Zobrazeno 1 - 10
of 107
pro vyhledávání: '"ETC, electron transport chain"'
Autor:
David A. Frank, Isidora Tošić
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436
http://europepmc.org/articles/PMC8569436
Autor:
John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6b
https://doi.org/10.1016/j.jacbts.2021.07.004
https://doi.org/10.1016/j.jacbts.2021.07.004
Autor:
Margarita Gerou, Benjamin A. Hall, Scott P. Allen, Kathrin Meyer, Pamela J. Shaw, Ryan Woof, Jessica Allsop, Stephen J. Kolb
Publikováno v:
Neurobiology of Aging
Highlights • Aging affects the metabolic profile of fibroblasts derived from ALS cases • Increased NADH metabolism with age is observed in the presence of a specific set of catabolic energy substrates in healthy individuals • Reduced NADH metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa322bad33369b41380c3947538e1343
http://europepmc.org/articles/PMC8346650
http://europepmc.org/articles/PMC8346650
Autor:
Aldons J. Lusis, Raquel Floyd, Simon Sabir, Miklós Péterfy, Paola León-Mimila, Anthony E. Jones, Linsey Stiles, Dulshan W. Jayasekera, Samuel Canizales-Quinteros, Adriana Huertas-Vazquez, Varun Shravah, Angel A. Cortez, Karthickeyan Chella Krishnan, Ajit S. Divakaruni
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 2
Cellular and molecular gastroenterology and hepatology, vol 11, iss 2
Background & Aims The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly understood, with males and certain populations exhibiting markedly increased susceptibility. Using a systems genetics approach involving multi-omic analysis of ∼10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4127e52760363929df8a11fd651eca
http://europepmc.org/articles/PMC7788245
http://europepmc.org/articles/PMC7788245
Autor:
Hani N. Sabbah
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 88-106 (2020)
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 88-106 (2020)
Visual Abstract
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mito
Highlights • Cardiac energy deprivation due to mitochondrial dysfunction is characteristic of heart failure. • Mitochondrial dysfunction contributes to worsening of the heart failure state. • Pharmacologic targeting of mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf223c5fc74d0943fdde83a16b2755
http://europepmc.org/articles/PMC7000886
http://europepmc.org/articles/PMC7000886
Autor:
David A. Hanna, Roshan Kumar, Aditi Gupta, Marouane Libiad, Jace W. Jones, Victor Vitvitsky, Ruma Banerjee, Sebastián Carballal
Publikováno v:
The Journal of Biological Chemistry
Mammalian cells synthesize H2S from sulfur-containing amino acids and are also exposed to exogenous sources of this signaling molecule, notably from gut microbes. As an inhibitor of complex IV in the electron transport chain, H2S can have a profound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4126c798519bf53806142328813d474
http://europepmc.org/articles/PMC8342795
http://europepmc.org/articles/PMC8342795
Autor:
Sukriti Baweja, Shiv Kumar Sarin, Shvetank Sharma, Richard Moreau, Saggere Muralikrishna Shasthry, Jaswinder Singh Maras
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100283-(2021)
JHEP Reports
JHEP Reports
Background & Aims In patients with severe alcoholic hepatitis (SAH), little is known about the profile of peripheral blood mononuclear cells (PBMCs) at baseline and during corticosteroid therapy, among those who can be treated successfully with stero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feac4b8cd659d574b1edf099c19c5bcf
http://www.sciencedirect.com/science/article/pii/S2589555921000598
http://www.sciencedirect.com/science/article/pii/S2589555921000598
Publikováno v:
Toxicology Reports, Vol 6, Iss, Pp 1164-1175 (2019)
Toxicology Reports
Toxicology Reports
Autism is the category used within the newest edition of the diagnostic and statistical manual of neurodevelopmental disorders. Autism is a spectrum of disorder where a variety of behavioural patterns observed in autistic patients, such as stereotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c345a0a3ef7e4a37973c156afa9598
http://www.sciencedirect.com/science/article/pii/S2214750019303610
http://www.sciencedirect.com/science/article/pii/S2214750019303610
Autor:
Patrick Yu-Wai-Man, Christoph Ufer, Lynn Bedford, David J. Boocock, Theodosis S. Theodosi, Aslihan Ugun-Klusek, Julia C. Fitzgerald, E. Ellen Billett, Florence Burté
Publikováno v:
Redox Biology, Vol 20, Iss, Pp 167-181 (2019)
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee6c7f7a07ce2d77e3885777776be6e
http://www.sciencedirect.com/science/article/pii/S2213231718307341
http://www.sciencedirect.com/science/article/pii/S2213231718307341
Autor:
Krishna K. Varadhan, Dileep N. Lobo, Paul L. Greenhaff, Dumitru Constantin-Teodosiu, Despina Constantin, Ryan P. Atkins
Publikováno v:
Clinical Nutrition (Edinburgh, Scotland)
© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60f297c96e45ed8ad162f41f06b8100
