Neurotoxicology

Autor: Michael R. Dobbs, Mam Ibraheem, Dong Y. Han

Publikováno v: Neurologic Clinics. 38:737-748

Clinical neurotoxicology is an unrecognized neurologic subspecialty. Few neurology residency programs offer an organized education or training in the field. Nevertheless, neurotoxic exposures and subsequent injuries are common. This article provides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::951f1d5f312fac0ad15f4e3866de982a
https://doi.org/10.1016/j.ncl.2020.06.001

Adverse outcome pathways: opportunities, limitations and open questions

Autor: Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung

Publikováno v: Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f557dd7872bdda32c94a20832dbd6
https://doi.org/10.1007/s00204-017-2045-3

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Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes

Autor: Virginia Zaunbrecher, Ila Cote, Patrick Allard, Timothy F. Malloy, Joel Tickner, Raymond Tice, Ann Blake, Hilary A. Godwin, Kristina A. Thayer, Margaret H. Whittaker, Kelly D. Moran, Mark Rossi, Ken Zarker, Jakub Kostal, Lauren Heine, Elizabeth Beryt, Gary E. Marchant, Patrick Kerzic, Andre E. Nel, Richard S. Judson, Jennifer McPartland, Oladele A. Ogunseitan

Publikováno v: Integrated Environmental Assessment and Management. 13:915-925

Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b82bd335b2d2ed70bbc08f0cad58ae6c
https://doi.org/10.1002/ieam.1923