Structural analysis unravels the functional promiscuity of Quinolone synthase-mediated polyketide biosynthesis in Aegle marmelos Correa

Autor: Mallika Vijayanathan, KV Abhinav, Debashree Bandyopadhyay, Kozhinjampara R Mahendran, Abdoallah Sharaf, M Radhakrishna Pillai, EV Soniya

Quinolone synthase from Aegle marmelos (AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone compounds. Based on the high-resolution protein structure of AmQNS, this study provided a mechanistic explan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17a6ba88e1232a69f68a195653acf601
https://doi.org/10.1101/2022.08.26.505429

Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity.

Autor: Vijayanathan M; Transdisciplinary Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.; Department of Plant and Environment Sciences, University of Copenhagen, 1871, Frederiksberg C, Denmark., Vadakkepat AK; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.; Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE17HB, UK., Mahendran KR; Transdisciplinary Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Sharaf A; SequAna Core Facility, Department of Biology, University of Konstanz, Konstanz, Germany.; Genetic Department, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt., Frandsen KEH; Department of Plant and Environment Sciences, University of Copenhagen, 1871, Frederiksberg C, Denmark., Bandyopadhyay D; Department of Biological Sciences, Birla Institute of Technology and Science, Hyderabad, India., Pillai MR; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India., Soniya EV; Transdisciplinary Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India. evsoniya@rgcb.res.in.

Publikováno v: Communications biology [Commun Biol] 2024 May 14; Vol. 7 (1), pp. 566. Date of Electronic Publication: 2024 May 14.

Identification of nitric oxide mediated defense signaling and its microRNA mediated regulation during Phytophthora capsici infection in black pepper.

Autor: Asha S; Transdisciplinary Biology, Plant Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala India.; Present Address: Department of Molecular Biology and Biotechnology, College of Agriculture, Vellayani, Kerala Agricultural University, Thiruvananthapuram, India., Kattupalli D; Transdisciplinary Biology, Plant Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala India., Vijayanathan M; Transdisciplinary Biology, Plant Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala India.; Present Address: Department of Plant and Environmental Sciences, University of Copenhagen, Capital Region, Denmark., Soniya EV; Transdisciplinary Biology, Plant Disease Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala India.

Publikováno v: Physiology and molecular biology of plants : an international journal of functional plant biology [Physiol Mol Biol Plants] 2024 Jan; Vol. 30 (1), pp. 33-47. Date of Electronic Publication: 2024 Feb 11.

Phytophthora capsici infection causes dynamic alterations in tRNA modifications and their associated gene candidates in black pepper.

Autor: Usha A; Transdisciplinary Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India., Kattupalli D; Transdisciplinary Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India., Viswam P; Transdisciplinary Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India., Bharathan S; Transdisciplinary Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India., Soniya EV; Transdisciplinary Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Nov 04; Vol. 20, pp. 6055-6066. Date of Electronic Publication: 2022 Nov 04 (Print Publication: 2022).

Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development.

Autor: Girija A; Department of Transdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.; Institute of Biological Environmental Rural Sciences (IBERS), Aberystwyth University, United Kingdom., Vijayanathan M; Department of Transdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.; Biology Centre - Institute of Plant Molecular Biology, Czech Academy of Sciences, České Budějovice, 370 05, Czech Republic., Sreekumar S; Department of Transdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.; Research Centre, University of Kerala, India., Basheer J; School of Biosciences, Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India.; Department of Cell Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacky University, Olomouc, Czech Republic., Menon TG; Department of Transdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India., Krishnankutty RE; School of Biosciences, Mahatma Gandhi University, PD Hills, Kottayam, Kerala, India., Soniya EV; Department of Transdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.

Publikováno v: Current molecular pharmacology [Curr Mol Pharmacol] 2022; Vol. 15 (2), pp. 265-291.