Výsledky vyhledávání

Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model

Autor: Hyeok Yil Kwon, Yeon Joo Choi, Ji In Yong, Duk-Soo Kim, Sung-Woo Cho, Min Jea Shin, Won Sik Eum, Eun Ji Ryu, Hyun Ju Cha, Eun Hee Ahn, Dae Won Kim, Keunwook Lee, Seok Young Chung, Soo Young Choi, Jinseu Park, Sang Jin Kim, Yoon Shin Cho

Publikováno v: International Journal of Molecular Medicine. 38:217-224

Antioxidant 1 (ATOX1) functions as an antioxidant against hydrogen peroxide and superoxide, and therefore may play a significant role in many human diseases, including diabetes mellitus (DM). In the present study, we examined the protective effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85b1884f2c6f9d700f2511abf15b2d
https://doi.org/10.3892/ijmm.2016.2599

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Effects of low doses of Tat-PIM2 protein against hippocampal neuronal cell survival

Publikováno v: Journal of the Neurological Sciences. 358:226-235

Oxidative stress is considered a major factor in various neuronal diseases including ischemia-reperfusion injury. Proviral Integration Moloney 2 (PIM2) proteins, one of the families of PIM kinases, play crucial roles in cell survival. However, the fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de4733f113a8ecef58ccbfc55586259
https://doi.org/10.1016/j.jns.2015.08.1549

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PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways

Publikováno v: Molecular medicine reports. 18(2)

Oxidative stress is known to be a primary risk factor for neuronal diseases. Glutaredoxin (GLRX)‑1, a redox‑regulator of the thioredoxin superfamily, is known to exhibit an important role in cell survival via various cellular functions. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcdefa3453ae83874a11b25bfad7fd8
https://pubmed.ncbi.nlm.nih.gov/29916538

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Neuroprotective effects of PEP-1-carbonyl reductase 1 against oxidative-stress-induced ischemic neuronal cell damage

Autor: Hyo Young Jung, Eun Ji Ryu, In Koo Hwang, Young Nam Kim, Chi Hern Lee, Won Sik Eum, Dae Won Kim, Jung Hoon Choi, Min Jea Shin, Jinseu Park, Ji In Yong, Eun Hee Ahn, Soo Young Choi, Sang Jin Kim

Publikováno v: Free Radical Biology and Medicine. 69:181-196

Human carbonyl reductase 1 (CBR1) is a member of the NADPH-dependent short-chain dehydrogenase/reductase superfamily that is known to play an important role in neuronal cell survival via its antioxidant function. Oxidative stress is one of the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cedda5100c2b2f270ac3484f0d65ff1
https://doi.org/10.1016/j.freeradbiomed.2014.01.006

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PEP-1–SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages

Autor: Hyeon Ji Yeo, Eun Ji Ryu, Sung-Woo Cho, Jiye Hyeon, Won Sik Eum, Jung Hwan Park, Sang Jin Kim, Chi Hern Lee, Kyu Hyung Han, Yoon Shin Cho, Jinseu Park, Ora Son, Duk-Soo Kim, Mi Jin Kim, Soo Young Choi, Su Bin Cho, Dae Won Kim, Ji In Yong

Publikováno v: Free Radical Biology and Medicine. 63:432-445

Sirtuin 2 (SIRT2), a member of the sirtuin family of proteins, plays an important role in cell survival. However, the biological function of SIRT2 protein is unclear with respect to inflammation and oxidative stress. In this study, we examined the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea11e06acd8c074604cba53bfc741a7
https://doi.org/10.1016/j.freeradbiomed.2013.06.005

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Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways

Publikováno v: International journal of molecular medicine. 38(1)

Oxidative stress-induced apoptosis is associated with neuronal cell death and ischemia. The NOL3 [nucleolar protein 3 (apoptosis repressor with CARD domain)] protein protects against oxidative stress-induced cell death. However, the protective mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0bee3754275de4e4694f2935029955
https://pubmed.ncbi.nlm.nih.gov/27221790

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Tat-antioxidant 1 protects against stress-induced hippocampal HT-22cells death and attenuate ischaemic insult in animal model

Autor: Keun Wook Lee, Dae Won Kim, Oh-Shin Kwon, Min Jea Shin, Won Sik Eum, Soo Young Choi, Kyu Hyung Han, So Mi Kim, Eun Ji Ryu, Yoon Shin Cho, In Koo Hwang, Jinseu Park, Sung-Woo Cho, Dae Young Yoo, Hyo Sang Jo, Ji In Yong, Eun Hee Ahn

Publikováno v: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE(19): 6
Journal of Cellular and Molecular Medicine

Oxidative stress-induced reactive oxygen species (ROS) are responsible for various neuronal diseases. Antioxidant 1 (Atox1) regulates copper homoeostasis and promotes cellular antioxidant defence against toxins generated by ROS. The roles of Atox1 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c1229f4abcb5870df412819a0d1394
http://open-repository.kisti.re.kr/cube/handle/open_repository/485608.do

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Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice

Autor: Hyeon Ji Yeo, Sang Jin Kim, Min Jea Shin, Jong Kyu Youn, Sung-Woo Cho, Dae Won Kim, Hyun Ju Cha, Hyo Sang Jo, Eun Hee Ahn, Duk-Soo Kim, Jae Hyeok Hwang, Ji-Heon Jeong, Eun Ji Ryu, Ji In Yong, Won Sik Eum, Soo Young Choi, Young Nam Kim, Jinseu Park

Publikováno v: Toxicology and applied pharmacology. 286(2)

Human carbonyl reductase 1 (CBR1) plays a crucial role in cell survival and protects against oxidative stress response. However, its anti-inflammatory effects are not yet clearly understood. In this study, we examined whether CBR1 protects against in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3364f6755d6e4fc0e3681e6dcc161d38
https://pubmed.ncbi.nlm.nih.gov/25818598

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