Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Eamonn A, Gaffney"'
Autor:
Clément Moreau, Benjamin J. Walker, Rebecca N. Poon, Daniel Soto, Daniel I. Goldman, Eamonn A. Gaffney, Kirsty Y. Wan
Publikováno v:
Physical Review Research, Vol 6, Iss 4, p L042061 (2024)
We study a slender filament beating in a viscous fluid with novel curvature-dependent bending stiffness. Our numerical and experimental investigations reveal that such differential stiffness can sustain planar bending waves far along flexible filamen
Externí odkaz:
https://doaj.org/article/18b35d372ad94591a573559087bf7ba5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The behaviour of microscopic swimmers has previously been explored near large-scale confining geometries and in the presence of very small-scale surface roughness. Here, we consider an intermediate case of how a simple microswimmer, the tangential sp
Externí odkaz:
https://doaj.org/article/734d443780384ec693fcc3c21b6e74f0
Autor:
Aleksandra E. Kmieciak, Liam V. Brown, Mark C. Coles, Jonathan Wagg, Alex Phipps, Eamonn A. Gaffney
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The spleen, a secondary lymphoid tissue (SLT), has an important role in generation of adaptive immune responses. Although splenectomy remains a common procedure, recent studies reported poor prognosis and increased risk of haematological mal
Externí odkaz:
https://doaj.org/article/fe7cfd469db94e7c966dffd618e7752f
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010112 (2022)
Cell-cell communication is mediated by many soluble mediators, including over 40 cytokines. Cytokines, e.g. TNF, IL1β, IL5, IL6, IL12 and IL23, represent important therapeutic targets in immune-mediated inflammatory diseases (IMIDs), such as inflamm
Externí odkaz:
https://doaj.org/article/f2398cb73db84a9b8000a43ff7df9830
Publikováno v:
Royal Society Open Science, Vol 8, Iss 8 (2021)
With the continuing rapid development of artificial microrobots and active particles, questions of microswimmer guidance and control are becoming ever more relevant and prevalent. In both the applications and theoretical study of such microscale swim
Externí odkaz:
https://doaj.org/article/3f9dd80029b84c65b346ec403d6a8284
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In one of the first examples of how mechanics can inform axonemal mechanism, Machin's study in the 1950s highlighted that observations of sperm motility cannot be explained by molecular motors in the cell membrane, but would instead require motors di
Externí odkaz:
https://doaj.org/article/0a6a02b0ddcc44cb8463148fa46300bf
Publikováno v:
Royal Society Open Science, Vol 7, Iss 6 (2020)
Obstructed by hurdles in information extraction, handling and processing, computer-assisted sperm analysis systems have typically not considered in detail the complex flagellar waveforms of spermatozoa, despite their defining role in cell motility. R
Externí odkaz:
https://doaj.org/article/c966fbecd253472aa2bd06dbea10178e
Autor:
Kenta Ishimoto, Eamonn A. Gaffney
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract We have numerically investigated sperm clustering behaviours, modelling cells as superpositions of regularised flow singularities, coarse-grained from experimentally obtained digital microscopy of human sperm, both in watery medium and a hig
Externí odkaz:
https://doaj.org/article/e9a3a09029894996b5ce36a92df5007e
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
This perspective outlines an approach to improve mechanistic understanding of macrophages in inflammation and tissue homeostasis, with a focus on human inflammatory bowel disease (IBD). The approach integrates wet-lab and in-silico experimentation, d
Externí odkaz:
https://doaj.org/article/ccea25cf36374e4fa84116e061930c20
Autor:
William K W Ho, Lucy Freem, Debiao Zhao, Kevin J Painter, Thomas E Woolley, Eamonn A Gaffney, Michael J McGrew, Athanasia Tzika, Michel C Milinkovitch, Pascal Schneider, Armin Drusko, Franziska Matthäus, James D Glover, Kirsty L Wells, Jeanette A Johansson, Megan G Davey, Helen M Sang, Michael Clinton, Denis J Headon
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000132 (2019)
Feathers are arranged in a precise pattern in avian skin. They first arise during development in a row along the dorsal midline, with rows of new feather buds added sequentially in a spreading wave. We show that the patterning of feathers relies on c
Externí odkaz:
https://doaj.org/article/eaeacd7112b1485b9555e43fb7a6f86d