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Clinical Applications of the Areas under ESPVR: A Review

Autor: Rachad M. Shoucri

Relations between the ejection fraction (EF), parameters describing the end-systolic pressure-volume relation (ESPVR) and the areas under the ESPVR are derived for a linear model of the ESPVR. The active pressure generated by the myocardium during an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd3e2e327a089e4885a6d7c8415a1bc
https://doi.org/10.9734/bpi/hmmr/v10/8602d

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Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

Autor: John Reardon, J. Craig Hartman, Kefei Zhang, Carlos del Rio, Hani N. Sabbah

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803069b3001ba958ec9683326d90c4ae
https://doi.org/10.1016/j.jacbts.2018.07.003

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Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Autor: Giana Schena, Steven R. Houser, Danielle M. Trappanese, Daohai Yu, Jon C. George, Jeffery D. Molkentin, Hajime Kubo, Tim Starosta, Remus M. Berretta, Alexander R. Hobby, Markus Wallner, Thomas E. Sharp

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)
JACC: Basic to Translational Science

Visual Abstract
Highlights • Acute protein kinase A α (PKCα) inhibition with ruboxistaurin reduces heart size post-myocardial infarction. • Acute PKCα inhibition with ruboxistaurin increases contractility post-myocardial infarction. • P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732927aa6f50eb927b8ed0bcd5b35c8
http://www.sciencedirect.com/science/article/pii/S2452302X17301559

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Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal

Autor: Atsushi Miyanohara, Zhen Tan, N. Chin Lai, Dimosthenis Giamouridis, Mei Hua Gao, H. Kirk Hammond, W. Matthijs Blankesteijn, Young Chul Kim, Erik A.L. Biessen, Tracy Guo

Publikováno v: JACC Basic to translational science 3(2), 249-264 (2018). doi:10.1016/j.jacbts.2017.12.004
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
JACC: Basic to Translational Science, 3(2), 249-264. Elsevier
JACC: Basic to Translational Science

Visual Abstract
Highlights • UCn2 and UCn3 gene transfer increased LV peak +dP/dt (systolic function) and LV peak −dP/dt (diastolic function) significantly and similarly. • Both genes increased LV levels of SERCA2a, and isolated cardiac my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67e30518cf30bff80774cca74b02ab7

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End-systolic Pressure-Volume Relation, Ejection Fraction, and Heart Failure: Theoretical Aspect and Clinical Applications

Autor: Rachad M. Shoucri

Publikováno v: Clinical Medicine Insights. Cardiology
Clinical Medicine Insights: Cardiology, Vol 2015, Iss Suppl. 1, Pp 111-120 (2015)
Clinical Medicine Insights: Cardiology, Vol 9s1 (2015)

A mathematical formalism describing the nonlinear end-systolic pressure–volume relation (ESPVR) is used to derive new indexes that can be used to assess the performance of the heart left ventricle by using the areas under the ESPVR (units of energy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc9955ce322d6df742a6a6426b592c1
https://pubmed.ncbi.nlm.nih.gov/26244035

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