Zobrazeno 1 - 10
of 352
pro vyhledávání: '"ERNEST HODGSON"'
Autor:
Anirudh Dhammi, R. Michael Roe, Roger D. Lawrie, Ernest Hodgson, Andrew D. Wallace, Robert D. Mitchell
Publikováno v:
Pesticide biochemistry and physiology. 167
Human exposure to environmental chemicals both individually and in combination occurs frequently world-wide most often with unknown consequences. Use of molecular approaches to aide in the assessment of risk involved in chemical exposure is a growing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53159647e0b6330ed23fe44f4ec02f4
https://pubmed.ncbi.nlm.nih.gov/32527422
https://pubmed.ncbi.nlm.nih.gov/32527422
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 30:375-395
New paradigms for human health risk assessment of environmental chemicals emphasize the use of molecular methods and human-derived cell lines. In this study, we examined the effects of the insect repellent DEET (N,N-diethyl-m-toluamide) and the pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7f1b1bb678cbb2549598fbafb7776aa
https://doi.org/10.1002/jbt.21801
https://doi.org/10.1002/jbt.21801
Autor:
Robert C. Smart, Ernest Hodgson
Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.• Links traditional toxi
Autor:
Sharon A. Meyer, Ernest Hodgson
Pesticides are ubiquitous contaminants of the human environment and, as such, interact with hepatic enzymes as substrates, inhibitors, and inducers. Exposure of the general public to pesticides is usually low but not necessarily without toxicity. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dddf91a98e36c4eacccd104a3e6b8dfe
https://doi.org/10.1016/b978-0-12-801238-3.02109-7
https://doi.org/10.1016/b978-0-12-801238-3.02109-7
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 10, p 2104 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 10; Pages: 2104
International Journal of Molecular Sciences, Vol 18, Iss 10, p 2104 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 10; Pages: 2104
While the synthesis and use of new chemical compounds is at an all-time high, the study of their potential impact on human health is quickly falling behind, and new methods are needed to assess their impact. We chose to examine the effects of two com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c9e3c175fe226050882c4b6f454b84
http://europepmc.org/articles/PMC5666786
http://europepmc.org/articles/PMC5666786
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 28:1-10
The new paradigms proposed for human health risk assessment stress the need for the use of human and human-derived cell lines, and this review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de33c38d51cc4173cca91611fcf83b26
https://doi.org/10.1002/jbt.21534
https://doi.org/10.1002/jbt.21534
Publikováno v:
Toxicology. 276:184-191
Chlorpyrifos, an organophophorothioate insecticide, is bioactivated to the neurotoxic metabolite, chlorpyrifos-oxon (CPO) by cytochromes P450 (CYPs). To determine the variability in chlorpyrifos bioactivation, CPO production by human liver microsomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709032d8aa1f23f2f32bfc5bad14af3e
https://doi.org/10.1016/j.tox.2010.08.005
https://doi.org/10.1016/j.tox.2010.08.005
Publikováno v:
Pesticide Biochemistry and Physiology. 98:73-79
Atrazine (ATZ) metabolism by human liver microsomes (HLM), cytochrome P450 (CYP) isoforms, and human liver (HL) S9 fractions, was investigated using HPLC/PDA and LC/MS/MS. CYP-dependent metabolites from pooled HLM are desethylatrazine (DEA), desisopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e8870d7bcf006015aee9a553d8071d
https://doi.org/10.1016/j.pestbp.2010.05.002
https://doi.org/10.1016/j.pestbp.2010.05.002
Autor:
Ernest Hodgson, Michael Roe
Dictionary of Toxicology, Third Edition presents a compendium of definitions of all current toxicological terminology. This authoritative reference illustrates and describes words, concepts, acronyms and symbols for both the toxicological theory and
Autor:
Randy L. Rose, Ernest Hodgson
Publikováno v:
Pest Management Science. 64:617-621
Agrochemicals and other xenobiotics are metabolized by xenobiotic-metabolizing enzymes (XMEs) to products that may be more or less toxic than the parent chemical. In this regard, phase-I XMEs such as cytochrome P450s (CYPs) are of primary importance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f8d8dc85cc25febf18863b11f4ce5f
https://doi.org/10.1002/ps.1563
https://doi.org/10.1002/ps.1563