A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer

Autor: Malene Blond Ipsen, Ea Marie Givskov Sørensen, Emil Aagaard Thomsen, Simone Weiss, Jakob Haldrup, Anders Dalby, Johan Palmfeldt, Peter Bross, Martin Rasmussen, Jacob Fredsøe, Søren Klingenberg, Mads R. Jochumsen, Kirsten Bouchelouche, Benedicte Parm Ulhøi, Michael Borre, Jacob Giehm Mikkelsen, Karina Dalsgaard Sørensen

Publikováno v: Ipsen, M B, Sørensen, E M G, Thomsen, E A, Weiss, S, Haldrup, J, Dalby, A, Palmfeldt, J, Bross, P, Rasmussen, M, Fredsøe, J, Klingenberg, S, Jochumsen, M R, Bouchelouche, K, Ulhøi, B P, Borre, M, Mikkelsen, J G & Sørensen, K D 2022, ' A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer ', Oncogene, vol. 41, no. 37, pp. 4271-4281 . https://doi.org/10.1038/s41388-022-02427-2

DNA repair gene mutations are frequent in castration-resistant prostate cancer (CRPC), suggesting eligibility for poly(ADP-ribose) polymerase inhibitor (PARPi) treatment. However, therapy resistance is a major clinical challenge and genes contributin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa56c6bddfaa54653d95a08c997ba684
https://doi.org/10.1038/s41388-022-02427-2