Molecular Signature of HFpEF

Autor: John W. Elrod, Steven R. Houser, Markus Wallner, Remus M. Berretta, Dhanendra Tomar, Anh T Huynh, Joanne F Garbincius, Deborah M Eaton, Emma K Murray, Devin W. Kolmetzky, Andrew A. Gibb

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • Early cardiac mitochondrial dysfunction is mediated by transcriptional down-regulation of the mitochondrial proteome. • Comprehensive metabolic remodeling is conserved throughout HFpEF progression and includes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474acd63270db1077349e2d878112f6b
https://doi.org/10.1016/j.jacbts.2021.07.004

Direct detection of OXA-48-like carbapenemase variants with and without co-expression of an extended-spectrum β-lactamase from bacterial cell lysates using mass spectrometry

Autor: Scott R. Kronewitter, James L. Stephenson, Arvind Verma, William M. McGee, Jason R. Neil, Marjaana Viirtola

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 25-34 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • LC-MS methods are used to identify intact OXA-48 like enzymes from bacterial lysates. • Individual protein variants of the OXA-48 like carbapenemases can be detected with tandem mass spectrometry. • OXA-48 like carbapenemases can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7805096e04f78395d3d7e73173308107
http://www.sciencedirect.com/science/article/pii/S2667145X21000080

Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach

Autor: Bojana Rakic, Hilary Vallance, Joshua A. Dubland, Graham Sinclair

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 1-10 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • Analysis of 2-methylcitric acid, methylmalonic acid, and homocysteine in DBS. • A dual derivatization LC-MS/MS strategy developed for use in second-tier NBS. • Second-tier panel replaces multiple initial follow-up tests. • Improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50beebd48c7a916d499a13356b9284c0
https://doi.org/10.1016/j.jmsacl.2021.03.001

Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage

Autor: Chuyao Liao, Di Wang, Ying Zhang, Zunjian Zhang, Fengguo Xu, Siyuan Qin, Yuxin Zhang, Danting Li, Yuan Tian, Jie Chen

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 763-780 (2021)
Acta Pharmaceutica Sinica. B

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af930bc5ea3c9fbae9d582539b35a5f
https://doi.org/10.1016/j.apsb.2020.07.017

Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification

Autor: Harald John, Horst Thiermann

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 19, Iss, Pp 20-31 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • Evidence of poisoning with organophosphorus (OP) nerve agents requires biomedical verification. • OP nerve agents undergo common biotransformation pathways producing valuable biomarkers. • Internationally accepted methods target re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41b5a1b0825181b488f72690c50353f
http://www.sciencedirect.com/science/article/pii/S2667145X21000018