Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Autor: Huuki-Myers, Louise, Spangler, Abby, Eagles, Nick, Montgomery, Kelsey D., Kwon, Sang Ho, Guo, Boyi, Grant-Peters, Melissa, Divecha, Heena R., Tippani, Madhavi, Sriworarat, Chaichontat, Nguyen, Annie B., Ravichandran, Prashanthi, Tran, Matthew N., Seyedian, Arta, Hyde, Thomas M., Kleinman, Joel E., Battle, Alexis, Page, Stephanie C., Ryten, Mina, Hicks, Stephanie C., Martinowich, Keri, Collado-Torres, Leonardo, Maynard, Kristen R.

Publikováno v: bioRxiv

The molecular organization of the human neocortex has been historically studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally-defined spatial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c7aff8997744ef032dc02cb3d1f83a
https://europepmc.org/articles/PMC9949126/

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex.

Autor: Huuki-Myers L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Spangler A; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Eagles N; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Montgomery KD; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Kwon SH; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA., Guo B; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Grant-Peters M; Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Divecha HR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Tippani M; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Sriworarat C; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA., Nguyen AB; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Ravichandran P; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA., Tran MN; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Seyedian A; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Hyde TM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Kleinman JE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Battle A; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, USA., Page SC; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Ryten M; Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK., Hicks SC; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, USA., Martinowich K; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Collado-Torres L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Maynard KR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 15. Date of Electronic Publication: 2023 Feb 15.