ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

Autor: Kai Feng, Teng Ye, Xuetao Xie, Jiashuo Liu, Liangzhi Gong, Zhengsheng Chen, Juntao Zhang, Haiyan Li, Qing Li, Yang Wang

Publikováno v: Pharmacological Research, Vol 209, Iss , Pp 107474- (2024)

Osteoarthritis (OA) is a common joint degenerative disease which currently lacks satisfactory disease-modifying treatments. Oxidative stress-mediated senescent chondrocytes accumulation is closely associated with OA progression, which abrogates carti

Externí odkaz: https://doaj.org/article/ed22f2581c8042109a068143184ac69c

ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia

Autor: Yuguo Xia, Yang Wang, Yu Chen, Bizeng Zhao, Guowen Hu, Ji Yuan, Qing Li, Xin Niu, Juntao Zhang, Zhifeng Deng

Publikováno v: Advanced Science, Vol 7, Iss 10, Pp n/a-n/a (2020)
Advanced Science

Vascular dementia (VD) is one of the most common types of dementia, however, the intrinsic mechanism is unclear and there is still lack of effective medications. In this study, the VD rats exhibit a progressive cognitive impairment, as well as a time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75827c49bfcf34eb0ad6f9608d3be8f
https://doaj.org/article/8f9b1a05cbc34123813e1dbe61059bfd

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ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis.

Autor: Feng K; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Ye T; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Xie X; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Liu J; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Gong L; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Chen Z; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Zhang J; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China., Li H; Chemical and Environmental Engineering, School of Engineering, STEM College, RMIT University, 124 La Trobe St, Melbourne, VIC 3000, Australia., Li Q; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address: liqing_236@aliyun.com., Wang Y; Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address: wangyang63@sjtu.edu.cn.

Publikováno v: Pharmacological research [Pharmacol Res] 2024 Oct 19; Vol. 209, pp. 107474. Date of Electronic Publication: 2024 Oct 19.