Receptor binding mechanism and immune evasion capacity of SARS-CoV-2 BQ.1.1 lineage.

Autor: Wang C; School of Biomedical Sciences, Hunan University, Changsha, China., Zhang Y; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Yang C; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Ren W; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Qiu C; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Fan S; Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Ding Q; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Lan J; School of Biomedical Sciences, Hunan University, Changsha, China. Electronic address: lanjun2022@hnu.edu.cn.

Publikováno v: Virology [Virology] 2024 Dec; Vol. 600, pp. 110241. Date of Electronic Publication: 2024 Sep 10.

SARS-CoV-2 omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1.

Autor: Wang Q; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Pandemic Research Alliance unit at the Wu Family Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Guo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Schwanz LT; Department of Pathobiology and Mechanisms of Disease, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Mellis IA; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Sun Y; Department of Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Qu Y; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Urtecho G; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Valdez R; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Stoneman E; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Gordon A; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Wang HH; Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Pandemic Research Alliance unit at the Wu Family Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Liu L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, People's Republic of China.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2359004. Date of Electronic Publication: 2024 May 31.

CD47 and thrombospondin-1 contribute to immune evasion by Porphyromonas gingivalis .

Autor: Angabo S; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Pandi K; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., David K; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Steinmetz O; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Makkawi H; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Farhat M; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Eli-Berchoer L; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Darawshi N; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel., Kawasaki H; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel.; Central Research Institute, Wakunaga Pharmaceutical Co. Ltd., Hiroshima 739-1195, Japan., Nussbaum G; Institute of Biomedical and Oral Research, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem 91120, Israel.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 19; Vol. 121 (47), pp. e2405534121. Date of Electronic Publication: 2024 Nov 13.

A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2.

Autor: An R; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yang H; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Tang C; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Li Q; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China.; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China., Huang Q; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Wang H; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Wang J; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Zhou Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yang Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Chen H; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yu W; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Li B; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Wu D; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Zhang Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Luo F; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Quan W; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Xu J; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Lin D; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Liang X; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yan Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yuan L; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Du X; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Yuan Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Li Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China., Sun Q; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. qsun@imbcams.com.cn.; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. qsun@imbcams.com.cn.; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. qsun@imbcams.com.cn.; Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Kunming, China. qsun@imbcams.com.cn., Wang Y; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. wangyc@nifdc.org.cn.; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. wangyc@nifdc.org.cn.; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. wangyc@nifdc.org.cn., Lu S; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China. lushuaiyao-km@163.com.; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. lushuaiyao-km@163.com.; State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. lushuaiyao-km@163.com.; Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Kunming, China. lushuaiyao-km@163.com.

Publikováno v: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Nov 06; Vol. 9 (1), pp. 301. Date of Electronic Publication: 2024 Nov 06.

Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis-Independent Mechanism.

Autor: Wu R; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Li J; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Aicher A; Precision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, No. 91, Xueshi Road, Taichung, 404, Taiwan.; Immunology Research and Development Center, China Medical University, No. 91, Xueshi Road, Taichung, 404, Taiwan., Jiang K; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Tondi S; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Strada Provinciale 142 Km 3,95, Candiolo (TO), 10060, Italy., Dong S; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Zheng Q; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Tang S; School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China., Chen M; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Guo Z; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Šabanović B; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Strada Provinciale 142 Km 3,95, Candiolo (TO), 10060, Italy., Ananthanarayanan P; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Strada Provinciale 142 Km 3,95, Candiolo (TO), 10060, Italy., Jiang L; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Sapino A; Department of Pathology, Candiolo Cancer Institute - FPO - IRCCS, Strada Provinciale 142 Km 3,95, Candiolo (TO), 10060, Italy., Wen C; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Fu D; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Shen B; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China., Heeschen C; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, P. R. China.; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Strada Provinciale 142 Km 3,95, Candiolo (TO), 10060, Italy.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Nov; Vol. 11 (42), pp. e2308990. Date of Electronic Publication: 2024 Sep 19.