Zobrazeno 1 - 10
of 36
pro vyhledávání: '"ERK1/2 (extracellular signal regulated kinase 1/2)"'
Autor:
Nemat Ali, Fawaz Alasmari, Wael A. Alanazi, Nader S. AlGhamdi, Musaad A. Alshammari, Mohammed Alswayyed, Ali Alhoshani, Mohammed M. Alanazi, Homood M. As Sobeai, Naif O. Al-Harbi, Abdullah F. Alasmari
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 4, Pp 509-518 (2020)
Saudi Pharmaceutical Journal, Vol 28, Iss 4, Pp 509-518 (2020)
Gefitinib is an effective treatment for patients with locally advanced non-small cell lung cancer. However, it is associated with cardiotoxicity that can limit its clinical use. Liraglutide, a glucagon-like peptide 1 receptor agonist, showed potent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b7230d338302facc1ca135fa14e87e
http://europepmc.org/articles/PMC7132601
http://europepmc.org/articles/PMC7132601
Publikováno v:
Chinese Journal of Lung Cancer, Vol 13, Iss 4, Pp 287-291 (2010)
Background and objective Invasion and metastasis are the primary causes of death in patients with pulmonary carcinoma. The epidermal growth factor (EGF) stimulates A549 cells invasion greatly through activating ERK and PI3K-Akt signaling pathway. The
Externí odkaz:
https://doaj.org/article/eb2a19b6bb1c4db29dc30e6c5b10c7a9
Publikováno v:
The Journal of Biological Chemistry
For most G protein-coupled receptors, the third intracellular loop (IL3) and carboxy-terminal tail (CT) are sites for G protein-coupled receptor kinase (GRK)-mediated phosphorylation, leading to β-arrestin binding and agonist-specific desensitizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76723182b7019939470f5205207a664
http://europepmc.org/articles/PMC7949105
http://europepmc.org/articles/PMC7949105
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101049-(2021)
Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101049-(2021)
Oxidative stress is a key factor contributing to the development of diabetes complications. Glutathione S-transferases (GSTs) protect against products of oxidative stress by conjugating glutathione to electrophilic substrates, producing compounds tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93d59b86a8cf61fe862c908289c6fe9
https://doi.org/10.1016/j.bbrep.2021.101049
https://doi.org/10.1016/j.bbrep.2021.101049
Publikováno v:
Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology
Redox Biology
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma accounting for 5–8% of malignant tumours in children and adolescents. Children with high risk disease have poor prognosis. Anti-RMS therapies include surgery, radiation and combination c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c9157b323344d511e141abe0023e4d
http://www.sciencedirect.com/science/article/pii/S2213231718311406
http://www.sciencedirect.com/science/article/pii/S2213231718311406
Publikováno v:
Paediatrics Publications
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 861-870 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 861-870 (2018)
JACC: Basic to Translational Science
Summary The clinical use of doxorubicin in cancer is limited by cardiotoxic effects that can lead to heart failure. Whereas earlier work focused on the direct impact of doxorubicin on cardiomyocytes, recent studies have turned to the endothelium, bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabc9d341267a231c574509af74d895f
https://ir.lib.uwo.ca/paedpub/2480
https://ir.lib.uwo.ca/paedpub/2480
Autor:
Mikhail I. Shtilman, Oxana V. Klimenko
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 186-192 (2019)
Toxicology Reports, Vol 6, Iss, Pp 186-192 (2019)
Graphical abstract
Highlights • Morphological and genetic changes of colorectal adenocarcinoma cells after treatment with complex of mix piR-30074 and miR-152 and PNVP carrier were obtained. • The combination mix of sncRNAs for the transform
Highlights • Morphological and genetic changes of colorectal adenocarcinoma cells after treatment with complex of mix piR-30074 and miR-152 and PNVP carrier were obtained. • The combination mix of sncRNAs for the transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8847ad90819be1ab52fce449f944c9
https://pubmed.ncbi.nlm.nih.gov/30899675
https://pubmed.ncbi.nlm.nih.gov/30899675
Autor:
Anna L. Means
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Identification and validation of new functionally relevant and pharmacologically actionable targets for pancreatic ductal adenocarcinoma (PDAC) remains a great challenge. Premalignant acinar cell reprogramming (acinar-to-ductal meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74de94d1c1ea932bbea8b4fa1374c44
http://europepmc.org/articles/PMC6889775
http://europepmc.org/articles/PMC6889775
Publikováno v:
Cellular Signalling
Cellular Signalling, 36, 240-254. Elsevier Science
Cellular Signalling, 36, 240-254. Elsevier Science
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart – a response to pathological cues including hypertension and myocardial infarction. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cb407f9f74272b30ad3d70ef8936da
https://lirias.kuleuven.be/handle/123456789/584124
https://lirias.kuleuven.be/handle/123456789/584124
Publikováno v:
Redox Biology
Redox Biology, Vol 1, Iss 1, Pp 319-331 (2013)
Redox Biology, Vol 1, Iss 1, Pp 319-331 (2013)
4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within the vasculature is dependent not only on the rate of lipid peroxidation and HNE synthesis b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88b86f46ba817912a4e88978d67619f
http://europepmc.org/articles/PMC3757694
http://europepmc.org/articles/PMC3757694