Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Autor: Lina Jia, Lihui Wang, Wanyu Sun, Qifan Zhou, Fangyu Du, Guoliang Chen, Dong Xiaoyu

Publikováno v: New Journal of Chemistry. 44:2247-2255

Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d88be765de953288e53e98077b96a790
https://doi.org/10.1039/c9nj04713a

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Autor: Angela Mathison, Usman Yaqoob, Juan Pablo Arab, Vikas K. Verma, Vijay H. Shah, Philippe Mathurin, Gwen Lomberk, Sheng Cao, Rosa Martin-Mateos, Robert C. Huebert, Raul Urrutia, Thomas Greuter, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 197-209 (2019)

Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05485b74c8dd1867da61269d6422e92
https://doi.org/10.1016/j.jcmgh.2018.09.005

Progresses and Pitfalls of Epigenetics in Solid Tumors Clinical Trials.

Autor: Rossi, Alice^1,2 (AUTHOR) alice.rossi@studenti.univr.it, Zacchi, Francesca^1,2 (AUTHOR), Reni, Anna¹ (AUTHOR), Rota, Michele¹ (AUTHOR), Palmerio, Silvia² (AUTHOR), Menis, Jessica¹ (AUTHOR), Zivi, Andrea¹ (AUTHOR), Milleri, Stefano² (AUTHOR), Milella, Michele¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11740. 14p.

Long non-coding RNAs and their implications in cancer epigenetics

Autor: Sergio Verjovski-Almeida, Carlos DeOcesano-Pereira, Felipe Beckedorff, Murilo S. Amaral

Publikováno v: Bioscience Reports, Vol 33, Iss 4, p e00061 (2013)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bioscience Reports

LncRNAs (long non-coding RNAs) have emerged as key molecular players in the regulation of gene expression in different biological processes. Their involvement in epigenetic processes includes the recruitment of histone-modifying enzymes and DNA methy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac8c7f2e713646aa0543a01e0419d3b
http://www.bioscirep.org/bsr/033/e061/bsr033e061.htm

Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells.

Autor: Anestopoulos, Ioannis¹ (AUTHOR) ioannisa@cing.ac.cy, Paraskevaidis, Ioannis¹ (AUTHOR) yiannisparaskevaidis@gmail.com, Kyriakou, Sotiris¹ (AUTHOR) sotirisk@cing.ac.cy, Giova, Lambrini E.¹ (AUTHOR) lamprini.giova@gmail.com, Trafalis, Dimitrios T.² (AUTHOR) dtrafal@med.uoa.gr, Botaitis, Sotiris³ (AUTHOR) smpotait@med.duth.gr, Franco, Rodrigo^4,5 (AUTHOR) rodrigo.franco@unl.edu, Pappa, Aglaia⁶ (AUTHOR) apappa@mbg.duth.gr, Panayiotidis, Mihalis I.¹ (AUTHOR) mihalisp@cing.ac.cy

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2745. 15p.