Zobrazeno 1 - 10
of 128
pro vyhledávání: '"ERK/AKT"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 5, Pp 804-817 (2023)
Identifying novel targets that control both tumorigenesis and angiogenesis can aid in developing a more potent anti‐angiogenic therapeutic strategy. We previously reported that reduction of FRG1 is associated with increased p38‐MAPK signaling in
Externí odkaz:
https://doaj.org/article/da0f9a2273964097a8d13b6271ad5046
Akademický článek
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Autor:
Yingzi Chang, Lei Alena Dagat, Aisha Yusuf, Yusuf Zahriya, Kotryna Staputyte, Emma Worley, Alex Holt, Natalie Canuteson, Vereena Messieha, Kasey Halila
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 3, Iss , Pp 100094- (2022)
Background: Basic fibroblast growth factor (bFGF)-mediated vascular smooth muscle cell (VSMC) proliferation and migration play an important role in vascular injury-induced neointima formation and subsequent vascular restenosis, a major event that hin
Externí odkaz:
https://doaj.org/article/72b66e9c6c9c40c195314d93eca21229
Autor:
Hongling Yan, Miao Jiang, Fujin Yang, Xueyong Tang, Mao Lin, Chunyan Zhou, Yuzhu Tan, Deming Liu
Publikováno v:
Molecules, Vol 27, Iss 17, p 5469 (2022)
The Src-homology 2 domain-containing phosphatase 2 (SHP2), which is encoded by PTPN11, participates in many cellular signaling pathways and is closely related to various tumorigenesis. Inhibition of the abnormal activity of SHP2 by small molecules is
Externí odkaz:
https://doaj.org/article/5bf07036e3ec473d8c06e2ca248d37e1
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 53, Iss 2 (2020)
The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa cells were di
Externí odkaz:
https://doaj.org/article/c59ed4002e654d16af200b0877aaf965
Autor:
Yang Yu, Chen Chen, Gang Huo, Jinmu Deng, Hongxin Zhao, Rui Xu, Li Jiang, Song Chen, Shali Wang
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Glioma stem cells (GSCs) have been considered to be responsible for treatment failure due to their self-renewal and limitless proliferative property. Recently, the Na+/K+-ATPase a1 (ATP1A1) subunit was described as a novel therapeutic target for glio
Externí odkaz:
https://doaj.org/article/47b28a276b7447d9a03078383a7d316c
Autor:
Hantae Jo, Byungsun Cha, Haneul Kim, Sofia Brito, Byeong Mun Kwak, Sung Tae Kim, Bum-Ho Bin, Mi-Gi Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 656 (2021)
Natural killer (NK) cells are lymphocytes that can directly destroy cancer cells. When NK cells are activated, CD56 and CD107a markers are able to recognize cancer cells and release perforin and granzyme B proteins that induce apoptosis in the target
Externí odkaz:
https://doaj.org/article/c649d0300df64442a164f582e91e94b3
Autor:
Chi Zhang, Songlin Liu, Xianrui Yuan, Zhongliang Hu, Haoyu Li, Ming Wu, Jian Yuan, Zijin Zhao, Jun Su, Xiangyu Wang, Yiwei Liao, Qing Liu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 6, Pp 2173-2185 (2016)
Background: Valproic acid (VPA), an established antiepileptic drug, was assessed for antitumor activity, including its effects on glioblastoma, but its role has not been determined. Methods: In the present study, we investigated VPA-induced apoptosis
Externí odkaz:
https://doaj.org/article/71da6f88b555463692883ab06f4b49ae
Autor:
Guangnan Chen, Tingting Fang, Zhongming Huang, Yiying Qi, Shaohua Du, Tuoyu Di, Zhong Lei, Xiangyu Zhang, Weiqi Yan
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 2, Pp 598-608 (2016)
Background/Aims: MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. Downregulated microRNAs and their roles in cancer development h
Externí odkaz:
https://doaj.org/article/0af9ea9a80e74539b39fea051e0f186c
Akademický článek
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