Zobrazeno 1 - 10
of 96
pro vyhledávání: '"EXO-CD24"'
Autor:
Grigoropoulos, Ioannis1 (AUTHOR), Tsioulos, Georgios1 (AUTHOR), Kastrissianakis, Artemis1 (AUTHOR), Shapira, Shiran2,3 (AUTHOR), Green, Orr2 (AUTHOR), Rapti, Vasiliki4 (AUTHOR), Tsakona, Maria1 (AUTHOR), Konstantinos, Thomas1 (AUTHOR), Savva, Athina1 (AUTHOR), Kavatha, Dimitra1 (AUTHOR), Boumpas, Dimitrios1 (AUTHOR), Syrigos, Konstantinos4 (AUTHOR), Xynogalas, Ioannis4 (AUTHOR), Leontis, Konstantinos4 (AUTHOR), Ntousopoulos, Vasileios4 (AUTHOR), Sakka, Vissaria4 (AUTHOR), Sardelis, Zafeiris5 (AUTHOR), Fotiadis, Andreas5 (AUTHOR), Vlassi, Lamprini5 (AUTHOR), Kontogianni, Chrysoula5 (AUTHOR)
Publikováno v:
Respiratory Research. 4/1/2024, Vol. 25 Issue 1, p1-13. 13p.
Autor:
Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Garyfalia Poulakou, Mina Gaga, Ronan MacLoughlin, Justin Stebbing, Nadir Arber, Anastasia Antoniadou, Sotirios Tsiodras
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Introduction EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than steroids without any
Externí odkaz:
https://doaj.org/article/24f5adc7c431420c90c68b1ab0f43b4a
Autor:
Shapira, Shiran1,2 (AUTHOR) shiransha@tlvmc.gov.il, Schwartz, Reut3,4 (AUTHOR) reuts@tlvmc.gov.il, Tsiodras, Sotirios5 (AUTHOR) sotirios.tsiodras@gmail.com, Bar-Shai, Amir1 (AUTHOR) amirbs@tlvmc.gov.il, Melloul, Ariel1 (AUTHOR) arielmelloul@gmail.com, Borsekofsky, Sarah6 (AUTHOR) sarahbo@tlvmc.gov.il, Peer, Michael7 (AUTHOR) michaelpe@tlvmc.gov.il, Adi, Nimrod3,4 (AUTHOR) nimroda@tlvmc.gov.il, MacLoughlin, Ronan8,9 (AUTHOR) rmacloughlin@aerogen.com, Arber, Nadir1,2,3 (AUTHOR) nadira@tlvmc.gov.il
Publikováno v:
International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p77. 15p.
Autor:
Shiran Shapira, Reut Schwartz, Sotirios Tsiodras, Amir Bar-Shai, Ariel Melloul, Sarah Borsekofsky, Michael Peer, Nimrod Adi, Ronan MacLoughlin, Nadir Arber
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 77 (2023)
Acute Respiratory Distress Syndrome (ARDS) is a major health concern with urgent unmet need for treatment options. There are three million new ARDS cases annually, and the disease’s mortality rate is high (35–46%). Cluster of differentiation 24 (
Externí odkaz:
https://doaj.org/article/1049a6b9e3104dfc866b68ffd0ace78f
Akademický článek
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Autor:
Shiran Shapira, Marina Ben Shimon, Mori Hay‐Levi, Gil Shenberg, Guy Choshen, Lian Bannon, Michael Tepper, Dina Kazanov, Jonathan Seni, Shahar Lev‐Ari, Michael Peer, Dimitrios Boubas, Justin Stebbing, Sotirios Tsiodras, Nadir Arber
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-17 (2022)
Abstract A small but significant proportion of COVID‐19 patients develop life‐threatening cytokine storm. We have developed a new anti‐inflammatory drug, EXO‐CD24, a combination of an immune checkpoint (CD24) and a delivery platform (exosomes
Externí odkaz:
https://doaj.org/article/e8cb646be73748bdab517e8146718ff6
Autor:
Orr Green, Gil Shenberg, Roni Baruch, Lihi Argaman, Talya Levin, Ian Michelson, Ruthy Hadary, Boris Isakovich, Miri Golos, Reut Schwartz, Ronan MacLoughlin, Nimrod Adi, Nadir Arber, Shiran Shapira
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2523 (2023)
Rationale: Acute respiratory distress syndrome (ARDS) is a major global health concern with a significant unmet need. EXO-CD24 is delivered via inhalation-reduced cytokines and chemokine secretion and lung injury in ARDS and improved survival in mice
Externí odkaz:
https://doaj.org/article/279f02338c0d4c76b4e8338848d39cc4
Akademický článek
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Autor:
Shapira S; Health Promotion Center and Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; Department of Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel., Schwartz R; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Anesthesia and Intensive Care Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., Tsiodras S; 4th Department of Internal Medicine, University General Hospital Attikon, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Bar-Shai A; Health Promotion Center and Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., Melloul A; Health Promotion Center and Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., Borsekofsky S; Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., Peer M; Department of Chest Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., Adi N; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Anesthesia and Intensive Care Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel., MacLoughlin R; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons, D02 YN77 Dublin, Ireland.; School of Pharmacy and Pharmaceutical Sciences, Trinity College, D02 PN40 Dublin, Ireland., Arber N; Health Promotion Center and Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; Department of Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 20; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 20.
Autor:
Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Nadir Arber, Garyfallia Poulakou, Konstantinos Syrigos, Vasiliki Rapti, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Mina Gaga, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Maria Tsakona, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Anastasia Antoniadou, Sotirios Tsiodras
Publikováno v:
Open Forum Infectious Diseases. 9
Background EXO-CD24 is a novel inhaled drug of exosomes displaying CD24, a protein with anti-inflammatory properties. We evaluated the safety and potential efficacy of EXO-CD24, in a phase II, randomized, single-blinded clinical trial of EXO-CD24 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d967e4befa8a8f9d4cf7b1907fa704
https://doi.org/10.1093/ofid/ofac492.991
https://doi.org/10.1093/ofid/ofac492.991