The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice

Autor: Ma, Maldonado, Kakkanaiah V, Gc, Macdonald, Chen F, Ea, Reap, Balish E, Wr, Farkas, John Charles Jennette, Mp, Madaio, Bl, Kotzin, Pl, Cohen, Ra, Eisenberg

Publikováno v: Europe PubMed Central

It has been proposed that the "normal" stimulation of the immune system that occurs from interactions with environmental stimuli, whether infectious or dietary, is necessary for the initiation and/or continuation of autoimmunity. We tested this hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6f696d35a481252e4d3370acefd3d487
http://europepmc.org/abstract/med/10352243

Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.

Autor: Suryadevara CM; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Desai R; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Farber SH; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Choi BD; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Swartz AM; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Shen SH; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Gedeon PC; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Snyder DJ; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Herndon JE 2nd; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Healy P; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Reap EA; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Archer GE; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Fecci PE; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Sampson JH; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu luis.sanchez-perez@duke.edu.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Sanchez-Perez L; Department of Neurosurgery, Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu luis.sanchez-perez@duke.edu.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Jan 01; Vol. 25 (1), pp. 358-368. Date of Electronic Publication: 2018 Nov 13.

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Autor: Reap EA; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Suryadevara CM; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Batich KA; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Sanchez-Perez L; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Archer GE; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Schmittling RJ; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Norberg PK; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Herndon JE 2nd; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Healy P; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Congdon KL; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Gedeon PC; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Campbell OC; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Swartz AM; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Riccione KA; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Yi JS; Division of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina., Hossain-Ibrahim MK; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Saraswathula A; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Nair SK; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Division of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina., Dunn-Pirio AM; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Broome TM; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Weinhold KJ; Division of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina., Desjardins A; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Neurology, Duke University Medical Center, Durham, North Carolina., Vlahovic G; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., McLendon RE; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Friedman AH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Friedman HS; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Bigner DD; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Fecci PE; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Mitchell DA; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu duane.mitchell@neurosurgery.ufl.edu.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Sampson JH; Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu duane.mitchell@neurosurgery.ufl.edu.; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Publikováno v: Cancer research [Cancer Res] 2018 Jan 01; Vol. 78 (1), pp. 256-264. Date of Electronic Publication: 2017 Nov 01.

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.

Autor: Batich KA; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina., Reap EA; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina., Archer GE; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Sanchez-Perez L; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina., Nair SK; Division of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina., Schmittling RJ; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina., Norberg P; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina., Xie W; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina., Herndon JE 2nd; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Healy P; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., McLendon RE; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Friedman AH; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Friedman HS; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Bigner D; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Vlahovic G; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Mitchell DA; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu duane.mitchell@neurosurgery.ufl.edu.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina., Sampson JH; Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina. john.sampson@duke.edu duane.mitchell@neurosurgery.ufl.edu.; Department of Pathology, Duke University Medical Center, Durham, North Carolina.; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina.; Department of Immunology, Duke University Medical Center, Durham, North Carolina.; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Apr 15; Vol. 23 (8), pp. 1898-1909.

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.

Autor: Mitchell DA; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [3] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA., Batich KA; 1] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA., Gunn MD; 1] Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA., Huang MN; Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA., Sanchez-Perez L; Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Nair SK; Division of Surgical Sciences, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Congdon KL; Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Reap EA; Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Archer GE; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Desjardins A; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Friedman AH; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Friedman HS; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Herndon JE 2nd; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA., Coan A; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA., McLendon RE; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA., Reardon DA; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Vredenburgh JJ; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA., Bigner DD; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [3] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA., Sampson JH; 1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [3] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA [4] Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA [5] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Publikováno v: Nature [Nature] 2015 Mar 19; Vol. 519 (7543), pp. 366-9. Date of Electronic Publication: 2015 Mar 11.