Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Autor: Ki Hoon Kim, Jeong Hyun Jo, Hye Jin Cho, Tae Sub Park, Tae Min Kim

Publikováno v: Laboratory Animal Research, Vol 36, Iss 1, Pp 1-7 (2020)

Abstract Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived E

Externí odkaz: https://doaj.org/article/f133d7c4700b4ce9836e54d35c283d99

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

Autor: Qin Xu, Bin Tu, Yongzhuo Huang, Pengfei Zhao, Huiyuan Wang, Hong Qiu, Canhao Wu, Jiaxin Zeng, Mingjie Shi

Publikováno v: Acta Pharmaceutica Sinica. B

The spread of coronavirus disease 2019 (COVID-19) throughout the world has resulted in stressful healthcare burdens and global health crises. Developing an effective measure to protect people from infection is an urgent need. The blockage of interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7799e07530f67b3903b68db258a426
https://doi.org/10.1016/j.apsb.2021.09.004

Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche

Autor: Tadahito Yasuda, Hideo Baba, Takatsugu Ishimoto

Publikováno v: Regenerative Therapy, Vol 17, Iss, Pp 8-12 (2021)
Regenerative Therapy

Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6e792e0488411d444bcff6479bbf43
https://doi.org/10.1016/j.reth.2021.01.005

Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics

Autor: Karsten Vestergård, Jesper F. Havelund, Nils J. Færgeman, Shona Pedersen, Charlotte Held Gotfredsen, Raluca Maltesen, Søren Risom Kristensen, Jonas Ellegaard Nielsen

Publikováno v: Metabolism Open, Vol 12, Iss, Pp 100125-(2021)
Nielsen, J E, Maltesen, R G, Havelund, J F, Færgeman, N J, Gotfredsen, C H, Vestergård, K, Kristensen, S R & Pedersen, S 2021, ' Characterising Alzheimer's disease through integrative NMR-and LC-MS-based metabolomics ', Metabolism Open, vol. 12, 100125 . https://doi.org/10.1016/j.metop.2021.100125
Nielsen, J E, Maltesen, R G, Havelund, J F, Færgeman, N J, Gotfredsen, C H, Vestergård, K, Kristensen, S R & Pedersen, S 2021, ' Characterising Alzheimer's disease through integrative NMR-and LC-MS-based metabolomics ', Metabolism open, vol. 12, 100125 . https://doi.org/10.1016/j.metop.2021.100125
Metabolism Open

Background: Alzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein regulations and might reflect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36710fd7cf80b8c201090924500ca109
http://www.sciencedirect.com/science/article/pii/S2589936821000499

Phosphorylated Rasal2 facilitates breast cancer progression

Autor: Christopher Qian, Zhong-Ming Qian, Ya Ke, Yinlong Yang, Meng-Yue Liu, Xuan Wang

Publikováno v: EBioMedicine
EBioMedicine, Vol 50, Iss, Pp 144-155 (2019)

Background: Rasal2 has diametric effects on progression of oestrogen receptor-positive (ER+) and -negative (ER–) breast cancers. The relevant causes are unknown. It is also unknown whether the effects of Rasal2 are mediated by an exosome-transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1090a02f13557b5ae9f81d7c7653b5be
http://europepmc.org/articles/PMC6921363