CYP2C19*17 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban

Autor: Denis Andreev, Oa Baturina, Da Sychev, D. V. Ivashchenko, Ea Grishina, P. O. Bochkov, Eric Rytkin, Kb Mirzaev, R. V. Shevchenko, Ka Ryzhikova

Publikováno v: Pharmacogenomics and Personalized Medicine. 13:29-37

Introduction The aim of this study is to assess the influence of gene CYP2C19, CYP3A4, CYP3A5 and ABCB1 polymorphisms on clopidogrel antiplatelet activity, rivaroxaban concentration equilibrium, and clinical outcomes among patients with acute coronar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f19ac49ba138f1e3cab4f9c6e4eb61fe
https://doi.org/10.2147/pgpm.s234910

CYP2C9 gene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study.

Autor: Sinitsina II; Department of Clinical Pharmacology and Therapeutics, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Boyarko AV; Department of Clinical Pharmacology and Therapeutics, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Temirbulatov II; Department of Clinical Pharmacology and Therapeutics, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.; Laboratory of Human Population Genetics, Research Centre for Medical Genetics, Moscow, Russia., Sychev DA; Department of Clinical Pharmacology and Therapeutics, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Akmalova KA; Department of Molecular Medicine, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Sozaeva ZA; Department of Molecular Medicine, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Grishina EA; Department of Molecular Medicine, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Mirzaev KB; Laboratory of Human Population Genetics, Research Centre for Medical Genetics, Moscow, Russia.; Department of Molecular Medicine, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Asoskova AV; Department of Dermatovenerology and Cosmetology, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Fisenko VP; Department of Pharmacology, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Publikováno v: Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2022 Dec 29; Vol. 38 (2), pp. 163-168. Date of Electronic Publication: 2022 Dec 29 (Print Publication: 2023).

Effect of CYP2D6*4 , CYP2D6*10 polymorphisms on the safety of treatment with timolol maleate in patients with glaucoma.

Autor: Moshetova LK; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Soshina MM; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Turkina KI; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Grishina EA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Sozaeva ZA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Kachanova AA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Akmalova KA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Ivashchenko DV; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.; Penza Branch of Russian Medical Academy of Continuous Professional Education, Penza, Russian Federation., Zastrozhin MS; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Fisenko VP; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Sychev DA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.

Publikováno v: Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2022 Aug 24; Vol. 38 (2), pp. 143-148. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2023).

[Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome].

Autor: Muradian AA; Russian Medical Academy of Continuous Professional Education., Sychev DA; Russian Medical Academy of Continuous Professional Education., Blagovestnov DA; Russian Medical Academy of Continuous Professional Education., Petrov DI; Russian Medical Academy of Continuous Professional Education., Skukin DS; Sklifosovsky Research Institute of Emergency Medicine., Epifanova IP; Russian Medical Academy of Continuous Professional Education., Sozaeva ZA; Russian Medical Academy of Continuous Professional Education., Kachanova AA; Russian Medical Academy of Continuous Professional Education., Denisenko NP; Russian Medical Academy of Continuous Professional Education., Abdullaev SP; Russian Medical Academy of Continuous Professional Education., Grishina EA; Russian Medical Academy of Continuous Professional Education.

Publikováno v: Terapevticheskii arkhiv [Ter Arkh] 2022 Jun 17; Vol. 94 (5), pp. 610-615. Date of Electronic Publication: 2022 Jun 17.

Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder.

Autor: Zastrozhin MS; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Efimova AV; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Skryabin V; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Smirnov VV; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Petukhov AE; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Pankratenko EP; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Pozdniakov SA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Kaverina EV; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Klepikov DA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Grishina EA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Ryzhikova KA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Bure IV; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Bryun EA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia., Sychev DA; Zastrozhin, M.D., PhD, Head of Laboratory of Genetics and Fundamental Studies, Associate Professor of Addiction Psychiatry Department, Bryun, M.D., PhD, Professor, President, Head of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia. Efimova, M.D., Physician of Clinical Department, Balashikha Regional Hospital. Skryabin, M.D., Head of Clinical Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Smirnov, PhD, Associate Professor of Pharmaceutical Toxicology Department, Head of Laboratory of Pharmacokinetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; NRC Institute of Immunology FMBA of Russia, Moscow, Russian Federation. Petukhov, M.D., PhD, Clinical Laboratory Diagnostician of the Analytical Toxicology lab of the Reference Center for Psychoactive Substances use Monitoring, Associate Professor of Pharmaceutical and Toxicological Chemistry, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. Pankratenko, Paramedic-Laboratory Assistant of the Analytical Toxicology Lab of the Reference Center for Psychoactive Substances use Monitoring, Pozdniakov, Researcher of the Laboratory of Genetics and Fundamental Studies, M.D., the Researcher of the Department of Dermatovenerology and Cosmetology, M.D., PhD, Associate Professor of Addiction Psychiatry Department, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russian Federation. Kaverina, M.D., PhD, Associate Professor of the Department of Public Health, Healthcare and Hygiene, Peoples Friendship University of Russia, Moscow, Russian Federation, Peoples Friendship University of Russia. Klepikov, M.D., Assistant Professor of Clinical Pharmacology, Kazakh National Medical University, Almaty, Kazakhstan. Grishina, PhD, Head of Biomolecular Researchers Department of the Research Center, Ryzhikova, Research Fellow of the Biomolecular Researchers Department of the Research Center, Bure, PhD, Research Fellow of the Biomolecular Researchers Department of the Research Center, Sychev, Corresponding Member of the Academy of Sciences of Russia, M.D., PhD, Professor, Rector, Head of Clinical Pharmacology and Therapy Department, Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow, Russia.

Publikováno v: Psychopharmacology bulletin [Psychopharmacol Bull] 2021 Nov 03; Vol. 51 (4), pp. 87-104.