Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eain A. Murphy"'
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Autor:
Kathryn L. Roche, Stacy Remiszewski, Matthew J. Todd, John L. Kulp III, Liudi Tang, Alison V. Welsh, Ashley P. Barry, Chandrav De, William W. Reiley, Angela Wahl, J. Victor Garcia, Micah A. Luftig, Thomas Shenk, James R. Tonra, Eain A. Murphy, Lillian W. Chiang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity ach
Externí odkaz:
https://doaj.org/article/aae26d7a4a0143a6b97410639780fe44
Autor:
Eain A. Murphy
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The necessity of viruses to modulate the innate immune response often dictates the outcome of viral infection. As such, viruses encode many factors that undermine these potent antiviral responses. A recent study by Bouvet et al. (M. Bouvet,
Externí odkaz:
https://doaj.org/article/efe6a716fd994527b6ecd46d65fe125f
Publikováno v:
Viruses, Vol 14, Iss 6, p 1280 (2022)
Human cytomegalovirus (CMV) is a ubiquitous pathogen that latently resides in hematopoietic cells. Latently infected individuals with dysfunctional immune systems often experience CMV reactivation, which can cause devastating disease and mortality. W
Externí odkaz:
https://doaj.org/article/a540565c85e54527bd4424d28d9b06ed
Publikováno v:
Viruses, Vol 14, Iss 2, p 246 (2022)
Long non-coding RNA β2.7 is the most highly transcribed viral gene during latent human cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to β2.7 during HCMV latency. Here we show that β2.7 protects against apopt
Externí odkaz:
https://doaj.org/article/88583671ca0d4c569f6af0de7213d7c6
Autor:
Eui Tae Kim, Kathryn L. Roche, Katarzyna Kulej, Lynn A. Spruce, Steven H. Seeholzer, Donald M. Coen, Felipe Diaz-Griffero, Eain A. Murphy, Matthew D. Weitzman
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 434-448.e6 (2019)
Summary: Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on human cytomegalovirus (HCMV). During HCMV infection, we observe SAMHD1 induct
Externí odkaz:
https://doaj.org/article/1f83d63d11fa48acadd08dbdb7e37633
Publikováno v:
Viruses, Vol 10, Iss 11, p 614 (2018)
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells. However, latently infected individuals with weakened immune s
Externí odkaz:
https://doaj.org/article/a2ebf891e9f24803a801408f7d7e1f75
Publikováno v:
J Virol
Human Cytomegalovirus (HCMV) is a ubiquitous pathogen that has co-evolved with its host and in doing so, is highly efficient in undermining antiviral responses that limit successful infections. As a result, HCMV infections are highly problematic in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25925c23b307e3e4d72169983d9cc31e
https://doi.org/10.1101/2020.01.08.899757
https://doi.org/10.1101/2020.01.08.899757
Autor:
Aharon Nachshon, Sarah E. Jackson, Christopher Huang, Noam Stern-Ginossar, John Sinclair, Fedir Kiskin, Nicholas W. Morrell, Eain A. Murphy, Bin Liu, Anna Basaj, Mark R. Wills, Amer A. Rana, Joy Shih, Gordon Dougan, Baraa Kweider, Emma Poole, Jessica L. Forbester, Dan J. Smith, Kate Roche, Miri Shnayder
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology, Vol 10 (2019)
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89025786a5fe96234bf19dca8a28dbfe
http://europepmc.org/articles/PMC6795026
http://europepmc.org/articles/PMC6795026
Autor:
Amer A. Rana, Aharon Nachson, Emma Poole, Chris Huang, Dan J. Smith, Baraa Kweider, Eain A. Murphy, Gordon Dougan, Kate Roche, Jessica Forbester, Anna Basaj, Sarah E. Jackson, Noam Stern-Ginossar, Miri Shnayder, John Sinclair, Fedir Kiskin, Mark R. Wills
Publikováno v:
Access Microbiology. 1
To date, models of human cytomegalovirus (HCMV) latency and reactivation have depended on the use of primary myeloid cells, which have limited availability, are difficult to culture and are challenging to genetically modify. We now show that induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97d0d8160c6d2940716b222b2bf6b956
https://doi.org/10.1099/acmi.ac2019.po0050
https://doi.org/10.1099/acmi.ac2019.po0050
Publikováno v:
Journal of Virology. 90:4249-4253
The successful colonization of the majority of the population by human cytomegalovirus is a direct result of the virus's ability to establish and, more specifically, reactivate from latency. The underlying cellular factors involved in viral reactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4edb5e2b039fed15c303b041a7a7d6
https://doi.org/10.1128/jvi.02501-15
https://doi.org/10.1128/jvi.02501-15