bradley, Mark A. Hollywood, Angeles Garcia-Pascual, Gerard P. Sergeant, Keith D. Thornbury, Maria Sancho
Publikováno v:
European Journal of Pharmacology. 814:216-225
Cyclic nucleotide-gated (CNG) channels are non-selective cation channels that mediate influx of extracellular Na+ and Ca2+ in various cell types. L-cis-Diltiazem, a CNG channel blocker, inhibits contraction of urethral smooth muscle (USM), however th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ec5dfd3def4fe33fc726a7bd4fb792
https://doi.org/10.1016/j.ejphar.2017.08.020
https://doi.org/10.1016/j.ejphar.2017.08.020
Autor:
Gerard P. Sergeant, Keith D. Thornbury, Roddy J. Large, Eamonn Bradley, Noel G. McHale, T Webb, Stephen Fedigan, Mark A. Hollywood
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 469:1443-1455
Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca2+-activated Cl− currents (I ClCa) that are important for the development of urethral tone. Here, we examined if TMEM16A (ANO1) contributed to this activity by examining t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4358f81e3d8fd71b6cdc5d0ec63b4352
https://doi.org/10.1007/s00424-017-2028-5
https://doi.org/10.1007/s00424-017-2028-5
Autor:
Gerard P. Sergeant, Keith D. Thornbury, Karen I. Hannigan, Noel G. McHale, Roddy J. Large, Eamonn Bradley, Mark A. Hollywood
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C284-C292
Large-conductance Ca2+-activated K+ (BKCa) channels are thought to play a key role in the regulation of corpus cavernosum smooth muscle (CCSM) excitability. Few BKCa channel openers have been accepted for clinical development. The effect of the novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8e8d119b72a5cb831e9fef5ef94693
https://doi.org/10.1152/ajpcell.00273.2015
https://doi.org/10.1152/ajpcell.00273.2015
Autor:
Victoriia Volodymyrivna Bihun, Gerard P. Sergeant, Keith D. Thornbury, Eamonn Bradley, Mark A. Hollywood
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d7624d35b701254a628b871ed1fd73
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb436
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb436
Autor:
Caoimhin S, Griffin, Eamonn, Bradley, Mark A, Hollywood, Noel G, McHale, Keith D, Thornbury, Gerard P, Sergeant
Publikováno v:
BJU international. 121(6)
To test if carbachol (CCh)-evoked CaIsometric tension recordings were made from strips of murine detrusor, and intracellular CaThe RT-PCR and qPCR experiments showed that β1-, β2- and β3-AR were expressed in murine detrusor, but that β3-ARs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdee2ed188114e8c88fa1e180b09fb72
https://pubmed.ncbi.nlm.nih.gov/29878699
https://pubmed.ncbi.nlm.nih.gov/29878699
Autor:
Lorraine Martin, Gerard P. Sergeant, Keith D. Thornbury, Mark A. Hollywood, Eamonn Bradley, Noel G. McHale
Publikováno v:
Airway Pharmacology and Treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::474e4be9ccd70122e6188631f629ac3f
https://doi.org/10.1183/1393003.congress-2017.pa1806
https://doi.org/10.1183/1393003.congress-2017.pa1806