Výsledky vyhledávání - "ESTEFANIA ROJAS"

Akademický článek

IGFBP3 methylation is a novel diagnostic and predictive biomarker in colorectal cancer.

Autor: Lucia Perez-Carbonell, Francesc Balaguer, Yuji Toiyama, Cecilia Egoavil, Estefania Rojas, Carla Guarinos, Montserrat Andreu, Xavier Llor, Antoni Castells, Rodrigo Jover, C Richard Boland, Ajay Goel

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104285 (2014)

Aberrant hypermethylation of cancer-related genes has emerged as a promising strategy for the development of diagnostic, prognostic and predictive biomarkers in human cancer, including colorectal cancer (CRC). The aim of this study was to perform a s

Externí odkaz: https://doaj.org/article/05c8a15f9cbd4cf3913f1b00a5dd905d

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A new species and a new record for Cedrela (Meliaceae, Sapindales) in Ecuador: morphological, molecular, and distribution evidence

Autor: WALTER A. PALACIOS, MARIA DE LOURDES TORRES, MARTINA ALBUJA QUINTANA, PACARINA ASADOBAY, JUAN IGLESIAS, RICHARD QUILLUPANGUI, ESTEFANIA ROJAS, JANETH SANTIANA, AUGUSTO SOLA, GONZALO RIVAS-TORRES

A new Cedrela (Meliaceae) species, Cedrela angusticarpa, is described through a combination of taxonomic, morphological, and molecular analyses. Cedrela kuelapensis, originally described as an endemic species of northern Peru, is also reported here a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3202e374f5c5de4f355cb89bbf86592
https://zenodo.org/record/7905812

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Data from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Autor: Ajay Goel, C. Richard Boland, Antoni Castells, Xavier Llor, Montserrat Andreu, Francesc Balaguer, Cristina Alenda, Estefania Rojas, Eva Hernández-Illán, Miriam Juárez, Lucia Perez-Carbonell, Cecilia Egoavil, Rodrigo Jover, Oscar Murcia

Purpose: A recent study reported that 5-fluorouracil (5-FU)-based chemotherapy is less effective in treating patients with advanced colorectal cancer demonstrating hypermethylation of the TFAP2E gene. The aim of our study was to confirm and validate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dbea501a83cf50f8b529096f5ce5b8
https://doi.org/10.1158/1078-0432.c.6525716.v1

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Supp Figure 4 from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Supplementary Figure 4. Epicolon I. Overall Survival Stage IV Patients: TFAP2E IHC Expression. Disease Free Survival Stage II and III Patients: TFAP2E IHC Expression. (A) Overall survival of patients with stage IV disease, according to TFAP2E express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c18a5718bed4aba2394cfb10756257d
https://doi.org/10.1158/1078-0432.22464425

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Supp Figure 3 from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Supplementary Figure 3. Correlation between TFAP2E intron 3 methylation and IHC expression. When methylation was analysed as a continuous variable using linear regression analysis, we observed a trend towards negative correlation with IHC protein exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401cff78e7eb3cedf405838fb60cafba
https://doi.org/10.1158/1078-0432.22464428

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Additional figures and tables from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Supplementary data Supplementary Methods Supplementary Table 1. Characteristics of Epicolon I patients (n=532) Supplementary Table 2. Characteristics of Clinical cohort patients (n=251) Supplementary Table 3. Primer sequences Supplementary Figure 1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a32c0f927b95957ba14fa43bf37bed3
https://doi.org/10.1158/1078-0432.22464437.v1

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Supplemental Figure 1 from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Supplementary Figure 1. Schematic representation of TFAP2E gene. The gene encoding transcription factor AP-2 epsilon (TFAP2E) is located on chromosome 1p34. In the schematic overview, exons are represented by blue boxes and introns with blue lines. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b4db557cc7027a8164e014566fe1b8
https://doi.org/10.1158/1078-0432.22464422

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Supp Figure 2 from TFAP2E Methylation and Expression Status Does Not Predict Response to 5-FU-based Chemotherapy in Colorectal Cancer

Supplementary Figure 2. Methylation analysis of TFAP2E CpG islands in CRC tissues. Calculation of cutoff value of TFAP2E Intron 3 methylation. Results comparing methylation of the TFAP2E CpG1 (Promoter/Exon 1) and CpG2 (Intron 3) in CRC tissues (N=50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a934f2e61084649743df358d5f1f4f3b
https://doi.org/10.1158/1078-0432.22464434

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