Identification of High-Risk Multiple Myeloma With a Plasma Cell Leukemia-Like Transcriptomic Profile.

Autor: Hofste Op Bruinink D; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.; Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands., Kuiper R; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.; SkylineDx, Rotterdam, the Netherlands., van Duin M; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Cupedo T; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., van der Velden VHJ; Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands., Hoogenboezem R; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., van der Holt B; HOVON Data Center, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Beverloo HB; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands., Valent ET; SkylineDx, Rotterdam, the Netherlands., Vermeulen M; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Gay F; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Broijl A; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Avet-Loiseau H; Unité de Génomique du Myélome, IUC-Oncopole, Toulouse, France., Munshi NC; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Musto P; 'Aldo Moro' University School of Medicine, Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Italy., Moreau P; Hematology Department, University Hospital Hôtel-Dieu, Nantes, France., Zweegman S; Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands., van de Donk NWCJ; Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands., Sonneveld P; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2022 Sep 20; Vol. 40 (27), pp. 3132-3150. Date of Electronic Publication: 2022 Mar 31.

Prognostic gene expression analysis in a retrospective, multinational cohort of 155 multiple myeloma patients treated outside clinical trials.

Autor: Chen YT; SkylineDx, Rotterdam, The Netherlands., Valent ET; SkylineDx, Rotterdam, The Netherlands., van Beers EH; SkylineDx, Rotterdam, The Netherlands., Kuiper R; SkylineDx, Rotterdam, The Netherlands., Oliva S; Myeloma Unit, Division of Hematology, University of Turin, Turin, Italy., Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany., Chng WJ; National University Cancer Institute, National University Health System, Singapore City, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore., van Vliet MH; SkylineDx, Rotterdam, The Netherlands., Sonneveld P; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Larocca A; Myeloma Unit, Division of Hematology, University of Turin, Turin, Italy.

Publikováno v: International journal of laboratory hematology [Int J Lab Hematol] 2022 Feb; Vol. 44 (1), pp. 127-134. Date of Electronic Publication: 2021 Aug 26.

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.

Autor: van der Stoel M; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., Schimmel L; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands., Nawaz K; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands., van Stalborch AM; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands., de Haan A; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., Klaus-Bergmann A; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), 10785 Berlin, Germany., Valent ET; Amsterdam UMC, Free University, location VUMC, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands., Koenis DS; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., van Nieuw Amerongen GP; Amsterdam UMC, Free University, location VUMC, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands., de Vries CJ; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., de Waard V; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., Gloerich M; University Medical Center Utrecht, Center for Molecular Medicine, Dept. Molecular Cancer Research, 3584 CX Utrecht, The Netherlands., van Buul JD; Sanquin Research and Landsteiner Laboratory, Department of Molecular and Cellular Hemostasis, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.; Leeuwenhoek Centre for Advanced Microscopy (LCAM), section Molecular Cytology at Swammerdam Institute for Life Sciences (SILS) at University of Amsterdam, 1098 XH Amsterdam, The Netherlands., Huveneers S; Amsterdam UMC, University of Amsterdam, location AMC, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands s.huveneers@amsterdamumc.nl.

Publikováno v: Journal of cell science [J Cell Sci] 2020 Feb 12; Vol. 133 (3). Date of Electronic Publication: 2020 Feb 12.

ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension.

Autor: Beckers CM; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands., Knezevic N; Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, College of Medicine, Chicago, IL 60612, USA., Valent ET; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands., Tauseef M; Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, College of Medicine, Chicago, IL 60612, USA., Krishnan R; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Rajendran K; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Hardin CC; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Aman J; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands., van Bezu J; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands., Sweetnam P; Surface Logix-737, Concord Ave., Cambridge, MA 02138, USA., van Hinsbergh VW; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands., Mehta D; Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, College of Medicine, Chicago, IL 60612, USA., van Nieuw Amerongen GP; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands; Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois, College of Medicine, Chicago, IL 60612, USA. Electronic address: nieuwamerongen@vumc.nl.

Publikováno v: Vascular pharmacology [Vascul Pharmacol] 2015 Jul; Vol. 70, pp. 45-54. Date of Electronic Publication: 2015 Apr 11.