Zobrazeno 1 - 10 of 72 pro vyhledávání: '"ERK1-2 Pathway"'
1
Akademický článek
The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review
Autor: Yarlla Loyane Lira Braga, José Rodrigues do Carmo Neto, Pablo Igor Ribeiro Franco, Fernanda Rodrigues Helmo, Marlene Antônia dos Reis, Flávia Aparecida de Oliveira, Mara Rúbia Nunes Celes, Marcos Vinícius da Silva, Juliana Reis Machado
Publikováno v: Journal of Cardiovascular Development and Disease, Vol 11, Iss 2, p 65 (2024)
Fibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure. Interleukin (IL)-11 is regulated in various
Externí odkaz: https://doaj.org/article/418c22f902f94ffcba9620837b40f279
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2
Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1/2 pathway
Autor: Jianjin Guo, Qian Zhao, Kaini Zhang, Chen Qiu, Kai Li, Yikun Zhu, Jinfeng Chen, Wei Zhang, Dongming Su, Wei Ren
Publikováno v: Biochemical and Biophysical Research Communications. 529:277-282
Background Tangeretin, a flavonoid derived from citrus peel, showed anti-diabetic effects. However, the role of tangeretin on liver, the organ that act as target of insulin and play the central role in maintaining the blood glucose level control, is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bac5b7cffb8530c44505750ddcaa9c
https://doi.org/10.1016/j.bbrc.2020.05.212
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3
Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells
Autor: Jianping Ye, Xinyu Cao, Yongning Sun, Xiaotong Ye, Li Ma
Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:1407-1415
Purpose Glucagon-like peptide-1 (GLP-1) is secreted from the intestinal L-cells to stimulate insulin secretion in the blood glucose control. Our previous study indicates that Sennoside A (SA) can increase the plasma GLP-1 level in a mouse model of ty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4a5ac3b59608aecc00c09bf65043ad3
https://doi.org/10.2147/dmso.s247251
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4
Emodin Protects SH-SY5Y Cells Against Zinc-Induced Synaptic Impairment and Oxidative Stress Through ERK1/2 Pathway
Autor: Chencen Lai, Qian Chen, Zhi Tang, Fa Chen, Ruiqing Ni, Yiyuan Zhou, Yuanting Ding, Songbai Su
Background: Zinc is an essential trace element important for the physiological function of the central nervous system. The abnormal accumulation of zinc inside neurons may induce mitochondrial dysfunction and oxidative stress which contributes to man
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a635d5560a9ea79adabb8b4ea6cfb8df
https://doi.org/10.21203/rs.3.rs-829075/v1
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5
Effects of Caveolin-1-ERK1/2 pathway on endothelial cells and smooth muscle cells under shear stress
Autor: Lihua Wang, Bo Wang, Fang Wei, Chen Li, Aili Jiang, Haiyan Chen, Zhe Wang, Lan Jia, Haibo Yu
Publikováno v: Exp Biol Med (Maywood)
Hemodynamic forces have an important role in venous intimal hyperplasia, which is the main cause of arteriovenous fistula dysfunction. Endothelial cells (ECs) constantly exposed to the shear stress of blood flow, converted the mechanical stimuli into
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea55c008622d0fa1eadf2c04b9c33cdd
https://doi.org/10.1177/1535370219892574
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8
Akademický článek
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10
Abstract 14232: The Cathepsin D-m6pr-erk1/2 Pathway Mediates Cellular Senescence and Osteogenic Activities in Human Aortic Valve Interstitial Cells
Autor: Qingzhou YAO, Erlinda The, Lihua Ao, Yufeng Zhai, David A Fullerton, Xianzhong Meng
Publikováno v: Circulation. 142
Background: Calcific aortic valve disease (CAVD) is one of the most prevalent cardiovascular disorders in the elderly, and aortic valve interstitial cells (AVICs) play a major role in valvular calcification associated with CAVD progression. Recent st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f8801f891b10d191d355cdf820b96fa
https://doi.org/10.1161/circ.142.suppl_3.14232
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