Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains

Autor: Zhen Li, Xianbin Tian, Lilian Kisiswa, Ajeena Ramanujan, Ning Zhang, Carlos F. Ibáñez, Wensu Yuan, Zhi Lin, Eunice Weiling Sim

Publikováno v: Zhang, N, Kisiswa, L, Ramanujan, A, Li, Z, Sim, E W, Tian, X, Yuan, W, Ibáñez, C F & Lin, Z 2021, ' Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains ', Journal of Biological Chemistry, vol. 297, no. 2, 100916 . https://doi.org/10.1016/j.jbc.2021.100916
The Journal of Biological Chemistry

The p75 neurotrophin receptor (p75NTR) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases and cancers. The death domain (DD) of p75NTR is an intracellular signaling hub and has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0bbd2cb844bf0783353c7d641f4ec8
https://pure.au.dk/portal/da/publications/structural-basis-of-nfb-signaling-by-the-p75-neurotrophin-receptor-interaction-with-adaptor-protein-tradd-through-their-respective-death-domains(955eafca-a0a5-442c-8b0e-8eceffee7ca1).html

A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice

Autor: Wei Wei, Zhigang Liu, Chao Zhang, Rami Khoriaty, Min Zhu, Bin Zhang

Publikováno v: The Journal of Biological Chemistry

SEC23B is one of two vertebrate paralogs of SEC23, a key component of the coat protein complex II vesicles. Complete deficiency of SEC23B in mice leads to perinatal death caused by massive degeneration of professional secretory tissues. However, func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e451add9825cedad54eb1e03a007f1a
https://doi.org/10.1016/j.jbc.2021.101536

The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis

Autor: Mitsuyo Matsumoto, Hironari Nishizawa, Yuriko Saiki, Kazuhiko Igarashi

Publikováno v: The Journal of Biological Chemistry

The progression of cancer involves not only the gradual evolution of cells by mutations in DNA but also alterations in the gene expression induced by those mutations and input from the surrounding microenvironment. Such alterations contribute to canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93ddeab3e30d4b92868b229475d7a4b
https://doi.org/10.1016/j.jbc.2021.101032

Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex

Autor: Itsuki Ajioka

Publikováno v: Regenerative Therapy
Regenerative Therapy, Vol 3, Iss C, Pp 63-67 (2016)

The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938e5a5bdfe8f372965ac7ff5ce5139

Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption

Autor: Douglas G. Mashek, Kayleigh R. O'Keeffe, Andrew S. Greenberg, Qing-Wu Yan, Elizabeth A. Killion, Deanna M. Salter, Theresa D’Aquila, Thomas A. Bowman, Kimberly K. Buhman, John D. Griffin

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 3, Pp 210-220 (2016)

Objective The family of acyl-CoA synthetase enzymes (ACSL) activates fatty acids within cells to generate long chain fatty acyl CoA (FACoA). The differing metabolic fates of FACoAs such as incorporation into neutral lipids, phospholipids, and oxidati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b396d4d8d615d903c724bf29d7421fec
https://doi.org/10.1016/j.molmet.2016.01.001