Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eamon F. X. Byrne"'
Autor:
Maia Kinnebrew, Rachel E. Woolley, T. Bertie Ansell, Eamon F. X. Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S. P. Sansom, Douglas F. Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
Science Advances. 8
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecbac756ffd5793e4e4f0b3695b007b
https://doi.org/10.1126/sciadv.abm5563
https://doi.org/10.1126/sciadv.abm5563
Autor:
Tsukasa Kusakizako, Mikihiro Shibata, Masahiro Fukuda, Tomoko Uemura, Koichiro E. Kishi, Joseph M. Paggi, Keitaro Yamashita, Hideaki E. Kato, Keiichi Inoue, Ron O. Dror, Tyler Benster, Takashi Nagata, So Iwata, Peter Y. Wang, Masae Konno, Toshiki E. Matsui, Charu Ramakrishnan, Kehong Liu, Masatoshi Inoue, Karl Deisseroth, Norimichi Nomura, Elina Thadhani, Yoon Seok Kim, Eamon F. X. Byrne, Osamu Nureki
SummaryChRmine1, a recently-discovered bacteriorhodopsin-like cation-conducting channelrhodopsin1, 2, exhibits puzzling properties (unusually-large photocurrents, exceptional red-shift in action spectrum, and extreme light-sensitivity) that have open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c69d3b2fd614f297e2fb15ea3d4dfaf
https://doi.org/10.1101/2021.08.15.456392
https://doi.org/10.1101/2021.08.15.456392
Publikováno v:
Current Opinion in Cell Biology
The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11ac0deb6c77123365800b7fb59572e
https://doi.org/10.1016/j.ceb.2017.10.004
https://doi.org/10.1016/j.ceb.2017.10.004
The membrane-associated RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface membrane proteins, many of which are involved in immune responses. Although their role in ubiquitin-dependent endocytosis and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc67906636d2d49a3c5bfbcead76099
https://europepmc.org/articles/PMC6378983/
https://europepmc.org/articles/PMC6378983/
Autor:
David R. Raleigh, Michael Grabe, Adam R. Renslo, Philip A. Beachy, Francesc R. Garcia-Gonzalo, Priyadarshini Jaishankar, Libin Xu, Alexis Leigh Krup, Markus Eberl, Sunny Y. Wong, Eamon F. X. Byrne, Navdar Sever, Jeffrey G. McDonald, Bonne M. Thompson, Christian Siebold, Monika Abedin Sigg, Daniel Elnatan, Paola Bisignano, Jeremy F. Reiter, Pervinder K. Choksi, Kelly M. Hines
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular cell, vol 72, iss 2
Molecular Cell
instname
Molecular cell, vol 72, iss 2
Molecular Cell
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136402edca2eaeae20ffc8ae5ad904de
http://hdl.handle.net/10261/188082
http://hdl.handle.net/10261/188082
Autor:
Christian Siebold, Giovanni Luchetti, Rajat Rohatgi, Andreas Sagner, Sigrid Nachtergaele, Jennifer H. Kong, Ria Sircar, Eamon F. X. Byrne, Douglas F. Covey
Publikováno v:
eLife, Vol 5 (2016)
eLife
Luchetti, G, Sircar, R, Kong, J H, Nachtergaele, S, Sagner, A, Byrne, E F, Covey, D F, Siebold, C & Rohatgi, R 2016, ' Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling ', eLife, vol. 5, e20304 . https://doi.org/10.7554/eLife.20304
eLife
Luchetti, G, Sircar, R, Kong, J H, Nachtergaele, S, Sagner, A, Byrne, E F, Covey, D F, Siebold, C & Rohatgi, R 2016, ' Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling ', eLife, vol. 5, e20304 . https://doi.org/10.7554/eLife.20304
Cells must communicate with each other to coordinate the development of most tissues and organs. Damage to these communication systems is often seen in degenerative disorders and in cancer. The Hedgehog signaling pathway is one of a handful of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0c84d914b6c980fe901b8511a30d3b
https://elifesciences.org/articles/20304
https://elifesciences.org/articles/20304
Autor:
Andreas Sagner, Eamon F. X. Byrne, Christian Siebold, Rajat Rohatgi, Ria Sircar, Jennifer H. Kong, Sigrid Nachtergaele, Douglas F. Covey, Giovanni Luchetti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0184d953d9bb22e49f1cab7bb55c0fc9
https://doi.org/10.7554/elife.20304.015
https://doi.org/10.7554/elife.20304.015
Autor:
Eamon F. X. Byrne, Logesvaran Krshnan, Melissa J. Call, Pooja Sharma, Matthew E. Call, Mariam Kaywan-Lutfi
Physical interactions among the lipid-embedded alpha-helical domains of membrane proteins play a crucial role in folding and assembly of membrane protein complexes and in dynamic processes such as transmembrane (TM) signaling and regulation of cell-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2798dd825f70731fc788d6541e7532
https://europepmc.org/articles/PMC3622099/
https://europepmc.org/articles/PMC3622099/
Autor:
Douglas F. Covey, Mark S.P. Sansom, Laurel Mydock-McGrane, Rajat Rohatgi, Sigrid Nachtergaele, Paul S. Miller, George Hedger, Giovanni Luchetti, Mark D. Tully, Eamon F. X. Byrne, Ria Sircar, Christian Siebold, Simon Newstead, Robert P. Rambo
Publikováno v:
Nature
Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the membrane by Frizzledclass G-protein-coupled receptors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6451e5fe752ae77b5f71542344706b