Výsledky vyhledávání - "ESTELA M.F. MURI"

Akademický článek

New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity

Autor: RAQUEL R.S. SALVADOR, MURILO L. BELLO, IGOR R.L. BARRETO, MARIA A.F. VERA, ESTELA M.F. MURI, SÉRGIO DE ALBUQUERQUE, LUIZA R.S. DIAS

Publikováno v: Anais da Academia Brasileira de Ciências, Iss 0

ABSTRACT This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds wer

Externí odkaz: https://doaj.org/article/e9ebd4f728da48ed83c5b83a72f04335

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Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs

Autor: Sergio Pinheiro, Erick M.C. Pinheiro, Sandro J. Greco, Jaqueline C. Pessôa, Mayara A. Cadorini, Estela M.F. Muri

Publikováno v: Medicinal Chemistry Research. 29:1751-1776

The [1,2,4]triazolo[1,5-a]pyrimidines (TPs) comprise an important class of non-naturally occurring small molecules that aroused the interest of researches. This scaffold is present in diverse important structures in agriculture and medicinal chemistr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0a44750b22878aa69dff666dc175414
https://doi.org/10.1007/s00044-020-02609-1

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3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7

Autor: Sergio Pinheiro, Estela M.F. Muri, Barbara D.C. Pacheco, Luciano Puzer, Bruno E.G. de Souza, Mariana B.M. de Moraes, Rafael Garrett, Luiza R.S. Dias, Camilo Henrique da Silva Lima, Acácio S. de Souza

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:1094-1098

Human kallikreins 5 and 7 (KLK5 and KLK7) exhibit trypsin- and chymotrypsin-like activities and are involved in pathologies related to skin desquamation process. A series of new 3-acyltetramic acids were developed as a novel class of inhibitors of KL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1e0b1e355711c876cc50db063e0c1d
https://doi.org/10.1016/j.bmcl.2019.02.031

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Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: synthesis, in vitro and in vivo studies

Autor: Gisele Bulhões Portapilla, Luiza R.S. Dias, Júlio C. A. V. Soares, Estela M.F. Muri, Camilo Henrique da Silva Lima, Maiara Voltarelli Providello, Sérgio de Albuquerque, Joana Lucius de Sousa Ribeiro

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Despite the serious public health problems caused by Chagas disease in several countries, the available therapy remains with only two drugs that are poorly active during the chronic phase of the disease in addition to having severe side effects. In s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326202b3ea4243d9053566a539950666

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Biological evaluation and molecular modeling of peptidomimetic compounds as inhibitors for O-GlcNAc transferase (OGT)

Autor: Thalita G. Barros, Luiz A.P. Flores-Junior, Luiza R.S. Dias, Suraby O. Albuquerque, Wagner B. Dias, Hector F. Loponte, Estela M.F. Muri, Adriane R. Todeschini, Eldio Gonçalves dos Santos, Pedro H.R. de A. Azevedo, Sergio Pinheiro, Camilo Henrique da Silva Lima

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 154

The vital enzyme O-linked β-N-acetylglucosamine transferase (OGT) catalyzes the O-GlcNAcylation of intracellular proteins coupling the metabolic status to cellular signaling and transcription pathways. Aberrant levels of O-GlcNAc and OGT have been l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f66e30097ae364ada6794e40adf5cf
https://pubmed.ncbi.nlm.nih.gov/32801002

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Anti-Trypanosoma cruzi activity and molecular docking studies of 1Hpyrazolo[ 3, 4-b]pyridine derivatives

Autor: Camilo Henrique da Silva Lima, Sérgio de Albuquerque, Luiza R.S. Dias, Estela M.F. Muri, Júlio C. A. V. Soares, Joana Lucius de Sousa Ribeiro

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background: Untargeted studies led to the development of some pyrazolopyridine derivatives for the antiparasitic profile, particularly the derivatives containing the structural carbohydrazide subunit. In this work, we proceeded in the biological scre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86b46223b6cc263a143798113b70133

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Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5

Autor: Lucas Villas Bôas Hoelz, Marcelo B. Zani, Lucas R. de Souza, Luiza R.S. Dias, Sergio Pinheiro, Silvia G. Passos, Bruna C. Zorzanelli, Pedro H.R. de A. Azevedo, Luciano Puzer, Estela M.F. Muri

Publikováno v: European Journal of Medicinal Chemistry. 112:39-47

Human kallikrein 5 (KLK5) is a potential target for the treatment of skin inflammation and cancer. A new series of statine based peptidomimetic compounds were designed and synthesized through simple and efficient reactions. Some KLK5 inhibitors (2a-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6abb669a29bd6ae72c32310f6f5760
https://doi.org/10.1016/j.ejmech.2016.01.060

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2H-1,2,3-Triazole-chalcones as novel cytotoxic agents against prostate cancer

Autor: Carlos M.D. Silva Junior, Laiza B. Loureiro, Karin J.P. Rocha-Brito, Sandro J. Greco, Sergio Pinheiro, Estela M.F. Muri, Karina M. Rotamiro, Rodolfo G. Fiorot, Eclair Venturini Filho, Maria Clara R. Freitas, Anderson R.A. Guimarães, Erick M.C. Pinheiro, José Walkimar de M. Carneiro, Jaqueline C. Pessôa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:127454

Prostate cancer is an important cause of death in the male population and for which there is no satisfactory chemotherapy. Herein a new series of chalcone hybrids containing 2H-1,2,3-triazole core as the ring B has been synthesized and evaluated in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ae588ed24d4ede55d6055d5f82155
https://doi.org/10.1016/j.bmcl.2020.127454

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Molecular dynamics simulations of the free and inhibitor-bound cruzain systems in aqueous solvent: insights on the inhibition mechanism in acidic pH

Autor: Lucas Villas Bôas Hoelz, Magaly Girão Albuquerque, Carlos Rangel Rodrigues, Estela M.F. Muri, Luiza R.S. Dias, Pedro G. Pascutti, Vinícius Fonseca Leal

Publikováno v: Journal of Biomolecular Structure and Dynamics. 34:1969-1978

The major cysteine protease of Trypanosoma cruzi, cruzain (CRZ), has been described as a therapeutic target for Chagas' disease, which affects millions of people worldwide. Thus, a series of CRZ inhibitors has been studied, including a new competitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a67133f8ad91b013fa700ff81b8d14
https://doi.org/10.1080/07391102.2015.1100139

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