Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche.

Autor: Usui-Ouchi A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Japan., Giles S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; The Lowy Medical Research Institute, La Jolla, California, USA., Harkins-Perry S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; The Lowy Medical Research Institute, La Jolla, California, USA., Mills EA; The Lowy Medical Research Institute, La Jolla, California, USA., Bonelli R; The Lowy Medical Research Institute, La Jolla, California, USA., Wei G; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Ouchi Y; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.; Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba, Japan., Ebihara N; Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Japan., Nakao S; Department of Ophthalmology, Juntendo University, Tokyo, Japan., Friedlander M; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; The Lowy Medical Research Institute, La Jolla, California, USA., Eade KT; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.; The Lowy Medical Research Institute, La Jolla, California, USA.

Publikováno v: Glia [Glia] 2023 Oct; Vol. 71 (10), pp. 2372-2382. Date of Electronic Publication: 2023 Jun 19.

iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.

Autor: Eade KT; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Ansell BRE; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Giles S; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Fallon R; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Harkins-Perry S; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Nagasaki T; Department of Ophthalmology and.; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA., Tzaridis S; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Wallace M; Institute of Food and Health, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland., Mills EA; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Farashi S; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Johnson A; The Lowy Medical Research Institute, La Jolla, California, USA., Sauer L; Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA., Hart B; Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA., Diaz-Rubio ME; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA., Bahlo M; Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Metallo C; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.; Department of Bioengineering, University of California San Diego, La Jolla, California, USA., Allikmets R; Department of Ophthalmology and.; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA., Gantner ML; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA., Bernstein PS; Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA., Friedlander M; The Lowy Medical Research Institute, La Jolla, California, USA.; Department of Molecular Medicine, The Scripps Research Institute (TSRI), La Jolla, California, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 May 01; Vol. 133 (9). Date of Electronic Publication: 2023 May 01.

Forward engineering neuronal diversity using direct reprogramming.

Autor: Tsunemoto RK; The Scripps Research Institute, La Jolla, CA, USA., Eade KT; The Scripps Research Institute, La Jolla, CA, USA., Blanchard JW; The Scripps Research Institute, La Jolla, CA, USA., Baldwin KK; The Scripps Research Institute, La Jolla, CA, USA kbaldwin@scripps.edu.

Publikováno v: The EMBO journal [EMBO J] 2015 Jun 03; Vol. 34 (11), pp. 1445-55. Date of Electronic Publication: 2015 Apr 23.

Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system.

Autor: Eade KT; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Fancher HA, Ridyard MS, Allan DW

Publikováno v: PLoS genetics [PLoS Genet] 2012; Vol. 8 (2), pp. e1002501. Date of Electronic Publication: 2012 Feb 23.