Zobrazeno 1 - 10
of 2 040
pro vyhledávání: '"EVOLUTIONARY CONSERVATION"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Elucidating the dynamics of gene expression across developmental stages, including the genomic characteristics of brain expression during infancy, is pivotal in deciphering human psychiatric and neurological disorders and providin
Externí odkaz:
https://doaj.org/article/59909c54b2dd4a7db8fda85819518850
Autor:
Hui Luo, Wen-Yan Gong, Yuan-Yuan Zhang, Ying-Ying Liu, Zhen Chen, Xing-Lin Feng, Qi-Bin Jiao, Xing-Wei Zhang
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39011- (2024)
Inositol-requiring enzyme 1 (IRE1), a mediator of the unfolded protein response, shows the highest degree of evolutionary conservation. Vertebrates express two IRE1 paralogs: IRE1α, which is universally expressed and IRE1β, which shows specific exp
Externí odkaz:
https://doaj.org/article/c68c0fbc8ae641648ebcd63843143366
Autor:
Owen Dando, Jamie McQueen, Karen Burr, Peter C. Kind, Siddharthan Chandran, Giles E. Hardingham, Jing Qiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Rodent studies have shown that alternative splicing in neurons plays important roles in development and maturity, and is regulatable by signals such as electrical activity. However, rodent-human similarities are less well explored. We compared basal
Externí odkaz:
https://doaj.org/article/ce260b833ff24902a5ce953b3917db8a
Autor:
Deepyaman Das, Anis Ahmad Chaudhary, Mohamed A. M. Ali, Abdullah S. Alawam, Hironmoy Sarkar, Soumita Podder
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2290-2305 (2023)
Initiation of meiosis in budding yeast does not commit the cells for meiosis. Thus, two distinct signaling cascades may differentially regulate meiosis initiation and commitment in budding yeast. To distinguish between the role of these signaling cas
Externí odkaz:
https://doaj.org/article/b48683982f574bbdada380af142dcbd2
Publikováno v:
Genes and Diseases, Vol 10, Iss 5, Pp 2038-2048 (2023)
NK2 genes (NKX2 gene cluster in humans) encode for homeodomain-containing transcription factors that are conserved along the phylogeny. According to the most detailed classifications, vertebrate NKX2 genes are classified into two distinct families, N
Externí odkaz:
https://doaj.org/article/5d68afc05502474cacc461a3e0e1e92e
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Open reading frames (ORFs) with fewer than 100 codons are generally not annotated in genomes, although bona fide genes of that size are known. Newer biochemical studies have suggested that thousands of small protein-coding ORFs (smORFs) may
Externí odkaz:
https://doaj.org/article/bf694cb5885e4c2bb89a72040d4326de
Publikováno v:
EvoDevo, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Background Phenotypic evolution is mainly explained by selection for phenotypic variation arising from factors including mutation and environmental noise. Recent theoretical and experimental studies have suggested that phenotypes with greate
Externí odkaz:
https://doaj.org/article/05fa3eefa70245ad9428e7f8fdef52bb
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Two main subclasses of macrophages are found in almost all solid tissues: embryo-derived resident tissue macrophages and bone marrow-derived infiltrated macrophages. These macrophage subtypes show transcriptional and functional di
Externí odkaz:
https://doaj.org/article/c5eb686c6ef3451f8685d7e01f58751a
Autor:
Anders A. Jensen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In contrast to the other pentameric ligand-gated ion channels in the Cys-loop receptor superfamily, the ZACN gene encoding for the Zinc-Activated Channel (ZAC) is exclusively found in the mammalian genome. Human ZAC assembles into homomeric cation-se
Externí odkaz:
https://doaj.org/article/d9e4a751df1d469699c18d4f5edec2b2
Autor:
José G. Ortiz, Robert Gerlai
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/8aa014fe472a4b5e99a97f85afcf8056