Abstract P4-14-08: Serum concentrations of tamoxifen and Z-endoxifen may predict sexual dysfunction in the 2nd year of adjuvant endocrine treatment

Autor: Gunnar Mellgren, Ea Lien, S Lunde, E Bifulco, BH Gripsrud, K Lode, RA Lind, SS Hustad, J Jonassen, Håvard Søiland, JT Kvaløy, NS Gebreslase, ME Haugstøyl, Emiel A. M. Janssen, Tone Hoel Lende, Turid Aas, Thomas Helland, KB Hagen

Publikováno v: Cancer Research. 79:P4-14

Background and rationale: Side effects of adjuvant treatment with tamoxifen (tam) may impair Quality of Life (QoL) and have been suggested as an independent variable for discontinuation of tam1. There are large inter-patient variabilities in prevalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::525bd65f1703d45a6b3747889acecb9a
https://doi.org/10.1158/1538-7445.sabcs18-p4-14-08

Abstract P2-09-11: Metabolite-guided long-term prediction of outcome in tamoxifen treated breast cancer patients

Autor: SS Hustad, Gunnar Mellgren, Vessela N. Kristensen, Timothy L. Lash, Bjørn Naume, Elin Borgen, Eam Janssen, N Henne, Håvard Søiland, Ea Lien, E Bifulco, Thomas Helland

Publikováno v: Cancer Research. 77:P2-09

Background The genetic polymorphisms of CYP2D6 determine its enzymatic activity thereby the pharmacokinetic velocity by which tamoxifen (tam) is converted into active metabolites. Combined analyses of tam metabolites compared to CYP2D6 type and long-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca7cf6605c9eff31ad916c683c6185c
https://doi.org/10.1158/1538-7445.sabcs16-p2-09-11

Abstract P5-11-14: Distribution of Tamoxifen and Five Metabolites into Normal and Malignant Human Breast Cancer Tissue during Conventional and Low Dose Treatment

Autor: Gunnar Mellgren, Debora Macis, Sara Gandini, Flågeng M. Hauglid, Jennifer Gjerde, Aliana Guerrieri-Gonzaga, B Bonanni, Ea Lien, A. De Censi

Publikováno v: Cancer Research. 70:P5-11

Background: Biotransformation of tamoxifen leads to metabolites with different pharmacological and toxicological effects. Profiling and screening for active metabolites are important to assess their contribution to the overall therapeutic and adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86a6cb691a50f49c030e95b4a82dfb8f
https://doi.org/10.1158/0008-5472.sabcs10-p5-11-14

Associations between tamoxifen and age during steady state tamoxifen treatment of postmenopausal women with breast cancer

Autor: Jennifer Gjerde, Håvard Søiland, Ea Lien

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 121

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0487c2a4952ca4056dfbcb6d29d6e599
https://doi.org/10.1055/s-0033-1336763

Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study.

Autor: Søiland H; Department of Breast and Endocrine Surgery, Stavanger University Hospital, Stavanger, Norway hsoiland@gmail.com.; Department of Clinical Science, University of Bergen, Bergen, Norway., Janssen EAM; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway., Helland T; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Eliassen FM; Department of Breast and Endocrine Surgery, Stavanger University Hospital, Stavanger, Norway., Hagland M; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Nordgård O; Department of Hematology and Oncology, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience, University of Stavanger, Stavanger, Norway., Lunde S; Department of Breast and Endocrine Surgery, Stavanger University Hospital, Stavanger, Norway., Lende TH; Department of Breast and Endocrine Surgery, Stavanger University Hospital, Stavanger, Norway., Sagen JV; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Tjensvoll K; Department of Hematology and Oncology, Stavanger University Hospital, Stavanger, Norway., Gilje B; Department of Oncology, Stavanger University Hospital, Stavanger, Norway., Jonsdottir K; Department of Research, Stavanger University Hospital, Stavanger, Norway., Gudlaugsson E; Department of Pathology, Stavanger University Hospital, Stavanger, Norway., Lode K; Department of Research, Stavanger University Hospital, Stavanger, Norway.; Faculty of Health Sciences Department of Caring and Ethics, University of Stavanger, Stavanger, Norway., Hagen KB; Department of Breast and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway., Gripsrud BH; Faculty of Health Sciences Department of Caring and Ethics, University of Stavanger, Stavanger, Norway., Lind R; Department of Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Heie A; Department of Breast and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway., Aas T; Department of Breast and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway., Austdal M; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Research, Stavanger University Hospital, Stavanger, Norway., Egeland NG; Department of Breast and Endocrine Surgery, Stavanger University Hospital, Stavanger, Norway., Bernklev T; Central Hospital in Vestfold, Tønsberg, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lash TL; Department of Epidemiology, Emory University, Atlanta, Georgia, USA., Skartveit L; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Kroksveen AC; Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway., Oltedal S; Department of Hematology and Oncology, Stavanger University Hospital, Stavanger, Norway., Kvaløy JT; Department of Research, Stavanger University Hospital, Stavanger, Norway.; Mathematics and Physics, Department of Mathematics and Natural Science, University of Stavanger, Stavanger, Norway., Lien EA; Department of Clinical Science, University of Bergen, Bergen, Norway., Sleire L; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway., Mellgren G; Department of Clinical Science, University of Bergen, Bergen, Norway.; Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway.

Publikováno v: BMJ open [BMJ Open] 2022 Apr 29; Vol. 12 (4), pp. e054404. Date of Electronic Publication: 2022 Apr 29.